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Hematopoietic stem cell mobilizer

What are Hematopoietic stem cell mobilizer

Hematopoietic stem cell mobilizer binds to the CXCR4 chemokine receptor and inhibits the binding of its ligand, stromal cell-derived factor-1-alpha (SDF-1-alpha). This leads to mobilization of hematopoietic stem cells to the peripheral blood. The hematopoietic stem cells (CD34+ cells) are collected from the peripheral blood and used for autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma. Hematopoietic stem cells produce all types of blood cells so autologous transplantation restores normal production of the blood cells.

List of Hematopoietic stem cell mobilizer:

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Mozobil (Pro, More...)
generic name: plerixafor
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Medical conditions associated with hematopoietic stem cell mobilizer: