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Rucaparib Side Effects

For the Consumer

Applies to rucaparib: oral tablet

Along with its needed effects, rucaparib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rucaparib:

More common
  • Black, tarry stools
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • sore throat
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Bleeding gums
  • pinpoint red spots on the skin
Less common or rare
  • Bone pain
  • chest pain
  • hoarseness
  • swollen glands
  • Difficult or labored breathing
  • tightness in the chest

Some side effects of rucaparib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dizziness
  • increased sensitivity of the skin to sunlight
  • itching or skin rash
  • lack or loss of strength
  • redness or other discoloration of the skin
  • severe sunburn
Less common
  • Abdominal or stomach pain
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement (stool)
  • nausea
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • tingling of the hands and feet
  • Change in taste
  • loss of taste

For Healthcare Professionals

Applies to rucaparib: oral tablet


-The most common adverse reactions reported in at least 20% of patients were nausea, asthenia/fatigue, vomiting, anemia, constipation, dysgeusia, decreased appetite, diarrhea, abdominal pain, dyspnea, and thrombocytopenia.
-The most common laboratory abnormalities reported in at least 35% of patients were increased creatinine, increased ALT, increased AST, decreased hemoglobin, decreased lymphocytes, increased cholesterol, decreased platelets, and decreased absolute neutrophil count.
-Adverse reactions led to dose reduction or interruption in 62% of patients (most frequently from anemia [27%] and asthenia/fatigue [22%]), and to dose discontinuation in 10% of patients (most frequently from asthenia/fatigue [2%]).[Ref]


Very common (10% or more): Increased creatinine (92%)[Ref]


Very common (10% or more): Nausea (77%), vomiting (46%), constipation (40%), diarrhea (34%), abdominal pain (32%)[Ref]


Very common (10% or more): Asthenia/fatigue (77%), pyrexia (11%)[Ref]


Very common (10% or more): Increased ALT (74%), increased AST (73%)[Ref]


Very common (10% or more): Decreased hemoglobin (67%), decreased lymphocytes (45%), anemia (44%), decreased platelets (39%), decreased absolute neutrophil count (35%), thrombocytopenia (21%), neutropenia (15%)
Common (1% to 10%): Febrile neutropenia[Ref]


Very common (10% or more): Decreased appetite (39%), increased cholesterol (40%)[Ref]

Nervous system

Very common (10% or more): Dysgeusia (39%), dizziness (17%)[Ref]


Very common (10% or more): Dyspnea (21%)[Ref]


Very common (10% or more): Dermatitis/Rash (13%), photosensitivity reaction (10%)
Common (1% to 10%): Pruritus, palmar-plantar erythrodysesthesia syndrome[Ref]


Uncommon (0.1% to 1%): Myelodysplastic syndrome, acute myeloid leukemia[Ref]


1. "Product Information. Rubraca (rucaparib)." Clovis Oncology Inc, Boulder, CO.

Some side effects of rucaparib may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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