Sodium Biphosphate / Sodium Phosphate Side Effects
Medically reviewed by Drugs.com. Last updated on Jan 21, 2025.
Applies to sodium biphosphate / sodium phosphate: rectal enema.
Other dosage forms:
Serious side effects
Along with its needed effects, sodium biphosphate / sodium phosphate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking sodium biphosphate / sodium phosphate:
Incidence not known
- bleeding in the rectum
- confusion
- decreased urination
- dizziness
- dry mouth
- fainting
- increase in heart rate
- lightheadedness
- rapid breathing
- sunken eyes
- thirst
- unusual tiredness or weakness
- wrinkled skin
For healthcare professionals
Applies to sodium biphosphate / sodium phosphate: oral solution, oral tablet, rectal enema.
General adverse events
The most common adverse events were abdominal bloating, nausea, abdominal pain, and vomiting.[Ref]
Gastrointestinal
- Very common (10% or more): Bloating (39%), nausea (37%), abdominal pain (24%), vomiting (10%)[Ref]
Renal
- Postmarketing reports: Renal impairment, increased blood urea nitrogen (BUN), increased creatinine, acute renal failure, acute phosphate nephropathy, nephrocalcinosis, renal tubular necrosis[Ref]
Nervous system
- Postmarketing reports: Seizures[Ref]
Cardiovascular
- Postmarketing reports: Arrhythmias[Ref]
Hypersensitivity
- Postmarketing reports: Hypersensitivity reactions (including anaphylaxis, rash, pruritus, urticaria, throat tightness, bronchospasm, dyspnea, pharyngeal edema, dysphagia, paresthesia, swelling of the lips and tongue, and facial swelling)[Ref]
References
1. (2018) "Product Information. OsmoPrep (sodium acid phosphate-sodium phosphate)." Valeant Pharmaceuticals
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- Drug class: laxatives
Patient resources
- Sodium biphosphate and sodium phosphate drug information
- Sodium biphosphate and sodium phosphate rectal
- Sodium phosphate dibasic and sodium phosphate monobasic (Intravenous) (Advanced Reading)
- Sodium phosphate dibasic and sodium phosphate monobasic (Oral) (Advanced Reading)
- Sodium phosphate dibasic and sodium phosphate monobasic (Rectal) (Advanced Reading)
Other brands
Fleet Enema, Fleet Phospho Soda, Disposable Enema, OsmoPrep, Visicol
Professional resources
- Monobasic Sodium Phosphate and Dibasic Sodium Phosphate Tablets prescribing information
- Sodium Phosphates (FDA)
Other brands
Related treatment guides
Further information
Sodium biphosphate/sodium phosphate side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.
