Skip to Content

Synthetic Conjugated Estrogens A Side Effects

Generic Name: conjugated estrogens topical

Note: This page contains side effects data for the generic drug conjugated estrogens topical. It is possible that some of the dosage forms included below may not apply to the brand name Synthetic Conjugated Estrogens A.

For the Consumer

Applies to conjugated estrogens topical: vaginal cream

As well as its needed effects, conjugated estrogens topical (the active ingredient contained in Synthetic Conjugated Estrogens A) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking conjugated estrogens topical, check with your doctor immediately:

More common:
  • Breast pain
  • change in vaginal discharge
  • cough or hoarseness
  • fever or chills
  • increased clear or white vaginal discharge
  • itching of the vagina or genital area
  • lower back or side pain
  • pain during sexual intercourse
  • pain or feeling of pressure in the pelvis
  • painful or difficult urination
  • thick, white vaginal discharge with no odor or with a mild odor
  • vaginal bleeding
Less common:
  • Feeling faint, dizzy, or lightheaded
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • headache
  • sweating
Incidence not known:
  • Abdominal or stomach bloating
  • abnormal uterine bleeding or spotting
  • acne
  • anxiety
  • bloody or cloudy urine
  • breast tenderness, enlargement, pain, or discharge
  • chest pain or discomfort
  • decreased vision or other changes in vision
  • difficulty with swallowing
  • enlargement of the penis or testes
  • fast heartbeat
  • frequent urge to urinate
  • growth of pubic hair
  • hives
  • itching
  • itching of the vagina or outside genitals
  • nausea
  • pain during sexual intercourse
  • pain or discomfort in the arms, jaw, back, or neck
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid increase in height
  • shortness of breath
  • stomach pain
  • sudden shortness of breath or troubled breathing
  • sweating
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting
  • wheezing

Minor Side Effects

Some conjugated estrogens topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Abdominal or stomach pain
  • back pain
  • diarrhea
  • headache
  • lack or loss of strength
Less common:
  • Body aches or pain
  • congestion
  • increased dryness or soreness of the throat
  • runny nose
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes
Incidence not known:
  • Abdominal or stomach cramps
  • changes in weight
  • decreased or increased interest in sexual intercourse
  • depression
  • difficulty with moving
  • headache, severe and throbbing
  • heavy bleeding
  • inability to have or keep an erection
  • increased hair growth, especially on the face
  • irritability
  • itching of the vagina or genitals
  • leg cramps
  • loss of scalp hair
  • loss or increase in sexual ability, desire, drive, or performance
  • mood changes
  • muscle pain or stiffness
  • nervousness
  • pain
  • pain in the joints
  • patchy brown or dark brown discoloration of the skin
  • poor insight and judgment
  • problems with memory or speech
  • swelling of the breasts or breast soreness in both females and males
  • trouble recognizing objects
  • trouble thinking and planning
  • weakness

For Healthcare Professionals

Applies to conjugated estrogens topical: vaginal cream with applicator


Common (1% to 10%): Breast pain, leukorrhea, dysuria, vaginal hemorrhage, vaginal moniliasis, vaginitis, vulvovaginal disorder
Uncommon (0.1% to 1%): Breast enlargement, urinary urgency
Postmarketing reports: Abnormal uterine bleeding or spotting, dysmenorrhea or pelvic pain, increase in size of uterine leiomyomata, change in cervical secretion, cystitis-like syndrome, application site reactions of vulvovaginal discomfort (including burning, irritation, and genital pruritus), endometrial hyperplasia, endometrial cancer, precocious puberty, breast tenderness, breast discharge, fibrocystic breast changes, breast cancer, gynecomastia in males[Ref]


Common (1% to 10%): Vasodilation
Postmarketing reports: Deep vein thrombosis, myocardial infarction, increase in blood pressure[Ref]

Nervous system

Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Dizziness
Postmarketing reports: Stroke, migraine, dementia[Ref]


Postmarketing reports: Nausea, vomiting, abdominal cramps, bloating[Ref]


Common (1% to 10%): Acne, pruritus
Postmarketing reports: Chloasma that may persist when drug is discontinued, loss of scalp hair, hirsutism, rash[Ref]


Common (1% to 10%): Moniliasis, pain
Postmarketing reports: Increase or decrease in weight, edema[Ref]


Postmarketing reports: Mental depression, mood disturbances, nervousness, irritability, changes in libido[Ref]


Postmarketing reports: Pulmonary embolism, exacerbation of asthma[Ref]


Common (1% to 10%): Muscle cramp
Postmarketing reports: Arthralgias, leg cramps[Ref]


Postmarketing reports: Hypersensitivity[Ref]


Postmarketing reports: Increased incidence of gallbladder disease[Ref]


Postmarketing reports: Glucose intolerance, increased triglycerides[Ref]


Postmarketing reports: Retinal vascular thrombosis, intolerance to contact lenses[Ref]


1. "Product Information. Premarin Vaginal (conjugated estrogens topical)." Wyeth Laboratories, Philadelphia, PA.

It is possible that some side effects of Synthetic Conjugated Estrogens A may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

More about Synthetic Conjugated Estrogens A (conjugated estrogens topical)

Consumer resources

Other brands: Premarin Vaginal

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.