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Sodium Edecrin Side Effects

Generic Name: ethacrynic acid

Note: This page contains side effects data for the generic drug ethacrynic acid. It is possible that some of the dosage forms included below may not apply to the brand name Sodium Edecrin.

For the Consumer

Applies to ethacrynic acid: oral tablet

As well as its needed effects, ethacrynic acid (the active ingredient contained in Sodium Edecrin) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking ethacrynic acid, check with your doctor immediately:

  • Bleeding gums
  • bloating
  • clay-colored stools
  • constipation
  • darkened urine
  • indigestion
  • itching
  • large, flat, blue or purplish patches in the skin
  • loss of appetite
  • nausea
  • painful knees and ankles
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • pinpoint red spots on skin
  • raised red swellings on the skin, the buttocks, legs, or ankles
  • skin rash
  • unpleasant breath odor
  • vomiting of blood
  • yellow eyes or skin
Incidence not determined
  • Anxiety
  • black, tarry stools
  • blood in urine
  • blurred vision
  • cold sweats
  • coma
  • confusion
  • convulsions (seizures)
  • cool, pale skin
  • cough or hoarseness
  • depression
  • dizziness
  • dry mouth
  • fast heartbeat
  • fever with or without chills
  • flushed, dry skin
  • fruit-like breath odor
  • general feeling of tiredness or weakness
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • joint pain, stiffness, or swelling
  • lower back, side, or stomach pain
  • nausea
  • nervousness
  • nightmares
  • painful or difficult urination
  • pale skin
  • shakiness
  • shortness of breath
  • slurred speech
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sweating
  • swelling of the feet or lower legs
  • troubled breathing
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • watery and severe diarrhea

If any of the following symptoms of overdose occur while taking ethacrynic acid, get emergency help immediately:

Symptoms of overdose:
  • Confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • increase in heart rate
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • rapid breathing
  • sunken eyes
  • thirst
  • trembling
  • weakness and heaviness of the legs
  • wrinkled skin

Minor Side Effects

Some ethacrynic acid side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not determined
  • Continuing ringing or buzzing or other unexplained noise in ears
  • difficulty swallowing
  • fear
  • feeling of constant movement of self or surroundings
  • feeling of fullness in the ears
  • general feeling of discomfort or illness
  • hearing loss
  • mild diarrhea
  • sensation of spinning
  • stomach soreness or discomfort
  • weight loss

For Healthcare Professionals

Applies to ethacrynic acid: intravenous powder for injection, oral tablet


Frequency not reported: Anorexia, reversible hyperuricemia, hyperglycemia, acute gout, acute symptomatic hypoglycemia with convulsions, blood glucose increased, glucose tolerance test altered[Ref]


Frequency not reported: Abdominal discomfort or pain, dysphagia, nausea, vomiting, diarrhea, watery profuse diarrhea, gastrointestinal bleeding, acute pancreatitis[Ref]

Nervous system

Frequency not reported: Deafness, tinnitus, vertigo with fullness in the ears, headache[Ref]


Frequency not reported: Malaise, fatigue, fever, chills[Ref]


Frequency not reported: Agranulocytosis, severe neutropenia, thrombocytopenia[Ref]


Frequency not reported: Henoch Schonlein purpura, rash[Ref]


Frequency not reported: Urinary urate excretion decreased, hematuria[Ref]


Frequency not reported: Jaundice, abnormal liver function tests[Ref]


Frequency not reported: Apprehension, confusion[Ref]


Frequency not reported: Local irritation, local pain[Ref]


Frequency not reported: Blurred vision[Ref]


1. "Product Information. Edecrin (ethacrynic acid)." Merck & Co, Inc, West Point, PA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of Sodium Edecrin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.