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Sodium biphosphate / sodium phosphate Side Effects

Medically reviewed by Last updated on Jun 20, 2024.

Applies to sodium biphosphate / sodium phosphate: oral solution, oral tablet. Other dosage forms:


Oral route (Tablet)

Acute phosphate nephropathy has been reported in association with the use of oral sodium phosphate products, some cases resulting in permanent impairment of renal function, including cases requiring long-term dialysis. Risk factors for developing acute phosphate nephropathy include increased age, hypovolemia, renal impairment, bowel obstruction, or active colitis. Use of medications that may impair renal perfusion or function may also increase risk. These include diuretics, ACE inhibitors, angiotensin receptor blockers (ARBs), and possibly NSAIDs. However, cases have occurred in patients with no identifiable risk factors. OsmoPrep®: Advise patients of the importance of following the recommended split dosage regimen and the importance of adequate hydration before, during and after the use of sodium phosphate, dibasic and sodium phosphate, monobasic. Avoid additional sodium phosphate-based purgative or enema products. Visicol®: It is important to use the dose and dosing regimen as recommended (pm/am split dose)..

Serious side effects

Along with its needed effects, sodium biphosphate / sodium phosphate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium biphosphate / sodium phosphate:

More common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking sodium biphosphate / sodium phosphate:

Symptoms of overdose

For Healthcare Professionals

Applies to sodium biphosphate / sodium phosphate: oral solution, oral tablet, rectal enema.


The most common adverse events were abdominal bloating, nausea, abdominal pain, and vomiting.[Ref]


Very common (10% or more): Bloating (39%), nausea (37%), abdominal pain (24%), vomiting (10%)[Ref]


Postmarketing reports: Renal impairment, increased blood urea nitrogen (BUN), increased creatinine, acute renal failure, acute phosphate nephropathy, nephrocalcinosis, renal tubular necrosis[Ref]

Nervous system

Postmarketing reports: Seizures[Ref]


Postmarketing reports: Arrhythmias[Ref]


Postmarketing reports: Hypersensitivity reactions (including anaphylaxis, rash, pruritus, urticaria, throat tightness, bronchospasm, dyspnea, pharyngeal edema, dysphagia, paresthesia, swelling of the lips and tongue, and facial swelling)[Ref]


1. (2018) "Product Information. OsmoPrep (sodium acid phophate-sodium phosphate)." Valeant Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.