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Timentin Side Effects

Generic Name: clavulanate / ticarcillin

Note: This page contains side effects data for the generic drug clavulanate / ticarcillin. It is possible that some of the dosage forms included below may not apply to the brand name Timentin.

For the Consumer

Applies to clavulanate / ticarcillin: intravenous powder for solution, intravenous solution

As well as its needed effects, clavulanate / ticarcillin may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking clavulanate / ticarcillin, check with your doctor or nurse immediately:

  • Blood in the urine
  • frequent urination
  • lower abdominal or stomach cramping
  • painful urination
Incidence not known:
  • Abdominal or stomach cramps, pain, or tenderness
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating
  • changes in skin color
  • chest pain or discomfort
  • chills
  • clay-colored stools
  • convulsions
  • cough
  • dark urine
  • diarrhea
  • diarrhea, watery and severe, which may also be bloody
  • dizziness
  • fast heartbeat
  • fever
  • general tiredness and weakness
  • headache
  • increased thirst
  • irritability
  • itching
  • joint or muscle pain
  • loss of appetite
  • lower back or side pain
  • muscle twitching
  • nausea or vomiting
  • pain, tenderness, or swelling of the foot or leg
  • pinpoint red spots on the skin
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • restlessness
  • seizures
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling or inflammation of the mouth
  • swollen glands
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight loss
  • upper right abdominal or stomach pain
  • vomiting of blood
  • yellow eyes or skin

Severity: Minor

Some clavulanate / ticarcillin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • change in taste or bad unusual or unpleasant (after) taste
  • difficulty with moving
  • excess air or gas in the stomach or intestines
  • full feeling
  • heartburn
  • muscle aching, cramping, or stiffness
  • passing gas
  • swollen joints

For Healthcare Professionals

Applies to clavulanate / ticarcillin: intravenous powder for injection, intravenous solution


Pseudomembranous colitis has been reported in patients treated with penicillins, and may occur during or after treatment. If diarrhea occurs and is unresponsive to discontinuation of the drug and/or standard therapy, pseudomembranous colitis should be considered.[Ref]

Common (1% to 10%): Nausea (greater than or equal to 1%), diarrhea (greater than or equal to 1%)
Frequency not reported: Clostridium difficile associated diarrhea
Postmarketing reports: Taste and smell disturbances, stomatitis, flatulence, nausea, vomiting, diarrhea, epigastric pain, pseudomembranous colitis[Ref]


Common (1% to 10%): Rash (greater than or equal to 1%)
Postmarketing reports: Skin rash, pruritus, urticaria, bullous reactions (including erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome)[Ref]


Common (1% to 10%): Elevated eosinophils (greater than or equal to 3%)
Postmarketing reports: Thrombocytopenia, leukopenia, neutropenia, eosinophilia, decreased hemoglobin or hematocrit, prolonged prothrombin time and bleeding time[Ref]

The risk of significant bleeding may be increased in patients over the age of 60 years, patients receiving cytotoxic chemotherapy, patients with preexisting thrombocytopenia, and azotemia, and patients undergoing surgical procedures.

Leukopenia has been reported in 23% of patients with liver disease receiving beta-lactam antibiotics.[Ref]


Common (1% to 10%): Elevated AST (greater than or equal to 3%), elevated ALT (greater than or equal to 3%)
Postmarketing reports: Elevated AST, elevated ALT, elevated serum alkaline phosphatase, elevated serum LDH, elevated serum bilirubin, transient hepatitis, cholestatic jaundice[Ref]


Postmarketing reports: Hypersensitivity reactions (including skin rash, pruritus, urticaria, arthralgia, myalgia, drug fever, chills, chest discomfort, anaphylactic reactions, bullous reactions [including erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome])[Ref]


Frequency not reported: Hypokalemia
Postmarketing reports: Hypernatremia, decreased serum potassium, decreased uric acid[Ref]

Some studies have shown a correlation between the degree of hypokalemia and the dose of ticarcillin in addition to the serum BUN/creatinine ratio. These findings suggest that dehydration and high doses may be risk factors for hypokalemia.[Ref]


Common (1% to 10%): Phlebitis at the injection site (greater than or equal to 1%)
Postmarketing reports: Pain at the injection site, burning at the injection site, swelling at the injection site, induration at the injection site, thrombophlebitis with intravenous administration[Ref]

Nervous system

Postmarketing reports: Headache, giddiness, neuromuscular hyperirritability, convulsive seizures[Ref]


An increased incidence of vaginal yeast infections has been associated with penicillins.[Ref]

Frequency not reported: Vaginal yeast infections
Postmarketing reports: Hemorrhagic cystitis[Ref]


Postmarketing reports: Elevated serum creatinine and/or BUN[Ref]


Postmarketing reports: Arthralgia, myalgia


Postmarketing reports: Drug fever, chills, chest discomfort


1. Schwigon CD, Hulla FW, Schulza B, Maslak A "Timentin in the treatment of nosocomial bronchopulmonary infections in intensive care units." J Antimicrob Chemother 17 (1986): 115-22

2. Gentry LO, Macko V, Lind R, Heilman A "Ticarcillin plus clavulanic acid (timentin) therapy for osteomyelitis." Am J Med 79 (1985): 116-21

3. Link AS, Jr "Efficacy and safety of ticarcillin plus clavulanic acid and piperacillin in patients with lower respiratory tract infections." Am J Med 79 (1985): 86-7

4. Ryan J, Dudley FJ "Cholestasis with ticarcillin-potassium clavulanate (timentin)." Med J Aust 156 (1992): 291

5. Sanders CV, Marier RL, Aldridge KE, Derks FW, Martin DH "Safety and effectiveness of ticarcillin plus clavulanic acid in the treatment of community-acquired acute pyelonephritis in adult women." Am J Med 79 (1985): 96-100

6. Croydon EA, Hermoso C "An evaluation of the safety and tolerance to timentin." J Antimicrob Chemother 17 (1986): 233-40

7. "Product Information. Timentin (ticarcillin-clavulanate)." SmithKline Beecham, Philadelphia, PA.

8. Tehan S, Horobin J, Gordonsmith R, McLatchie GR "Ticarcillin plus clavulanic acid (timentin): further UK trial results." Br J Clin Pract 42 (1988): 8-16

9. Sweet JM, Jones MP "Intrahepatic cholestasis due to ticarcillin-clavulanate." Am J Gastroenterol 90 (1995): 675-6

10. Westenfelder M, Pelz K, Hulla FW "Clinical evaluation of timentin in complicated urinary tract infections." J Antimicrob Chemother 17 (1986): 97-102

11. Shenep JL, Hughes WT, Roberson PK, et al "Vancomycin, ticarcillin, and amikacin compared with ticarcillin-clavulanate and amikacin in the empirical treatment of febrile, neutropenic children with cancer." N Engl J Med 319 (1988): 1053-8

12. Meylan PR, Calandra T, Casey PA, Glauser MP "Clinical experience with timentin in severe hospital infections." J Antimicrob Chemother 17 (1986): 127-39

13. Ramakrishnan K, Scheid DC "Diagnosis and management of acute pyelonephritis in adults." Am Fam Physician 71 (2005): 933-42

14. Fass RJ, Copelan EA, Brandt JT, Moeschberger ML, Ashton JJ "Platelet-mediated bleeding caused by broad-spectrum penicillins." J Infect Dis 155 (1987): 1242-8

15. Mostow SR, O'Brien RF "Safety and effectiveness of ticarcillin plus clavulanate potassium in treatment of lower respiratory tract infections." Am J Med 79 (1985): 78-80

16. Stuart JJ "Ticarcillin-induced hemorrhage in a patient with thrombocytosis." South Med J 73 (1980): 1084-5

17. Gastineau D, Spector R, Philips D "Severe neutropenia associated with ticarcillin therapy." Ann Intern Med 94 (1981): 711-2

18. Brown LA, Goldberg ND, Shearer WT "Long-term ticarcillin desensitization by the continuous oral administration of penicillin." J Allergy Clin Immunol 69 (1982): 51-4

19. Ramirez-Ronda CH, Gutierrez J, Bermudez RH "Comparative effectiveness, safety and tolerance of mezlocillin and ticarcillin: a prospective randomized trial." J Antimicrob Chemother 9 (1982): 125-9

20. Finch RA "Hypernatremia during lithium and ticarcillin therapy." South Med J 74 (1981): 376-7

21. Welter J, Wittman DH, Freitag V "Ticarcillin therapy of risk patients with infections due to pseudomonas aeruginosa." J Int Med Res 9 (1981): 44-51

22. Nanji AA, Lindsay J "Ticarcillin associated hypokalemia." Clin Biochem 15 (1982): 118-9

It is possible that some side effects of Timentin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.