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Ragwitek Side Effects

Generic Name: ragweed pollen allergen extract

Note: This page contains side effects data for the generic drug ragweed pollen allergen extract. It is possible that some of the dosage forms included below may not apply to the brand name Ragwitek.

For the Consumer

Applies to ragweed pollen allergen extract: sublingual tablet

As well as its needed effects, ragweed pollen allergen extract (the active ingredient contained in Ragwitek) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking ragweed pollen allergen extract, check with your doctor immediately:

More common:
  • Itching of the ears, mouth, and tongue
  • numbness or tingling feeling around the mouth
  • swelling of the mouth
Less common:
  • Difficulty swallowing
  • discomfort in the chest
  • itching skin
  • redness, swelling, or soreness of the tongue or in the mouth
Incidence not known:
  • Cough
  • dizziness
  • fast heartbeat
  • hives or skin rash
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • sweating
  • tightness in the chest

Minor Side Effects

Some ragweed pollen allergen extract side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Dry mouth
  • nausea

For Healthcare Professionals

Applies to ragweed pollen allergen extract: sublingual tablet


The most common side effects reported were throat irritation, oral pruritus, ear pruritus, oral paresthesia, mouth edema, and tongue pruritus.[Ref]


Frequency not reported: Systemic allergic reactions (including anaphylaxis)[Ref]


Very common (10% or more): Throat irritation (up to 16.6%)
Common (1% to 10%): Oropharyngeal pain, throat tightness[Ref]


Common (1% to 10%): Chest discomfort[Ref]


Common (1% to 10%): Pruritus[Ref]


Very common (10% or more): Oral pruritus (10.9%), Oral paresthesia (10%)
Common (1% to 10%): Mouth edema, tongue pruritus, lip swelling, swollen tongue, lip pruritus, dry mouth, tongue edema, nausea, palatal edema, dysphagia[Ref]


Very common (10% or more): Ear pruritus (10.4%)[Ref]


1. "Product Information. Ragwitek (ragweed pollen allergen extract)." Merck & Company Inc, Whitehouse Station, NJ.

It is possible that some side effects of Ragwitek may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.