Skip to Content

Plerixafor Side Effects

In Summary

Commonly reported side effects of plerixafor include: injection site reaction, dizziness, diarrhea, nausea, headache, fatigue, arthralgia, and vomiting. Other side effects include: flatulence. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to plerixafor: subcutaneous solution

As well as its needed effects, plerixafor may cause unwanted side effects that require medical attention.

Severity: Major

If any of the following side effects occur while taking plerixafor, check with your doctor immediately:

More common:
  • Bleeding gums
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • collection of blood under skin
  • coughing up blood
  • deep, dark purple bruise
  • difficulty in breathing or swallowing
  • dizziness
  • feeling of heat
  • flushing, redness of the skin
  • hard lump
  • headache
  • hives or welts
  • increased menstrual flow or vaginal bleeding
  • irritation
  • itching skin
  • nosebleeds
  • pain
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • redness of the skin
  • shortness of breath
  • skin rash
  • swelling
  • unusually warm skin
Rare:
  • Chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • fainting
  • fast heartbeat
  • swelling around the eyes
  • tightness in the chest
  • weakness
  • wheezing

Severity: Minor

Some plerixafor side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Bloated
  • diarrhea
  • difficulty in moving
  • excess air or gas in stomach or intestines
  • full feeling
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • passing gas
  • sleeplessness
  • trouble sleeping
  • unable to sleep
  • unusual tiredness or weakness
  • vomiting
Less common:
  • Acid or sour stomach
  • belching
  • difficulty having a bowel movement (stool)
  • dry mouth
  • general feeling of discomfort or illness
  • heartburn
  • increased sweating
  • indigestion
  • muscle or bone pain
  • pressure in the stomach
  • stomach discomfort, upset, or pain
  • swelling of abdominal or stomach area

For Healthcare Professionals

Applies to plerixafor: subcutaneous solution

Gastrointestinal

Very common (10% or more): Diarrhea (up to 37%), nausea (up to 34%), vomiting (up to 10%)
Common (1% to 10%): Flatulence, abdominal pain, abdominal distension, dry mouth, stomach discomfort, hypoesthesia oral, constipation, dyspepsia[Ref]

Local

Very common (10% or more): Injection site reactions (up to 34%)[Ref]

Other

Very common (10% or more): Fatigue (up to 27%)
Common (1% to 10%): Malaise[Ref]

Nervous system

Very common (10% or more): Headache (up to 22%), paresthesia (up to 20.6%), dizziness (up to 11%)
Uncommon (0.1% to 1%): Vasovagal reactions[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (up to 13%)
Common (1% to 10%): Musculoskeletal pain[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis, erythema[Ref]

Hematologic

Common (1% to 10%): Hyperleukocytosis
Frequency not reported: Thrombocytopenia[Ref]

Psychiatric

Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Abnormal dreams, nightmares[Ref]

Immunologic

Uncommon (0.1% to 1%): Allergic reactions
Postmarketing reports: Anaphylactic reactions including anaphylactic shock[Ref]

Cardiovascular

Rare (less than 0.1%): Myocardial infarction[Ref]

References

1. "Product Information. Mozobil (plerixafor)." Genzyme Corporation, Cambridge, MA.

It is possible that some side effects of plerixafor may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide