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Skelid Side Effects

Generic Name: tiludronate

Note: This document contains side effect information about tiludronate. Some of the dosage forms listed on this page may not apply to the brand name Skelid.

For the Consumer

Applies to tiludronate: oral tablet

Along with its needed effects, tiludronate (the active ingredient contained in Skelid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tiludronate:

More common Less common
  • Blindness
  • blurred or decreased vision
  • burning, dry, or itching eyes
  • chest pain
  • discharge or excessive tearing
  • eye pain
  • headache
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • swelling of the face, feet, or lower legs
  • unusual weight gain
  • Bladder pain
  • blistering, peeling, or loosening of the skin
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • dizziness or lightheadedness
  • fainting
  • feeling of constant movement of self or surroundings
  • frequent urge to urinate
  • headache
  • itching red skin lesions, often with a purple center
  • lower back or side pain
  • nervousness
  • pain or swelling in the arms or legs without any injury
  • pounding in the ears
  • sensation of spinning
  • slow or fast heartbeat
  • sores, ulcers, or white spots in the mouth or on the lips

Get emergency help immediately if any of the following symptoms of overdose occur while taking tiludronate:

Symptoms of overdose
  • Abdominal or stomach cramps
  • confusion
  • convulsions
  • difficulty with breathing
  • irregular heartbeats
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth, fingertips, or feet
  • shortness of breath
  • tremor

Some side effects of tiludronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Less common
  • Bone fractures
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • difficulty having a bowel movement (stool)
  • dizziness
  • dry skin
  • hair loss
  • increased thirst
  • increased urination
  • joint pain
  • loss of appetite
  • muscle cramps or spasms
  • muscle pain
  • red or irritated eyes
  • skin rash
  • stomach gas
  • throat pain
  • tooth disorder
  • trouble thinking
  • vomiting
  • Dry mouth
  • fear or nervousness
  • feeling of warmth
  • lack or loss of strength
  • redness of the face, neck, arms and occasionally, upper chest
  • sleepiness or unusual drowsiness
  • stomach pain
  • sleeplessness
  • trouble sleeping
  • unable to sleep
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to tiludronate: oral tablet


The most frequently occurring adverse reactions reported were: Diarrhea (9.3%), nausea (9.3%), and dyspepsia (5.3%).[Ref]


Common (1% to 10%): Hypertension, flushing[Ref]


Common (1% to 10%): Rash, skin disorder, pruritus, increased sweating[Ref]


Common (1% to 10%): Hyperparathyroidism[Ref]


Common (1% to 10%): Diarrhea, nausea, dyspepsia, vomiting, flatulence, tooth disorder, abdominal pain, constipation, dry mouth gastritis[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Vitamin D deficiency, anorexia[Ref]


Common (1% to 10%): Arthralgia, back pain, arthrosis, fracture pathological, skeletal pain
Postmarketing reports: Atypical subtrochanteric and diaphyseal femoral fractures have been reported with bisphosphonate therapy, including this drug[Ref]

Bone, joint, and/or muscle pain, rarely severe and/or incapacitating have been reported.[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, paresthesia, vertigo, involuntary muscle contractions, somnolence, nervousness[Ref]


Common (1% to 10%): Cataract, conjunctivitis, glaucoma[Ref]


Common (1% to 10%): Pain, accidental injury, influenza like symptoms, chest pain, peripheral edema, infection, asthenia, syncope, fatigue[Ref]


Common (1% to 10%): Insomnia, anxiety[Ref]


Common (1% to 10%): Rhinitis, sinusitis, upper respiratory tract infection, coughing, pharyngitis, bronchitis[Ref]


Rare (less than 0.1%): Stevens-Johnson syndrome[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Skelid (tilundronate)." Sanofi Winthrop Pharmaceuticals, New York, NY.

4. Lourwood DL "The pharmacology and therapeutic utility of bisphosphonates." Pharmacotherapy 18 (1998): 779-89

5. Roux C, Listrat V, Villette B, Lessana-Leibowitch M, Ethgen D, Pelissier C, Dougados M, Amor B "Long-lasting dermatological lesions after tiludronate therapy." Calcif Tissue Int 50 (1992): 378-80

6. Reginster JY, Lecart MP, Deroisy R, Ethgen D, Zegels B, Franchimont P "Paget's disease of bone treated with a five day course of oral tiludronate." Ann Rheum Dis 52 (1993): 54-7

7. Fraser WD, Stamp TC, Creek RA, Sawyer JP, Picot C "A double-blind, multicentre, placebo-controlled study of tiludronate in Paget's disease of bone." Postgrad Med J 73 (1997): 496-502

Some side effects of Skelid may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.