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Ongentys Side Effects

Generic name: opicapone

Medically reviewed by Drugs.com. Last updated on May 25, 2020.

Note: This document contains side effect information about opicapone. Some of the dosage forms listed on this page may not apply to the brand name Ongentys.

For the Consumer

Applies to opicapone: oral capsule

Warning

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • confusion, hallucinations (hearing or seeing something that is not there);

  • aggression, agitation, unusual thoughts or behavior;

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); or

  • worsening tremors, stiffness, or muscle spasms.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

Common side effects may include:

When you stop taking opicapone (the active ingredient contained in Ongentys) watch for withdrawal symptoms such as: stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, or feeling like you might pass out.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to opicapone: oral capsule

General

The most commonly reported adverse reaction was dyskinesia.[Ref]

Nervous system

Very common (10% or more): Dyskinesia (17.7%)

Common (1% to 10%): Dizziness, headache, somnolence

Uncommon (0.1% to 1%): Dysgeusia, hyperkinesia, syncope[Ref]

Psychiatric

Common (1% to 10%): Abnormal dreams, hallucination, visual hallucination, insomnia

Uncommon (0.1% to 1%): Anxiety, depression, auditory hallucination, nightmares, sleep disorder[Ref]

Cardiovascular

Common (1% to 10%): Orthostatic hypotension

Uncommon (0.1% to 1%): Palpitations, hypertension, hypotension[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, dry mouth, vomiting

Uncommon (0.1% to 1%): Abdominal distention, abdominal pain, upper abdominal pain, dyspepsia[Ref]

Metabolic

Uncommon (0.1% to 1%): Decreased appetite, hypertriglyceridemia, decreased weight[Ref]

Respiratory

Uncommon (0.1% to 1%): Dyspnea[Ref]

Genitourinary

Uncommon (0.1% to 1%): Chromaturia, nocturia[Ref]

Musculoskeletal

Common (1% to 10%): Muscle spasms

Uncommon (0.1% to 1%): Muscle twitching, musculoskeletal stiffness, myalgia, extremity pain[Ref]

Ocular

Uncommon (0.1% to 1%): Dry eye

Other

Common (1% to 10%): Blood creatine phosphokinase increased

Uncommon (0.1% to 1%): Ear congestion[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Ongentys (opicapone)." Neurocrine Biosciences, Inc., San Diego, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.