Pramlintide Side Effects

For the Consumer

Applies to pramlintide: subcutaneous solution

As well as its needed effects, pramlintide may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking pramlintide, check with your doctor immediately:

• Anxiety
• blurred vision
• chills
• cold sweats
• coma
• confusion
• cool pale skin
• cough
• depression
• difficulty with swallowing
• dizziness
• fast heartbeat
• headache
• hives, itching, or skin rash
• increased hunger
• nausea
• nightmares
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• seizures
• shakiness
• slurred speech
• tightness in the chest
• unusual tiredness or weakness

Minor Side Effects

Some pramlintide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

• Difficulty with moving
• inflicted injury
• loss of appetite
• muscle pain or stiffness
• pain in the joints
• stomach pain
• vomiting
• weight loss

• Body aches or pain
• congestion
• dryness or soreness of the throat
• fever
• hoarseness
• runny nose
• tender, swollen glands in the neck
• voice changes

For Healthcare Professionals

Applies to pramlintide: subcutaneous solution

Metabolic

Very common (10% or more): Severe hypoglycemia (up to 16.8%), anorexia (up to 17%)^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 48%), vomiting (up to 11%)
Common (1% to 10%): Abdominal pain
Frequency not reported: Slower gastric emptying
Postmarketing reports: Pancreatitis^[Ref]

Hypersensitivity

Common (1% to 10%): Allergic reaction^[Ref]

Nervous system

Very common (10% or more): Headache
Common (1% to 10%): Dizziness^[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia^[Ref]

Respiratory

Common (1% to 10%): Cough, pharyngitis^[Ref]

General

The most commonly reported side effects were: nausea, vomiting, and severe hypoglycemia.^[Ref]

Local

Postmarketing reports: Injection site reactions^[Ref]

Other

Very common (10% or more): Inflicted injury (14%)
Common (1% to 10%): Fatigue^[Ref]

It is possible that some side effects of pramlintide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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