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Synthetic Conjugated Estrogens A Side Effects

Generic Name: conjugated estrogens topical

Note: This document contains side effect information about conjugated estrogens topical. Some of the dosage forms listed on this page may not apply to the brand name Synthetic Conjugated Estrogens A.

For the Consumer

Applies to conjugated estrogens topical: vaginal cream

Along with its needed effects, conjugated estrogens topical (the active ingredient contained in Synthetic Conjugated Estrogens A) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking conjugated estrogens topical:

More Common

  • Breast pain
  • change in vaginal discharge
  • cough or hoarseness
  • fever or chills
  • increased clear or white vaginal discharge
  • itching of the vagina or genital area
  • lower back or side pain
  • pain during sexual intercourse
  • pain or feeling of pressure in the pelvis
  • painful or difficult urination
  • thick, white vaginal discharge with no odor or with a mild odor
  • vaginal bleeding

Less Common

  • Feeling faint, dizzy, or lightheaded
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • headache
  • sweating

Incidence Not Known

  • Abdominal or stomach bloating
  • abnormal uterine bleeding or spotting
  • acne
  • anxiety
  • bloody or cloudy urine
  • breast tenderness, enlargement, pain, or discharge
  • chest pain or discomfort
  • decreased vision or other changes in vision
  • difficulty with swallowing
  • enlargement of the penis or testes
  • fast heartbeat
  • frequent urge to urinate
  • growth of pubic hair
  • hives
  • itching
  • itching of the vagina or outside genitals
  • nausea
  • pain during sexual intercourse
  • pain or discomfort in the arms, jaw, back, or neck
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid increase in height
  • shortness of breath
  • stomach pain
  • sudden shortness of breath or troubled breathing
  • sweating
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting
  • wheezing

Some side effects of conjugated estrogens topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

  • Body aches or pain
  • congestion
  • increased dryness or soreness of the throat
  • runny nose
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes

Incidence Not Known

  • Abdominal or stomach cramps
  • changes in weight
  • decreased or increased interest in sexual intercourse
  • depression
  • difficulty with moving
  • headache, severe and throbbing
  • heavy bleeding
  • inability to have or keep an erection
  • increased hair growth, especially on the face
  • irritability
  • itching of the vagina or genitals
  • leg cramps
  • loss of scalp hair
  • loss or increase in sexual ability, desire, drive, or performance
  • mood changes
  • muscle pain or stiffness
  • nervousness
  • pain
  • pain in the joints
  • patchy brown or dark brown discoloration of the skin
  • poor insight and judgment
  • problems with memory or speech
  • swelling of the breasts or breast soreness in both females and males
  • trouble recognizing objects
  • trouble thinking and planning
  • weakness

For Healthcare Professionals

Applies to conjugated estrogens topical: vaginal cream with applicator


Common (1% to 10%): Breast pain, leukorrhea, dysuria, vaginal hemorrhage, vaginal moniliasis, vaginitis, vulvovaginal disorder

Uncommon (0.1% to 1%): Breast enlargement, urinary urgency

Postmarketing reports: Abnormal uterine bleeding or spotting, dysmenorrhea or pelvic pain, increase in size of uterine leiomyomata, change in cervical secretion, cystitis-like syndrome, application site reactions of vulvovaginal discomfort (including burning, irritation, and genital pruritus), endometrial hyperplasia, endometrial cancer, precocious puberty, breast tenderness, breast discharge, fibrocystic breast changes, breast cancer, gynecomastia in males[Ref]


Common (1% to 10%): Vasodilation

Postmarketing reports: Deep vein thrombosis, myocardial infarction, increase in blood pressure[Ref]

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Dizziness

Postmarketing reports: Stroke, migraine, dementia[Ref]


Postmarketing reports: Nausea, vomiting, abdominal cramps, bloating[Ref]


Common (1% to 10%): Acne, pruritus

Postmarketing reports: Chloasma that may persist when drug is discontinued, loss of scalp hair, hirsutism, rash[Ref]


Common (1% to 10%): Moniliasis, pain

Postmarketing reports: Increase or decrease in weight, edema[Ref]


Postmarketing reports: Mental depression, mood disturbances, nervousness, irritability, changes in libido[Ref]


Postmarketing reports: Pulmonary embolism, exacerbation of asthma[Ref]


Common (1% to 10%): Muscle cramp

Postmarketing reports: Arthralgias, leg cramps[Ref]


Postmarketing reports: Hypersensitivity[Ref]


Postmarketing reports: Increased incidence of gallbladder disease[Ref]


Postmarketing reports: Glucose intolerance, increased triglycerides[Ref]


Postmarketing reports: Retinal vascular thrombosis, intolerance to contact lenses[Ref]


1. "Product Information. Premarin Vaginal (conjugated estrogens topical)." Wyeth Laboratories, Philadelphia, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about Synthetic Conjugated Estrogens A (conjugated estrogens topical)

Consumer resources

Other brands: Premarin Vaginal

Professional resources

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