Skelid Side Effects

Generic Name: tiludronate

Note: This document contains side effect information about tiludronate. Some of the dosage forms listed on this page may not apply to the brand name Skelid.

For the Consumer

Applies to tiludronate: oral tablet

Along with its needed effects, tiludronate (the active ingredient contained in Skelid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tiludronate:

• Cough
• fever
• head congestion
• hoarseness or other voice changes
• nasal congestion
• runny nose
• sneezing
• sore throat

• Blindness
• blurred or decreased vision
• burning, dry, or itching eyes
• chest pain
• discharge or excessive tearing
• eye pain
• headache
• redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
• swelling of the face, feet, or lower legs
• unusual weight gain

• Bladder pain
• blistering, peeling, or loosening of the skin
• bloody or cloudy urine
• difficult, burning, or painful urination
• dizziness or lightheadedness
• fainting
• feeling of constant movement of self or surroundings
• frequent urge to urinate
• headache
• itching red skin lesions, often with a purple center
• lower back or side pain
• nervousness
• pain or swelling in the arms or legs without any injury
• pounding in the ears
• sensation of spinning
• slow or fast heartbeat
• sores, ulcers, or white spots in the mouth or on the lips

Get emergency help immediately if any of the following symptoms of overdose occur while taking tiludronate:

• Abdominal or stomach cramps
• confusion
• convulsions
• difficulty with breathing
• irregular heartbeats
• mood or mental changes
• muscle cramps in the hands, arms, feet, legs, or face
• numbness and tingling around the mouth, fingertips, or feet
• shortness of breath
• tremor

Some side effects of tiludronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Back pain
• body pain (general)
• diarrhea
• nausea
• upset stomach

• Bone fractures
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• confusion
• difficulty having a bowel movement (stool)
• dizziness
• dry skin
• hair loss
• increased thirst
• increased urination
• joint pain
• loss of appetite
• muscle cramps or spasms
• muscle pain
• red or irritated eyes
• skin rash
• stomach gas
• throat pain
• tooth disorder
• trouble thinking
• vomiting

• Dry mouth
• fear or nervousness
• feeling of warmth
• lack or loss of strength
• redness of the face, neck, arms and occasionally, upper chest
• sleepiness or unusual drowsiness
• stomach pain
• sleeplessness
• trouble sleeping
• unable to sleep
• unusual tiredness or weakness

For Healthcare Professionals

Applies to tiludronate: oral tablet

General

The most frequently occurring adverse reactions reported were: Diarrhea (9.3%), nausea (9.3%), and dyspepsia (5.3%).^[Ref]

Cardiovascular

Common (1% to 10%): Hypertension, flushing^[Ref]

Dermatologic

Common (1% to 10%): Rash, skin disorder, pruritus, increased sweating^[Ref]

Endocrine

Common (1% to 10%): Hyperparathyroidism^[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, nausea, dyspepsia, vomiting, flatulence, tooth disorder, abdominal pain, constipation, dry mouth gastritis^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection^[Ref]

Metabolic

Common (1% to 10%): Vitamin D deficiency, anorexia^[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia, back pain, arthrosis, fracture pathological, skeletal pain
Postmarketing reports: Atypical subtrochanteric and diaphyseal femoral fractures have been reported with bisphosphonate therapy, including this drug^[Ref]

Bone, joint, and/or muscle pain, rarely severe and/or incapacitating have been reported.^[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, paresthesia, vertigo, involuntary muscle contractions, somnolence, nervousness^[Ref]

Ocular

Common (1% to 10%): Cataract, conjunctivitis, glaucoma^[Ref]

Other

Common (1% to 10%): Pain, accidental injury, influenza like symptoms, chest pain, peripheral edema, infection, asthenia, syncope, fatigue^[Ref]

Psychiatric

Common (1% to 10%): Insomnia, anxiety^[Ref]

Respiratory

Common (1% to 10%): Rhinitis, sinusitis, upper respiratory tract infection, coughing, pharyngitis, bronchitis^[Ref]

Hypersensitivity

Rare (less than 0.1%): Stevens-Johnson syndrome^[Ref]

Some side effects of Skelid may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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