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Paxipam Side Effects

Generic Name: halazepam

Note: This document contains side effect information about halazepam. Some of the dosage forms listed on this page may not apply to the brand name Paxipam.

Applies to halazepam: oral tablet

Nervous system

Nervous system side effects have been common and have included drowsiness, sedation, somnolence, confusion, poor memory, dizziness, ataxia, and decreased motor coordination (particularly in elderly patients). Paradoxical excitement and behavioral disinhibition have also been observed by some clinicians.[Ref]

Gastrointestinal

Gastrointestinal side effects including nausea and dry mouth have been reported.[Ref]

Other

Other side effects have included withdrawal symptoms after either abrupt cessation or fast tapering of benzodiazepines and tolerance to the pharmacologic effects of other benzodiazepines has been reported . However, withdrawal symptoms have not been specifically reported for halazepam (the active ingredient contained in Paxipam) [Ref]

Withdrawal symptoms may include agitation, restlessness, anxiety, depression, insomnia, tremor, abdominal discomfort, blurred vision, vomiting, sweating, and seizures.[Ref]

Respiratory

Respiratory side effects including dose-dependent respiratory depression have been associated with use of other benzodiazepines but has not been specifically reported for halazepam (the active ingredient contained in Paxipam) [Ref]

References

1. Gagnon MA, Langlois Y, Boghen DR, Verdy M "Effects of halazepam and diazepam on the motor coordination of geriatric subjects." Eur J Clin Pharmacol 11 (1977): 443-8

2. Fann WE, Pitts WM, Wheless JC "Pharmacology, efficacy, and adverse effects of halazepam, a new benzodiazepine." Pharmacotherapy 2 (1982): 72-9

3. Fann WE, Sullivan JL, 3d Miller RD "Halazepam in anxious outpatients: a controlled study." Curr Ther Res Clin Exp 16 (1974): 1281-6

4. Mendels J, Wasserman TW, Michals TJ, Fine EW "Halazepam in the management of acute alcohol withdrawal syndrome." J Clin Psychiatry 46 (1985): 172-4

5. Aden GC, O'Hair DE "Effectiveness of bedtime dosing of benzodiazepines: a placebo- controlled comparison of halazepam and clorazepate." Clin Ther 3 (1980): 209-18

6. Pierce MW, Shu VS, Groves LJ "Safety of estazolam. The United States clinical experience." Am J Med 88 (1990): s12-7

7. "Product Information. ProSom (estazolam)." Abbott Pharmaceutical, Abbott Park, IL.

8. Skatrud JB, Badr S, Begle RL, Juan D "Ventilatory response to single, high dose estazolam in healthy humans." J Clin Pharmacol 30 (1990): 543-8

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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