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Supartz Side Effects

Generic name: sodium hyaluronate

Medically reviewed by Last updated on Jan 20, 2023.

Note: This document contains side effect information about sodium hyaluronate. Some dosage forms listed on this page may not apply to the brand name Supartz.

Applies to sodium hyaluronate: injection gel/jelly, injection solution.

Serious side effects of Supartz

Along with its needed effects, sodium hyaluronate (the active ingredient contained in Supartz) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium hyaluronate:

Less common

  • Blue color or flushing or redness of skin
  • cough
  • difficulty in swallowing
  • dizziness or feeling faint (severe)
  • fever
  • redness or pain at place of injection
  • skin rash, hives, and/or itching
  • stuffy nose
  • swelling of eyelids, face, or lips
  • tightness in chest, troubled breathing, and/or wheezing

Other side effects of Supartz

Some side effects of sodium hyaluronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • headache
  • itching of the skin
  • large, nonelevated blue or purplish patches in the skin
  • loss of appetite
  • nausea and/or vomiting
  • stomach pain
  • swelling of the knee

For Healthcare Professionals

Applies to sodium hyaluronate: intra-articular solution.


Common (1% to 10%): Injection site pain/swelling/effusion/redness/warmth

Uncommon (0.1% to 1%):[Ref]


Frequency not reported: Hayfever reaction on face and neck, reaction on forearms and knees

Postmarketing reports: Anaphylaxis/anaphylactoid reaction[Ref]


Frequency not reported: Swelling of the face/eyelids/mouth/extremities, fever[Ref]


Common (1% to 10%): Nausea, vomiting, abdominal pain, diarrhea, dyspepsia[Ref]


Frequency not reported: Transient hypotension[Ref]


Very common (10% or more): Arthralgia (18%), arthropathy/arthrosis/arthritis (11%)

Common (1% to 10%): Back pain, leg discomfort, leg pain[Ref]


Common (1% to 10%): Influenza-like reaction[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Upper respiratory tract infection, sinusitis, bronchitis, rhinitis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness[Ref]


Frequency not reported: Rash, itching[Ref]


1. "Product Information. Hyalgan (sodium hyaluronate)." Sanofi Winthrop Pharmaceuticals

2. "Product Information. Supartz (sodium hyaluronate)." Smith and Nephew Wound Management Division (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.