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Plerixafor Side Effects

In Summary

Commonly reported side effects of plerixafor include: diarrhea, dizziness, injection site reaction, nausea, arthralgia, fatigue, headache, and vomiting. Other side effects include: flatulence. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to plerixafor: subcutaneous solution

Along with its needed effects, plerixafor may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking plerixafor:

More common
  • Bleeding gums
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • collection of blood under the skin
  • coughing up blood
  • deep, dark purple bruise
  • difficulty in breathing or swallowing
  • dizziness
  • feeling of heat
  • flushing, redness of the skin
  • hard lump
  • headache
  • hives or welts, itching, skin rash
  • increased menstrual flow or vaginal bleeding
  • irritation
  • nosebleeds
  • pain
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • swelling
  • unusually warm skin
Rare
  • Chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • fainting
  • fast heartbeat
  • swelling around the eyes
  • tightness in the chest
  • weakness
Incidence not known
  • Cough
  • feeling of fullness
  • pain in the left upper stomach or around the left shoulder
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • stomach pain
  • unusual tiredness or weakness

Some side effects of plerixafor may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bloated feeling
  • diarrhea
  • difficulty in moving
  • excess air or gas in the stomach or intestines
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • passing gas
  • trouble sleeping
  • vomiting
Less common
  • Belching
  • bone pain
  • difficulty having a bowel movement
  • dry mouth
  • general feeling of discomfort or illness
  • heartburn
  • increased sweating
  • indigestion
  • pressure in the stomach
  • stomach discomfort or upset
  • swelling of the abdominal or stomach area
Incidence not known

For Healthcare Professionals

Applies to plerixafor: subcutaneous solution

Gastrointestinal

Very common (10% or more): Diarrhea (up to 37%), nausea (up to 34%), vomiting (up to 10%)
Common (1% to 10%): Flatulence, abdominal pain, abdominal distension, dry mouth, stomach discomfort, hypoesthesia oral, constipation, dyspepsia[Ref]

Local

Very common (10% or more): Injection site reactions (up to 34%)[Ref]

Other

Very common (10% or more): Fatigue (up to 27%)
Common (1% to 10%): Malaise[Ref]

Nervous system

Very common (10% or more): Headache (up to 22%), paresthesia (up to 20.6%), dizziness (up to 11%)
Uncommon (0.1% to 1%): Vasovagal reactions[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (up to 13%)
Common (1% to 10%): Musculoskeletal pain[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis, erythema[Ref]

Hematologic

Common (1% to 10%): Hyperleukocytosis
Frequency not reported: Thrombocytopenia[Ref]

Psychiatric

Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Abnormal dreams, nightmares[Ref]

Immunologic

Uncommon (0.1% to 1%): Allergic reactions
Postmarketing reports: Anaphylactic reactions including anaphylactic shock[Ref]

Cardiovascular

Rare (less than 0.1%): Myocardial infarction[Ref]

References

1. "Product Information. Mozobil (plerixafor)." Genzyme Corporation, Cambridge, MA.

Some side effects of plerixafor may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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