Skip to Content

Timolol Side Effects

In Summary

More frequently reported side effects include: cardiac failure and weakness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to timolol: oral tablet

As well as its needed effects, timolol may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking timolol, check with your doctor immediately:

More common:
  • Chest pain or discomfort
  • lightheadedness, dizziness, or fainting
  • shortness of breath
  • slow or irregular heartbeat
  • unusual tiredness
Less common:
  • Difficult or labored breathing
  • fast heartbeat
  • tightness in chest
  • wheezing
Rare
  • Noisy breathing
  • small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope
  • swelling of hands, ankles, feet, or lower legs

If any of the following symptoms of overdose occur while taking timolol, get emergency help immediately:

Symptoms of overdose:
  • Blurred vision
  • continuing ringing or buzzing or other unexplained noise in ears
  • headache
  • hearing loss
  • nervousness
  • pounding in the ears
  • sweating

Minor Side Effects

Some timolol side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Itching skin
  • red, sore eyes
Rare
  • Acid or sour stomach
  • belching
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • decreased interest in sexual intercourse
  • feeling of constant movement of self or surroundings
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • nausea
  • sensation of spinning
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to timolol: compounding powder, oral tablet

Cardiovascular

Common (1% to 10%): Bradycardia, arrhythmia, cardiac failure, hypotension, claudication, Raynaud's phenomenon, cold and cyanotic extremities, paranesthesia of the extremities, atrioventricular conduction disturbances
Uncommon (0.1% to 1%): Chest pain, syncope, edema, second or third degree AV block, sinoatrial block, palpitations
Frequency not reported: Cardiac arrest, cerebral vascular accident, worsening of angina pectoris, worsening of arterial insufficiency, vasodilatation[Ref]

Respiratory

Common (1% to 10%): Dyspnea, pulmonary edema, bronchial obstruction
Uncommon (0.1% to 1%): Bronchial spasm (especially in patients with bronchial asthma), rales
Frequency not reported: Cough[Ref]

Dermatologic

Common (1% to 10%): Pruritus
Uncommon (0.1% to 1%): Rash
Rare (less than 0.1%): Generalized psoriasis, hyperpigmented nailbeds
Frequency not reported: Skin irritation, increased skin pigmentation, alopecia, hyperhidrosis, worsening of psoriasis, erythematous rashes[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, digestive disorders, constipation, diarrhea, abdominal discomfort
Uncommon (0.1% to 1%): Dyspepsia
Frequency not reported: GI pain, vomiting[Ref]

Genitourinary

Frequency not reported: Urinary retention, impotence, decreased libido[Ref]

Hypersensitivity

Frequency not reported: Anaphylaxis[Ref]

Musculoskeletal

Frequency not reported: Arthralgia[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Vertigo, paresthesia
Frequency not reported: Local weakness, myasthenia gravis like symptoms[Ref]

Psychiatric

Very common (10% or more): Insomnia (10%)
Common (1% to 10%): Nightmares
Uncommon (0.1% to 1%): Hallucinations
Frequency not reported: Depression, somnolence, nervousness, diminished concentration, psychoses, confusion, sleep disturbances[Ref]

Hematologic

Frequency not reported: Nonthrombocytopenic purpura[Ref]

Hepatic

Frequency not reported: Hepatomegaly[Ref]

Metabolic

Frequency not reported: Weight loss, hyperglycemia, hypoglycemia, increased serum triglycerides, increased LDL cholesterol, increased VLDL cholesterol, decreased HDL cholesterol[Ref]

Ocular

Common (1% to 10%): Eye irritation
Frequency not reported: Visual disturbances, diplopia, ptosis, dry eyes, impaired vision[Ref]

Other

Common (1% to 10%): Fatigue/tiredness, asthenia
Uncommon (0.1% to 1%): Tinnitus
Frequency not reported: Pain in extremity, decreased exercise tolerance, fever[Ref]

Renal

Frequency not reported: Retroperitoneal fibrosis[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Timolol Maleate (timolol)." Mylan Pharmaceuticals Inc, Morgantown, WV.

It is possible that some side effects of timolol may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide