Skelid Side Effects

Generic name: tiludronate

Medically reviewed by Drugs.com. Last updated on May 31, 2025.

Note: This document provides detailed information about Skelid Side Effects associated with tiludronate. Some dosage forms listed on this page may not apply specifically to the brand name Skelid.

Applies to tiludronate: oral tablet.

Get emergency medical help if you have any of these signs of an allergic reaction while taking tiludronate (the active ingredient contained in Skelid): hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using tiludronate and call your doctor at once if you have any of these serious side effects:

• painful or difficult swallowing;

• severe heartburn, burning pain in your upper stomach, or coughing up blood;

• severe joint, bone, or muscle pain;

• jaw pain, numbness, or swelling;

• severe diarrhea;

• bone fracture; or

• a red, blistering, peeling skin rash.

Less serious side effects of tiludronate may include:

• nausea, vomiting, upset stomach;

• mild diarrhea; or

• runny or stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

See also:

For healthcare professionals

Applies to tiludronate: oral tablet.

General adverse events

The most frequently occurring adverse reactions reported were: Diarrhea (9.3%), nausea (9.3%), and dyspepsia (5.3%).^[Ref]

Cardiovascular

• Common (1% to 10%): Hypertension, flushing^[Ref]

Dermatologic

• Common (1% to 10%): Rash, skin disorder, pruritus, increased sweating^[Ref]

Endocrine

• Common (1% to 10%): Hyperparathyroidism^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea, nausea, dyspepsia, vomiting, flatulence, tooth disorder, abdominal pain, constipation, dry mouth gastritis^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Metabolic

• Common (1% to 10%): Vitamin D deficiency, anorexia^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia, back pain, arthrosis, fracture pathological, skeletal pain
• Postmarketing reports: Atypical subtrochanteric and diaphyseal femoral fractures have been reported with bisphosphonate therapy, including this drug^[Ref]

Bone, joint, and/or muscle pain, rarely severe and/or incapacitating have been reported.^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness, paresthesia, vertigo, involuntary muscle contractions, somnolence, nervousness^[Ref]

Ocular

• Common (1% to 10%): Cataract, conjunctivitis, glaucoma^[Ref]

Other

• Common (1% to 10%): Pain, accidental injury, influenza like symptoms, chest pain, peripheral edema, infection, asthenia, syncope, fatigue^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia, anxiety^[Ref]

Respiratory

• Common (1% to 10%): Rhinitis, sinusitis, upper respiratory tract infection, coughing, pharyngitis, bronchitis^[Ref]

Hypersensitivity

• Rare (less than 0.1%): Stevens-Johnson syndrome^[Ref]

Further information

Skelid side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer