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Palbociclib Side Effects

In Summary

Commonly reported side effects of palbociclib include: decreased neutrophils. Other side effects include: infection and pulmonary embolism. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to palbociclib: capsule oral, oral capsule

Along with its needed effects, palbociclib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking palbociclib:

More Common

  • Black, tarry stools
  • body aches or pain
  • chills
  • cough
  • ear congestion
  • fever
  • headache
  • loss of voice
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • sneezing
  • sore throat
  • stuffy or runny nose
  • swelling or inflammation of the mouth
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less Common

Some side effects of palbociclib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

  • Burning, numbness, tingling, or painful sensation
  • decreased appetite
  • unsteadiness or awkwardness
  • weakness in the arms, legs, or feet

For Healthcare Professionals

Applies to palbociclib: oral capsule

Hematologic

Very common (10% or more): Decreased white blood cells (up to 95%), decreased neutrophils (up to 94%), decreased hemoglobin (up to 83%), decreased lymphocytes (up to 81%), neutropenia (up to 75%), decreased platelets (up to 61%), leukopenia (up to 43%), anemia (up to 35%), thrombocytopenia (up to 17%)

Frequency not reported: Febrile neutropenia[Ref]

Respiratory

Very common (10% or more): Upper respiratory infection (up to 31%), epistaxis (up to 11%)

Common (1% to 10%): Pulmonary embolism[Ref]

Other

Very common (10% or more): Infections (up to 55%), fatigue (up to 41%), asthenia (up to 13%)[Ref]

General

Most common adverse reactions (10% or greater incidence): neutropenia, leukopenia, fatigue, anemia, infections, nausea, stomatitis, alopecia, diarrhea, thrombocytopenia, decreased appetite, vomiting, asthenia, peripheral neuropathy, and epistaxis.[Ref]

Gastrointestinal

Very common (10% or more): Stomatitis (up to 25%), nausea (up to 25%), diarrhea (up to 25%), vomiting (up to 15%)[Ref]

Dermatologic

Very common (10% or more): Alopecia (up to 22%)[Ref]

Metabolic

Very common (10% or more): Decreased appetite (up to 16%)[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (up to 13%)[Ref]

References

1. "Product Information. Ibrance (palbociclib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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