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Pramlintide Side Effects

Medically reviewed by Drugs.com. Last updated on May 26, 2022.

For the Consumer

Applies to pramlintide: subcutaneous solution

Warning

Subcutaneous route (Solution)

Severe hypoglycemia has occurred within 3 hours of pramlintide injection when used concomitantly with insulin, especially in patients with type 1 diabetes. Serious injuries may happen if hypoglycemia occurs during high-risk activities, and appropriate patient selection, instruction, and insulin dose reduction are critical for reducing this risk.

Side effects requiring immediate medical attention

Along with its needed effects, pramlintide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pramlintide:

More common

Side effects not requiring immediate medical attention

Some side effects of pramlintide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty with moving
  • inflicted injury
  • loss of appetite
  • muscle pain or stiffness
  • pain in the joints
  • stomach pain
  • vomiting
  • weight loss

Less common

  • Body aches or pain
  • congestion
  • dryness or soreness of the throat
  • fever
  • hoarseness
  • runny nose
  • tender, swollen glands in the neck
  • voice changes

For Healthcare Professionals

Applies to pramlintide: subcutaneous solution

Metabolic

Very common (10% or more): Severe hypoglycemia (up to 16.8%), anorexia (up to 17%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 48%), vomiting (up to 11%)

Common (1% to 10%): Abdominal pain

Frequency not reported: Slower gastric emptying

Postmarketing reports: Pancreatitis[Ref]

Hypersensitivity

Common (1% to 10%): Allergic reaction[Ref]

Nervous system

Very common (10% or more): Headache

Common (1% to 10%): Dizziness[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia[Ref]

Respiratory

Common (1% to 10%): Cough, pharyngitis[Ref]

General

The most commonly reported side effects were: nausea, vomiting, and severe hypoglycemia.[Ref]

Local

Postmarketing reports: Injection site reactions[Ref]

Other

Very common (10% or more): Inflicted injury (14%)

Common (1% to 10%): Fatigue[Ref]

References

1. "Product Information. Symlin (pramlintide)." Amphastar Pharmaceuticals Inc (2005):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer