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Palbociclib Side Effects

In Summary

Commonly reported side effects of palbociclib include: decreased neutrophils. Other side effects include: infection and pulmonary embolism. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to palbociclib: capsule oral, oral capsule

As well as its needed effects, palbociclib may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking palbociclib, check with your doctor immediately:

More common:
  • Black, tarry stools
  • body aches or pain
  • chills
  • cough
  • ear congestion
  • fever
  • headache
  • loss of voice
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • sneezing
  • sore throat
  • stuffy or runny nose
  • swelling or inflammation of the mouth
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common:
  • Anxiety
  • bloody nose
  • chest pain
  • dizziness or lightheadedness
  • fainting
  • fast heartbeat
  • hoarseness
  • sudden shortness of breath or troubled breathing

Minor Side Effects

Some palbociclib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Diarrhea
  • hair loss or thinning of the hair
  • lack or loss of strength
  • nausea
  • vomiting
Less common:
  • Burning, numbness, tingling, or painful sensation
  • decreased appetite
  • unsteadiness or awkwardness
  • weakness in the arms, legs, or feet

For Healthcare Professionals

Applies to palbociclib: oral capsule


Very common (10% or more): Decreased white blood cells (up to 95%), decreased neutrophils (up to 94%), decreased hemoglobin (up to 83%), decreased lymphocytes (up to 81%), neutropenia (up to 75%), decreased platelets (up to 61%), leukopenia (up to 43%), anemia (up to 35%), thrombocytopenia (up to 17%)
Frequency not reported: Febrile neutropenia[Ref]


Very common (10% or more): Upper respiratory infection (up to 31%), epistaxis (up to 11%)
Common (1% to 10%): Pulmonary embolism[Ref]


Very common (10% or more): Infections (up to 55%), fatigue (up to 41%), asthenia (up to 13%)[Ref]


Most common adverse reactions (10% or greater incidence): neutropenia, leukopenia, fatigue, anemia, infections, nausea, stomatitis, alopecia, diarrhea, thrombocytopenia, decreased appetite, vomiting, asthenia, peripheral neuropathy, and epistaxis.[Ref]


Very common (10% or more): Stomatitis (up to 25%), nausea (up to 25%), diarrhea (up to 25%), vomiting (up to 15%)[Ref]


Very common (10% or more): Alopecia (up to 22%)[Ref]


Very common (10% or more): Decreased appetite (up to 16%)[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (up to 13%)[Ref]


1. "Product Information. Ibrance (palbociclib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

It is possible that some side effects of palbociclib may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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