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Pegfilgrastim Side Effects

In Summary

Commonly reported side effects of pegfilgrastim include: ostealgia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pegfilgrastim: subcutaneous solution

Along with its needed effects, pegfilgrastim may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pegfilgrastim:

More common
  • Bluish lips or skin
  • pain, left upper abdomen or shoulder
  • tightness in the chest
  • troubled breathing
Incidence not known
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • blisters in the skin
  • blood in the urine
  • cloudy urine
  • decrease in how much or how often you urinate
  • difficulty with swallowing
  • dizziness
  • fainting or lightheadedness
  • fast heartbeat
  • flushing or redness of the skin
  • hives or welts, skin rash
  • itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea
  • sores on the skin
  • stomach pain
  • swelling of the hands, ankles, feet, or lower legs
  • unusual tiredness or weakness
  • unusually warm skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking pegfilgrastim:

Symptoms of overdose
  • Bone pain
  • chest pain
  • difficult or labored breathing
  • eye pain
  • general feeling of illness
  • headache

Some side effects of pegfilgrastim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Incidence not known
  • Body produces substance that can bind to drug making it less effective or cause side effects

For Healthcare Professionals

Applies to pegfilgrastim: subcutaneous solution


Uncommon (0.1% to 1%): Capillary leak syndrome[Ref]


Uncommon (0.1% to 1%): Acute febrile dermatosis (Sweet's syndrome), cutaneous vasculitis[Ref]


Very common (10% or more): Nausea[Ref]


Common (1% to 10%): Thrombocytopenia, leukocytosis
Uncommon (0.1% to 1%): Sickle cell crisis, splenomegaly, splenic rupture[Ref]


Uncommon (0.1% to 1%): Hypersensitivity reactions, anaphylaxis[Ref]


Common (1% to 10%): Injection site pain, noncardiac chest pain
Uncommon (0.1% to 1%): Injection site erythema[Ref]


Common (1% to 10%): Transient elevations in aspartate aminotransferase (AST) or alanine aminotransferase (ALT)[Ref]


Common (1% to 10%): Elevated uric acid
Uncommon (0.1% to 1%): Elevated lactate dehydrogenase, elevated alkaline phosphatase (ALP)[Ref]


Very common (10% or more): Bone pain (26%)
Common (1% to 10%): Myalgia, arthralgia, pain in extremity, back pain, musculoskeletal pain, neck pain[Ref]

Nervous system

Very common (10% or more): Headache[Ref]


Uncommon (0.1% to 1%): Acute respiratory distress syndrome, interstitial pneumonia, pulmonary edema, pulmonary infiltrates, pulmonary fibrosis[Ref]


Uncommon (0.1% to 1%): Glomerulonephritis[Ref]


1. "Product Information. Neulasta (pegfilgrastim)." Amgen, Thousand Oaks, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Some side effects of pegfilgrastim may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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