Palbociclib Side Effects
Medically reviewed by Drugs.com. Last updated on Jan 7, 2021.
Commonly reported side effects of palbociclib include: decreased neutrophils. Other side effects include: infection and pulmonary embolism. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to palbociclib: capsule oral, oral capsule, oral tablet
Side effects requiring immediate medical attention
Along with its needed effects, palbociclib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking palbociclib:
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- chest pain
- difficulty breathing
- loss of voice
- lower back or side pain
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swelling or inflammation of the mouth
- swollen glands
- troubled breathing with exertion
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
Incidence not known
- General feeling of discomfort or illness
- thickening of bronchial secretions
Side effects not requiring immediate medical attention
Some side effects of palbociclib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Blurred vision
- decreased appetite
- dry skin
- hair loss or thinning of the hair
- increased tearing
- lack or loss of strength
- loss of or change in taste
- skin rash
- Dry eye
For Healthcare Professionals
Applies to palbociclib: oral capsule, oral tablet
Very common (10% or more): Decreased white blood cells (95%), decreased neutrophils (94%), decreased hemoglobin (83%), decreased lymphocytes (81%), neutropenia (80%), decreased platelets (61%), leukopenia (39%), anemia (24%), thrombocytopenia (16%)
Very common (10% or more): Upper respiratory infection (up to 31%), epistaxis (up to 11%)
Very common (10% or more): Fatigue (37%), asthenia (17%), pyrexia (12%)[Ref]
Most common adverse reactions (10% or greater incidence): Neutropenia, leukopenia, fatigue, anemia, infections, nausea, stomatitis, alopecia, diarrhea, thrombocytopenia, decreased appetite, vomiting, asthenia, peripheral neuropathy, and epistaxis.[Ref]
Very common (10% or more): Nausea (35%), stomatitis (30%), diarrhea (26%), vomiting (16%)[Ref]
Very common (10% or more): Alopecia (33%), rash (18%), dry skin (12%)[Ref]
Very common (10% or more): Decreased appetite (16%)[Ref]
Very common (10% or more): Peripheral neuropathy (13%), dysgeusia (10%)[Ref]
Very common (10% or more): Infections (e.g., nasopharyngitis, upper respiratory tract infection, urinary tract infection, oral herpes, sinusitis, rhinitis, bronchitis, influenza, pneumonia, gastroenteritis, conjunctivitis, herpes zoster, pharyngitis, cellulitis, cystitis, lower respiratory tract infection, tooth infection, gingivitis, skin infection, gastroenteritis viral, respiratory tract infection, respiratory tract infection viral, folliculitis) (60%)[Ref]
Frequently asked questions
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More about palbociclib
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- En Español
- 72 Reviews
- Drug class: CDK 4/6 inhibitors
- Other brands
Related treatment guides
1. "Product Information. Ibrance (palbociclib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Some side effects may not be reported. You may report them to the FDA.