Skip to main content

Palbociclib Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Dec 13, 2021.


Commonly reported side effects of palbociclib include: decreased neutrophils. Other side effects include: infection and pulmonary embolism. Continue reading for a comprehensive list of adverse effects.

Applies to palbociclib: oral capsules.

Side effects include:

Adverse effects reported in ≥10% of patients: Neutropenia, infection, leukopenia, fatigue, nausea, stomatitis, anemia, alopecia, diarrhea, thrombocytopenia, rash, vomiting, decreased appetite, asthenia, pyrexia.

For Healthcare Professionals

Applies to palbociclib: oral capsule, oral tablet.


Very common (10% or more): Decreased white blood cells (95%), decreased neutrophils (94%), decreased hemoglobin (83%), decreased lymphocytes (81%), neutropenia (80%), decreased platelets (61%), leukopenia (39%), anemia (24%), thrombocytopenia (16%)

Frequency not reported: Febrile neutropenia[Ref]


Very common (10% or more): Upper respiratory infection (up to 31%), epistaxis (up to 11%)

Common (1% to 10%): Pulmonary embolism, interstitial lung disease, pneumonitis[Ref]


Very common (10% or more): Fatigue (37%), asthenia (17%), pyrexia (12%)[Ref]


Most common adverse reactions (10% or greater incidence): Neutropenia, leukopenia, fatigue, anemia, infections, nausea, stomatitis, alopecia, diarrhea, thrombocytopenia, decreased appetite, vomiting, asthenia, peripheral neuropathy, and epistaxis.[Ref]


Very common (10% or more): Nausea (35%), stomatitis (30%), diarrhea (26%), vomiting (16%)[Ref]


Very common (10% or more): Alopecia (33%), rash (18%), dry skin (12%)[Ref]


Very common (10% or more): Decreased appetite (16%)[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (13%), dysgeusia (10%)[Ref]


Very common (10% or more): Infections (e.g., nasopharyngitis, upper respiratory tract infection, urinary tract infection, oral herpes, sinusitis, rhinitis, bronchitis, influenza, pneumonia, gastroenteritis, conjunctivitis, herpes zoster, pharyngitis, cellulitis, cystitis, lower respiratory tract infection, tooth infection, gingivitis, skin infection, gastroenteritis viral, respiratory tract infection, respiratory tract infection viral, folliculitis) (60%)[Ref]

Frequently asked questions


1. "Product Information. Ibrance (palbociclib)." Pfizer U.S. Pharmaceuticals Group (2015):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.