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rucaparib (Oral route)


Commonly used brand name(s)

In the U.S.

  • Rubraca

Available Dosage Forms:

  • Tablet

Therapeutic Class: Antineoplastic Agent

Uses For rucaparib

Rucaparib is used to treat advanced ovarian cancer in patients who have who have received 2 or more cancer medicines. It is only used in patients who have deleterious BRCA mutation. Your doctor will use a test to check for the mutation before you receive the medicine.

rucaparib is available only with your doctor's prescription.

Before Using rucaparib

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rucaparib, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to rucaparib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of rucaparib in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rucaparib in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of rucaparib. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood or bone marrow problems—Use with caution. May make these conditions worse.

Proper Use of rucaparib

Medicines used to treat cancer are very strong and can have many side effects. Before receiving rucaparib, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Take rucaparib exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

rucaparib should come with patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

You may take rucaparib with or without food.


The dose of rucaparib will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of rucaparib. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For advanced ovarian cancer:
      • Adults—At first, 600 milligrams (mg) (two 300 mg tablets) two times a day (approximately 12 hours apart). Your doctor may adjust your dose as needed.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of rucaparib, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you vomit after taking a dose, do not take an extra dose.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using rucaparib

If you will be taking rucaparib for a long time, it is very important that your doctor check you at regular visits for any problems or unwanted effects that may be caused by rucaparib. Blood tests may be needed to check for unwanted effects.

Using rucaparib while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during therapy and for 6 months after the last dose of rucaparib. If you think you have become pregnant while using the medicine, tell your doctor right away.

Tell your doctor if you have a bone pain, blood in the urine or stools, fever or chills, cough, sore throat, trouble breathing, unusual bleeding or bruising, or unusual tiredness or weakness. These may be symptoms of a bone marrow problem called myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).

rucaparib may make your skin more sensitive to sunlight. Use sunscreen or sunblock lotions and lip balms with a sun protection factor (SPF) of at least 30 on a regular basis when you are outdoors. Wear protective clothing and hats and stay out of direct sunlight, especially between the hours of 10 AM and 3 PM. Avoid sunlamps and tanning beds.

rucaparib Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Black, tarry stools
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • sore throat
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Bleeding gums
  • pinpoint red spots on the skin
Less common or rare
  • Bone pain
  • chest pain
  • hoarseness
  • swollen glands
  • Difficult or labored breathing
  • tightness in the chest

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dizziness
  • increased sensitivity of the skin to sunlight
  • itching or skin rash
  • lack or loss of strength
  • redness or other discoloration of the skin
  • severe sunburn
Less common
  • Abdominal or stomach pain
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement (stool)
  • nausea
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • tingling of the hands and feet
  • Change in taste
  • loss of taste

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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