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Pulmicort Nebuamp Side Effects

Generic Name: budesonide

Note: This page contains side effects data for the generic drug budesonide. It is possible that some of the dosage forms included below may not apply to the brand name Pulmicort Nebuamp.

For the Consumer

Applies to budesonide: oral capsule delayed release, oral capsule extended release, oral tablet extended release

As well as its needed effects, budesonide (the active ingredient contained in Pulmicort Nebuamp) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking budesonide, check with your doctor immediately:

More common:
  • Bruising easily
  • chills
  • colds
  • cough or hoarseness
  • fever
  • flu-like symptoms
  • sneezing
  • sore throat
Less common:
  • Abdominal or stomach pain
  • bladder pain
  • bleeding after defecation
  • bloody or cloudy urine
  • blurred vision
  • burning while urinating
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • convulsions
  • cough producing mucus
  • decreased urine
  • diarrhea
  • difficult or labored breathing
  • difficult or painful urination
  • dizziness
  • dry mouth
  • eye pain
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth
  • general feeling of discomfort or illness
  • headache
  • heartburn
  • increase in body movements
  • increased thirst
  • increased urge to urinate during the night
  • irregular heartbeat
  • joint pain
  • loss of appetite
  • lower back or side pain
  • mood changes
  • muscle aches and pains
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the chest, upper stomach, or throat
  • pounding in the ears
  • rectal bleeding
  • redness of the face, neck, arms, and occasionally, upper chest
  • runny nose
  • severe constipation
  • shakiness in the legs, arms, hands, or feet
  • shivering
  • slow or fast heartbeat
  • stomach cramps
  • sweating
  • swelling of the legs and feet
  • swelling or puffiness of the face
  • tightness in the chest
  • trouble sleeping
  • uncomfortable swelling around the anus
  • unusual tiredness or weakness
  • upper abdominal or stomach pain
  • waking to urinate at night
  • weight gain
  • weight loss
Incidence not known:
  • Bulging soft spot on the head of an infant
  • change in the ability to see colors, especially blue or yellow
  • difficulty with swallowing
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash

Minor Side Effects

Some budesonide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Acid or sour stomach
  • belching
  • blemishes on the skin
  • heartburn
  • indigestion
  • pain or tenderness around the eyes and cheekbones
  • pimples
  • rounded or moon face
  • stomach discomfort, upset, or pain
  • stuffy nose
Less common:
  • Accumulation of pus
  • agitation
  • blistering, crusting, irritation, itching, or reddening of the skin
  • bloated or full feeling
  • change in hearing
  • changes in vision
  • cracked, dry, or scaly skin
  • cracks in the skin at the corners of mouth
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dizziness or lightheadedness
  • ear drainage
  • earache or pain in the ear
  • excess air or gas in the stomach or intestines
  • feeling of constant movement of self or surroundings
  • hair loss or thinning of the hair
  • increased appetite
  • increased hair growth, especially on the face
  • lack or loss of strength
  • loss of memory
  • muscle pains or stiffness
  • nervousness
  • pain, swelling, or redness in the joints
  • passing gas
  • pinpoint red or purple spots on the skin
  • pressure in the stomach
  • problems with memory
  • redness, swelling, or soreness of the tongue
  • sensation of spinning
  • skin rash
  • skin rash, encrusted, scaly, and oozing
  • sleepiness or unusual drowsiness
  • sleeplessness
  • soreness or redness around the fingernails and toenails
  • swelling of the abdominal or stomach area
  • swollen joints
  • unable to sleep
  • uterine bleeding between menstrual periods

For Healthcare Professionals

Applies to budesonide: compounding powder, inhalation powder, inhalation suspension, oral capsule extended release, oral tablet extended release, rectal foam


The most commonly reported adverse events with inhaled use have included nasopharyngitis, nasal congestion pharyngitis, rhinitis, and oral candidiasis. Headache, nausea, abdominal pain, and fatigue have been commonly reported with oral and rectal use. Due to the nature of its administration (inhalation, gastro-protective oral formulations, and rectal enema), it is less likely to cause systemic adverse effects associated with the use of corticosteroids.[Ref]


Epidemiological studies have shown an increased incidence of pneumonia in patients with chronic obstructive pulmonary disease (COPD) treated with inhaled corticosteroids.[Ref]

Very common (10% or more): Respiratory infection (up to 13%)
Common (1% to 10%): Nasopharyngitis, nasal congestion, pharyngitis, allergic rhinitis, viral upper respiratory tract infection, epistaxis, cough, dysphonia, hoarseness
Frequency not reported: Bronchitis, dyspnea, pharynx disorder, pneumonia
Postmarketing reports: Throat irritation, sinusitis[Ref]


Deaths due to adrenal insufficiency have been reported in asthmatic patients during and after transferring from systemic corticosteroids to less systemically available inhaled corticosteroids.[Ref]

Common (1% to 10%): Decreased blood cortisol, moon face
Uncommon (0.1% to 1%): Hirsutism, Cushingoid syndrome
Frequency not reported: Intermenstrual bleeding, menstrual disorder, HPA axis suppression, deaths due to adrenal insufficiency
Postmarketing reports: Hypocorticism[Ref]


Common (1% to 10%): Oral candidiasis
Frequency not reported: Immunosuppression, abscess[Ref]


Very common (10% or more): Nausea (up to 13%); abdominal pain (21%)
Common (1% to 10%): Viral gastroenteritis, upper abdominal pain, flatulence, abdominal distension, constipation, dyspepsia, vomiting, diarrhea, sore/irritated throat, dry mouth, bad taste, rectal disorder, rectal hemorrhage, ulcerative colitis, burning in the rectum or pain
Frequency not reported: Anus disorder, enteritis, epigastric pain, gastrointestinal fistula, glossitis, hemorrhoids, intestinal obstruction, tongue edema, tooth disorder
Postmarketing reports: Pancreatitis[Ref]

Nervous system

Very common (10% or more): Headache (up to 28%)
Common (1% to 10%): Dizziness
Uncommon (0.1% to 1%): Disturbance of smell
Very rare (less than 0.01%): Pseudotumor cerebri (including papilledema)
Frequency not reported: Hyperkinesia, paresthesia, tremor, somnolence
Postmarketing reports: Benign intracranial hypertension[Ref]


Common (1% to 10%): Mood changes, sleep changes, insomnia,
Frequency not reported: Amnesia
Postmarketing reports: Psychosis, depression, aggressive reactions, irritability, nervousness, restlessness, anxiety, mood swings[Ref]


Frequency not reported: Hypersensitivity reactions including anaphylaxis, rash, contact dermatitis, urticaria, angioedema, bronchospasm
Postmarketing reports: Cough, wheezing, bronchospasm[Ref]


Common (1% to 10%): Arthralgia, back pain
Very rare (less than 0.01%): Osteoporosis, aseptic necrosis of bone (femur and head of the humerus)
Frequency not reported: Bone mineral density reductions, arthritis, cramps, myalgia, growth suppression[Ref]

Long-term studies in clinical practice suggest that children treated with inhaled drug generally achieve adult height. However, in a long-term study in which inhaled drug dose was not titrated to the lowest effective dose, children were found to be 1.2 cm shorter as adults than those randomized to placebo.[Ref]


Common (1% to 10%): Fluid retention, palpitation
Uncommon (0.1% to 1%): Hypertension
Frequency not reported: Tachycardia, chest pain, dependent edema, flushing[Ref]


Frequency not reported: Weight gain, increased appetite, hypokalemia[Ref]


Common (1% to 10%): Leukocytosis
Uncommon (0.1% to 1%): Anemia
Rare (0.01% to 0.1%): Eosinophilic conditions, Churg-Strauss[Ref]


Common (1% to 10%): Conjunctivitis
Frequency not reported: Eye abnormality, abnormal vision
Postmarketing reports: Glaucoma, cataracts, increased intraocular pressure[Ref]


Common (1% to 10%): Urinary tract infection, moniliasis
Frequency not reported: Dysuria, micturition frequency, nocturia[Ref]


Common (1% to 10%): Acne, rash, contact dermatitis, eczema, pustular rash, pruritus, purpura
Very rare (less than 0.01%): Allergic exanthema, red striae, petechiae, ecchymosis, delayed wound healing
Frequency not reported: Face edema, alopecia, dermatitis, eczema, skin disorder, increased sweating, purpura
Postmarketing reports: Skin bruising[Ref]


Uncommon (0.1% to 1%): Increase in liver enzymes[Ref]


Common (1% to 10%): Otitis media, fatigue, earache
Frequency not reported: Asthenia, malaise, fever, flu-like disorder, vertigo[Ref]


1. "Product Information. Pulmicort Flexhaler (budesonide)." A-S Medication Solutions, Chicago, IL.

2. "Product Information. Pulmicort Respules (budesonide)." Astra-Zeneca Pharmaceuticals, Wayne, PA.

3. "Product Information. Entocort (budesonide)." AstraZeneca Pharma Inc, Mississauga, ON.

4. "Product Information. Entocort EC (budesonide)." Perrigo, L. Company, Allegan, MI.

5. "Product Information. Uceris (budesonide)." Santarus Inc, San Diego, CA.

It is possible that some side effects of Pulmicort Nebuamp may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.