Sugammadex Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 24, 2024.

Applies to sugammadex: intravenous solution.

Precautions

It is important that your doctor check your progress closely while you or your child are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control, including condoms and spermicides along with your pills. Use an effective form of birth control for at least 7 days after receiving sugammadex.

This medicine may cause serious allergic reactions including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Bradycardia may occur after receiving this medicine. Tell your doctor right away if you have chest pain or discomfort, lightheadedness, dizziness or fainting, slow or irregular heartbeat, trouble breathing, or unusual tiredness.

This medicine may increase your risk of bleeding problems. Tell your doctor right away if you have sudden or severe headache, problems with vision, speech, or walking, or unusual bleeding or bruising.

Before you have any medical tests, tell the medical doctor in charge that you were given this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of sugammadex

Along with its needed effects, sugammadex may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sugammadex:

Other side effects of sugammadex

Some side effects of sugammadex may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to sugammadex: intravenous solution.

General adverse events

The most commonly reported adverse reactions have included vomiting, pain, nausea, hypotension and headache.^[Ref]

Cardiovascular

• Common (1% to 10%): Abnormal ECG, hypertension, hypotension, tachycardia, bradycardia, abnormal or prolonged QT interval
• Postmarketing reports: Bradycardia with cardiac arrest, atrial fibrillation, atrioventricular block, cardiac/cardiorespiratory arrest, ST segment changes, supraventricular tachycardia/extrasystoles, tachycardia, ventricular fibrillation, and ventricular tachycardia^[Ref]

Cases of marked bradycardia, some resulting in cardiac arrest, have occurred within minutes of administering this drug. Cardiac electrophysiology studies have shown that at 2 times the maximum recommended dose, the QT interval was not prolonged to any clinically relevant extent.^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Anaphylaxis, hypersensitivity reactions
• Postmarketing reports: Anaphylactic shock, anaphylactic reaction, anaphylactoid reaction, Type I hypersensitivity^[Ref]

In a dedicated hypersensitivity study in healthy volunteers, anaphylaxis occurred in 1 of 299 patients (0.3%). This patient experienced anaphylaxis with the first dose (16 mg/kg) and symptoms included conjunctival edema, urticaria, erythema, swelling of the uvula, and reduction in peak expiratory flow. Hypersensitivity reactions including nausea, pruritus, and urticaria occurred in a dose-related manner with more reactions occurring in the 16 mg/kg dose group compared to the 4 mg/kg group.

Anaphylaxis has been reported at all doses. The most commonly described reactions included in reports of anaphylaxis have included dermatologic reactions (e.g., urticaria, rash, erythema, flushing, and skin eruption), and clinically important hypotension often requiring vasopressors for circulatory support. There have also been reports of prolonged hospitalization with the use of additional respiratory support in some patients.^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea (up to 26%), vomiting (up to 15%)
• Uncommon (0.1% to 1%): Abdominal pain, flatulence, dry mouth^[Ref]

Respiratory

• Common (1% to 10%): Airway complication of anesthesia, oropharyngeal pain, cough
• Frequency not reported: Bronchospasm
• Postmarketing reports: Laryngospasm, dyspnea, wheezing, pulmonary edema, respiratory arrest^[Ref]

Bronchospasm was observed in patients with a history of pulmonary complications.^[Ref]

Dermatologic

• Common (1% to 10%): Pruritus, erythema^[Ref]

Hematologic

• Common (1% to 10%): Decreased red blood cell count, hematoma, anemia^[Ref]

Local

• Common (1% to 10%): Injection site pain^[Ref]

Metabolic

• Common (1% to 10%): Hypocalcemia^[Ref]

Musculoskeletal

• Common (1% to 10%): Extremity pain, musculoskeletal pain, myalgia, creatine phosphokinase increased^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness, hypoesthesia, dysgeusia^[Ref]

Other

• Very common (10% or more): Pain (up to 52%)
• Common (1% to 10%): Procedural complication, anesthetic complication, wound hemorrhage, pyrexia, chills, ear and labyrinth disorders
• Uncommon (0.1% to 1%): Recurrence of neuromuscular blockade^[Ref]

In clinical studies using this drug at doses labeled for the depth of neuromuscular blockade (n=2022), less than 1% of patients were observed to have recurrence of neuromuscular blockade as based on neuromuscular monitoring or clinical evidence.

Airway complications of anesthesia have included bucking against the endotracheal tube, coughing, mild bucking, arousal reaction during surgery, coughing during the anesthetic procedure or during surgery, or anesthetic procedure related spontaneous breath of patient. Anesthetic complications include reports of the restoration of neuromuscular function (e.g., movement of limb or body, grimacing, or suckling on the endotracheal tube). Procedural complications include coughing, tachycardia, bradycardia, movement, and increased heart rate.^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia, anxiety, restlessness, depression, sleep disorder^[Ref]

See also:

Further information

Sugammadex side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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