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Pramlintide Side Effects

For the Consumer

Applies to pramlintide: subcutaneous solution

Along with its needed effects, pramlintide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pramlintide:

More common
  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • cool pale skin
  • cough
  • depression
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • headache
  • hives, itching, or skin rash
  • increased hunger
  • nausea
  • nightmares
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • shakiness
  • slurred speech
  • tightness in the chest
  • unusual tiredness or weakness

Some side effects of pramlintide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty with moving
  • inflicted injury
  • loss of appetite
  • muscle pain or stiffness
  • pain in the joints
  • stomach pain
  • vomiting
  • weight loss
Less common
  • Body aches or pain
  • congestion
  • dryness or soreness of the throat
  • fever
  • hoarseness
  • runny nose
  • tender, swollen glands in the neck
  • voice changes

For Healthcare Professionals

Applies to pramlintide: subcutaneous solution

Metabolic

Very common (10% or more): Severe hypoglycemia (up to 16.8%), anorexia (up to 17%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 48%), vomiting (up to 11%)
Common (1% to 10%): Abdominal pain
Frequency not reported: Slower gastric emptying
Postmarketing reports: Pancreatitis[Ref]

Hypersensitivity

Common (1% to 10%): Allergic reaction[Ref]

Nervous system

Very common (10% or more): Headache
Common (1% to 10%): Dizziness[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia[Ref]

Respiratory

Common (1% to 10%): Cough, pharyngitis[Ref]

General

The most commonly reported side effects were: nausea, vomiting, and severe hypoglycemia.[Ref]

Local

Postmarketing reports: Injection site reactions[Ref]

Other

Very common (10% or more): Inflicted injury (14%)
Common (1% to 10%): Fatigue[Ref]

References

1. "Product Information. Symlin (pramlintide)." Amphastar Pharmaceuticals Inc, South El Monte, CA.

Some side effects of pramlintide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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