Plerixafor Dosage
Medically reviewed by Drugs.com. Last updated on Oct 28, 2024.
Applies to the following strengths: 20 mg/mL
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for non-Hodgkin's Lymphoma
Dosing Based on Actual Patient Body Weight:
- 83 kg or Less:
- Greater than 83 kg and Less than 160 kg:
Duration of Therapy: Up to 4 consecutive days
Maximum Dose: 40 mg/day
Comments:
- The drug volume to be administered should be calculated using the following equation: 0.012 x actual patient body weight (kg) = administration dose (mL)
- The dosing has been calculated based on actual patient body weight up to 175% of ideal body weight; dosing and treatment of patients weighing more than 175% of ideal body weight have not been investigated.
- Granulocyte-colony stimulating factor (G-CSF) 10 mcg/kg should be administered once daily in the morning for 4 consecutive days prior to the first dose of this drug and on each morning prior to apheresis.
Use: Indicated in combination with G-CSF to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.
Usual Adult Dose for Multiple Myeloma
Dosing Based on Actual Patient Body Weight:
- 83 kg or Less:
- Greater than 83 kg and Less than 160 kg:
Duration of Therapy: Up to 4 consecutive days
Maximum Dose: 40 mg/day
Comments:
- The drug volume to be administered should be calculated using the following equation: 0.012 x actual patient body weight (kg) = administration dose (mL)
- The dosing has been calculated based on actual patient body weight up to 175% of ideal body weight; dosing and treatment of patients weighing more than 175% of ideal body weight have not been investigated.
- Granulocyte-colony stimulating factor (G-CSF) 10 mcg/kg should be administered once daily in the morning for 4 consecutive days prior to the first dose of this drug and on each morning prior to apheresis.
Use: Indicated in combination with G-CSF to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.
Renal Dose Adjustments
Moderate and Severe Renal Impairment (CrCl 50 mL/min or less):
Dosing Based on Actual Patient Body Weight:
- 83 kg or Less:
- Greater than 83 kg and Less than 160 kg:
Duration of Therapy: Up to 4 consecutive days
Maximum Dose: 27 mg/day
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS:
- Hypersensitivity to plerixafor; anaphylactic shock has occurred with use
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
- Hemodialysis: Insufficient data available to make dosage recommendation.
- Peritoneal dialysis: Data not available
Other Comments
Administration Advice:
- Subcutaneous injection to the abdomen was primarily used in clinical trials, but some patients received subcutaneous injections in the extremities.
- Prior to administration, each drug vial should be inspected visually and should not be used if there is particulate matter or if the solution is discolored.
Storage Requirements:
- Each drug vial is for single use only; any unused drug should be discarded.
Monitoring:
- Hematologic: White blood cell counts, platelet counts (during treatment and apheresis)
- Hypersensitivity/Immunologic: Signs/symptoms of hypersensitivity (during and after drug administration)
Patient Advice:
- This drug may cause side effects such as dizziness and fatigue that can affect your ability to perform certain activities; avoid driving and activities such as operating machinery until you know how this drug affects you.
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