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Palbociclib Side Effects

For the Consumer

Applies to palbociclib: capsule oral, oral capsule

Along with its needed effects, palbociclib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking palbociclib:

More common
  • Black, tarry stools
  • body aches or pain
  • chills
  • cough
  • ear congestion
  • fever
  • headache
  • loss of voice
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • sneezing
  • sore throat
  • stuffy or runny nose
  • swelling or inflammation of the mouth
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Anxiety
  • bloody nose
  • chest pain
  • dizziness or lightheadedness
  • fainting
  • fast heartbeat
  • hoarseness
  • sudden shortness of breath or troubled breathing

Some side effects of palbociclib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea
  • hair loss or thinning of the hair
  • lack or loss of strength
  • nausea
  • vomiting
Less common
  • Burning, numbness, tingling, or painful sensation
  • decreased appetite
  • unsteadiness or awkwardness
  • weakness in the arms, legs, or feet

For Healthcare Professionals

Applies to palbociclib: oral capsule


Very common (10% or more): Decreased white blood cells (up to 95%), decreased neutrophils (up to 94%), decreased hemoglobin (up to 83%), decreased lymphocytes (up to 81%), neutropenia (up to 75%), decreased platelets (up to 61%), leukopenia (up to 43%), anemia (up to 35%), thrombocytopenia (up to 17%)
Frequency not reported: Febrile neutropenia[Ref]


Very common (10% or more): Upper respiratory infection (up to 31%), epistaxis (up to 11%)
Common (1% to 10%): Pulmonary embolism[Ref]


Very common (10% or more): Infections (up to 55%), fatigue (up to 41%), asthenia (up to 13%)[Ref]


Most common adverse reactions (10% or greater incidence): neutropenia, leukopenia, fatigue, anemia, infections, nausea, stomatitis, alopecia, diarrhea, thrombocytopenia, decreased appetite, vomiting, asthenia, peripheral neuropathy, and epistaxis.[Ref]


Very common (10% or more): Stomatitis (up to 25%), nausea (up to 25%), diarrhea (up to 25%), vomiting (up to 15%)[Ref]


Very common (10% or more): Alopecia (up to 22%)[Ref]


Very common (10% or more): Decreased appetite (up to 16%)[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (up to 13%)[Ref]


1. "Product Information. Ibrance (palbociclib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

Some side effects of palbociclib may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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