Skip to main content

Ongentys Side Effects

Generic name: opicapone

Medically reviewed by Philip Thornton, DipPharm. Last updated on May 18, 2022.

Note: This document contains side effect information about opicapone. Some of the dosage forms listed on this page may not apply to the brand name Ongentys.

For the Consumer

Applies to opicapone: oral capsule

Side effects requiring immediate medical attention

Along with its needed effects, opicapone (the active ingredient contained in Ongentys) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking opicapone:

More common

  • Twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

Less common

  • Blurred vision
  • confusion
  • dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
  • headache
  • nervousness
  • pounding in the ears
  • seeing, hearing, or feeling things that are not there
  • slow or fast heartbeat
  • sweating
  • unusual tiredness or weakness

Side effects not requiring immediate medical attention

Some side effects of opicapone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to opicapone: oral capsule

General

The most commonly reported adverse reaction was dyskinesia.[Ref]

Nervous system

Very common (10% or more): Dyskinesia (17.7%)

Common (1% to 10%): Dizziness, headache, somnolence

Uncommon (0.1% to 1%): Dysgeusia, hyperkinesia, syncope

Postmarketing reports: Balance disorder, hyperkinesia tremor[Ref]

Psychiatric

Common (1% to 10%): Abnormal dreams, hallucination, visual hallucination, insomnia

Uncommon (0.1% to 1%): Anxiety, depression, auditory hallucination, nightmares, sleep disorder

Postmarketing reports: Agitation, psychotic disorder, confusional state[Ref]

Cardiovascular

Common (1% to 10%): Orthostatic hypotension

Uncommon (0.1% to 1%): Palpitations, hypertension, hypotension[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, dry mouth, vomiting

Uncommon (0.1% to 1%): Abdominal distention, abdominal pain, upper abdominal pain, dyspepsia

Postmarketing reports: Diarrhea, nausea[Ref]

Metabolic

Uncommon (0.1% to 1%): Decreased appetite, hypertriglyceridemia, decreased weight[Ref]

Respiratory

Uncommon (0.1% to 1%): Dyspnea[Ref]

Genitourinary

Uncommon (0.1% to 1%): Chromaturia, nocturia[Ref]

Musculoskeletal

Common (1% to 10%): Muscle spasms

Uncommon (0.1% to 1%): Muscle twitching, musculoskeletal stiffness, myalgia, extremity pain[Ref]

Ocular

Uncommon (0.1% to 1%): Dry eye

Other

Common (1% to 10%): Blood creatine phosphokinase increased

Uncommon (0.1% to 1%): Ear congestion

Postmarketing reports: Fatigue, malaise[Ref]

Frequently asked questions

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Ongentys (opicapone)." Neurocrine Biosciences, Inc. (2020):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.