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Sugammadex Dosage

Medically reviewed by Last updated on May 17, 2024.

Applies to the following strengths: 100 mg/mL

Usual Adult Dose for Reversal of Nondepolarizing Muscle Relaxants

Routine reversal (rocuronium or vecuronium):
4 mg/kg IV once if recovery has reached at least 1 to 2 posttetanic counts (PTC) and no twitch responses to train-of-four (TOF) stimulation
2 mg/kg IV once if recovery has reached reappearance of second twitch response to TOF stimulation

Immediate reversal (rocuronium only):
16 mg/kg IV once


Uses: For the reversal of different levels of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery.

Renal Dose Adjustments

Severe renal impairment: Use not recommended

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

The use of lower than recommended doses of sugammadex may increase the risk of neuromuscular blockade recurrence after initial reversal.

Minimum Wait Times for Re-Administration of Rocuronium or Vecuronium after Reversal with up to 4 mg/kg of Sugammadex:

*When rocuronium 1.2 mg/kg is given within 30 minutes after reversal with sugammadex, the onset of neuromuscular blockade may be delayed up to approximately 4 minutes and the duration of neuromuscular blockade may be shortened up to approximately 15 minutes

Minimum wait time for re-administration of rocuronium after sugammadex 16 mg/kg reversal is 24-hours.

If neuromuscular blockade is required before the recommended wait time has elapsed:


Safety and efficacy have not been established in patients younger than 17 years.

Consult WARNINGS section for additional precautions.


Not recommended

Other Comments

Administration advice:

Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:



Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.