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Poly-Tussin D Side Effects

Generic Name: chlorcyclizine / codeine / pseudoephedrine

Note: This document contains side effect information about chlorcyclizine / codeine / pseudoephedrine. Some of the dosage forms listed on this page may not apply to the brand name Poly-Tussin D.

Applies to chlorcyclizine / codeine / pseudoephedrine: oral liquid

General

The most common side effects may include drowsiness, dizziness, dry mouth, and nervousness.[Ref]

Respiratory

Frequency not reported: Respiratory depression

Psychiatric

Frequency not reported: Excitability, nervousness, insomnia

Nervous system

Frequency not reported: Drowsiness[Ref]

Cardiovascular

Frequency not reported: Hypotension, dizziness[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, constipation , dry mouth[Ref]

Genitourinary

Frequency not reported: Urinary retention[Ref]

Ocular

Frequency not reported: Blurred vision[Ref]

Dermatologic

Frequency not reported: Rashes, severe scarlatiniform eruptions, generalized dermatitis[Ref]

References

1. "American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults." J Am Geriatr Soc 63 (2015): 2227-46

2. Shorr RI, Griffin MR, Daugherty JR, Ray WA "Opioid analgesics and the risk of hip fracture in the elderly: codeine and propoxyphene." J Gerontol 47 (1992): m111-5

3. Zolezzi M, Al Mohaimeed SA "Seizures with intravenous codeine phosphate." Ann Pharmacother 35 (2001): 1211-3

4. de Groot AC, Conemans J "Allergic urticarial rash from oral codeine." Contact Dermatitis 14 (1986): 209-14

5. Max MB, Schafer SC, Culnane M, et al "Association of pain relief with drug side effects in postherpeticneuralgia: a single-dose study of clonidine, codeine, ibuprofen, and placebo." Clin Pharmacol Ther 43 (1988): 363-71

6. Bradley CM, Nicholson AN "Effects of a mu-opoiod receptor agonist (codeine phosphate) on visuo-motor coordination and dynamic visual acuity in man." Br J Clin Pharmacol 22 (1986): 507-12

7. Redpath JB, Pleuvry BJ "Double-blind comparison of the respiratory and sedative effects of codeine phosphate and (+/-)-glaucine phosphate in human volunteers." Br J Clin Pharmacol 14 (1982): 555-8

8. Cox RG "Hypoxaemia and hypotension after intravenous codeine phosphate." Can J Anaesth 41 (1994): 1211-3

9. "Product Information. Notuss-NXD (chlorcyclizine / codeine / pseudoephedrine)." SJ Pharmaceuticals formerly Stewart-Jackson Pharmacal Inc, Atlanta, GA.

10. Malek-Ahmadi P, Ramsey ML "Acute psychosis associated with codeine and acetaminophen: a case report." Neurobehav Toxicol Teratol 7 (1985): 193-4

11. Stambaugh JE Jr, McAdams J "Comparison of the analgesic efficacy and safety of oral ciramadol, codeine, and placebo in patients with chronic cancer pain." J Clin Pharmacol 27 (1987): 162-6

12. Parke TJ, Nandi PR, Bird KJ, Jewkes DA "Profound hypotension following intravenous codeine phosphate: three case reports and some recommendations." Anaesthesia 47 (1992): 852-4

13. Hastier P, Buckley MJM, Peten EP, Demuth N, Dumas R, Demarquay JF, CaroliBosc FX, Delmont JP "A new source of drug-induced acute pancreatitis: Codeine." Am J Gastroenterol 95 (2000): 3295-8

14. Stringer MD, Greenfield S, McIrvine AJ "Stercoral perforation of the colon following postoperative analgesia." J R Soc Med 80 (1987): 115-6

15. Knaggs RD, Crighton IM, Cobby TF, Fletcher AJ, Hobbs GJ "The pupillary effects of intravenous morphine, codeine, and tramadol in volunteers." Anesth Analg 99 (2004): 108-12

16. Gonzalogarijo MA, Revengaarranz F "Fixed drug eruption due to codeine." Br J Dermatol 135 (1996): 498-9

17. Rodriguez F, Fernandez L, Garciaabujeta JL, Maquiera E, Llaca HF, Jerez J "Generalized dermatitis due to codeine." Contact Dermatitis 32 (1995): 120

18. Hunskaar S, Dragsund S "Scarlatiniform rash and urticaria due to codeine." Ann Allergy 54 (1985): 240-1

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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