Picato Side Effects

Generic Name: ingenol topical

Note: This page contains side effects data for the generic drug ingenol topical. It is possible that some of the dosage forms included below may not apply to the brand name Picato.

In Summary

Common side effects of Picato include: dermal ulcer, localized vesiculation, skin erosion, swelling of skin, and erythema. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ingenol topical: topical application gel/jelly

As well as its needed effects, ingenol topical (the active ingredient contained in Picato) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking ingenol topical, check with your doctor immediately:

• Blistering, peeling, or loosening of the skin
• pain and itching at the application site
• redness of the skin (severe)
• skin ulcers
• swelling of the skin

• Burning, dry, or itching eyes
• discharge or excessive tearing
• eye pain
• infection at the application site
• redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
• swelling around the eyes

Minor Side Effects

Some ingenol topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

• Flaking or scaling of the skin
• redness of the skin (mild)

• Headache

For Healthcare Professionals

Applies to ingenol topical: topical gel

General

The most commonly reported side effects were local skin responses including erythema, flaking/scaling, crusting, swelling, vesiculation/postulation, and erosion.^[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions^[Ref]

Local

Very common (10% or more): Application site erythema (up to 94%), application site exfoliation (up to 90%), application site scab (up to 80%), application site swelling (up to 79%), application site erosion/ulceration (up to 32%), application site vesicles (up to 20%), application site pain (including application site burning) (up to 15%)
Common (1% to 10%): Application site pruritus, application site irritation
Uncommon (0.1% to 1%): Application site discharge, application site paresthesia, application site ulcer, application site warmth^[Ref]

Dermatologic

Very common (10% or more): Flaking/scaling (85%), crusting (80%), vesiculation/postulation (56%)
Postmarketing reports: Allergic contact dermatitis^[Ref]

Immunologic

Very common (10% or more): Application site pustules (up to 43%)
Common (1% to 10%): Application site infection
Postmarketing reports: Herpes zoster^[Ref]

Nervous system

Common (1% to 10%): Headache^[Ref]

Ocular

Common (1% to 10%): Eye lid edema, periorbital edema
Uncommon (0.1% to 1%): Eyelid pain
Frequency not reported: Chemical conjunctivitis, corneal burn, eyelid ptosis^[Ref]

Other

Very common (10% or more): Swelling (79%)^[Ref]

It is possible that some side effects of Picato may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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