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Octreotide Side Effects

In Summary

Commonly reported side effects of octreotide include: hyperglycemia, cardiac conduction disturbance, and gallbladder sludge. Other side effects include: cardiac arrhythmia, and hypoglycemia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to octreotide: powder for solution, powder for suspension, solution

As well as its needed effects, octreotide may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking octreotide, check with your doctor or nurse immediately:

More common:
  • Abdominal or stomach pain
  • blurred vision
  • constipation
  • depressed mood
  • dizziness
  • dry mouth
  • dry skin and hair
  • fainting
  • fast, slow, or irregular heartbeat
  • feeling cold
  • flushed, dry skin
  • fruit-like breath odor
  • hair loss
  • hoarseness or husky voice
  • increased hunger
  • increased thirst
  • increased urination
  • muscle cramps and stiffness
  • nausea
  • severe stomach pain with nausea and vomiting
  • sweating
  • troubled breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting
  • weight gain
Less common or rare:
  • Abdominal or stomach bloating
  • anxious feeling
  • behavior change similar to drunkenness
  • changes in menstrual periods
  • cold sweats
  • confusion
  • convulsions (seizures)
  • cool, pale skin
  • decreased sexual ability in males
  • difficulty with concentrating
  • drowsiness
  • headache
  • loss of appetite
  • muscle cramps and stiffness
  • nightmares
  • restless sleep
  • shakiness
  • slurred speech
  • swelling of the front part of the neck
  • tiredness
  • troubled breathing (rapid and deep)
  • unconsciousness
  • unusual thirst
Incidence not known:
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • chills
  • darkened urine
  • fever
  • indigestion
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pinpoint red spots on the skin
  • severe constipation
  • unusual bleeding or bruising
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking octreotide, get emergency help immediately:

Symptoms of overdose:
  • Abdominal or stomach discomfort
  • decreased appetite
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, shallow breathing
  • feeling of warmth
  • general feeling of discomfort
  • light-colored stools
  • muscle pain or cramping
  • no blood pressure or pulse
  • redness of the face, neck, arms, and occasionally, upper chest
  • shortness of breath
  • sleepiness
  • stopping of heart
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • upper right abdominal or stomach pain
  • weakness
  • weight loss

Severity: Minor

Some octreotide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Pain, redness, stinging, swelling, tingling, or burning sensation at the injection site
  • passing of gas
Less common or rare:
  • Backache
  • bladder pain
  • cloudy urine
  • cough
  • difficult, burning, or painful urination
  • disturbed color perception
  • double vision
  • frequent urge to urinate
  • frequent urination usually with very small amounts of urine
  • general feeling of discomfort or illness
  • halos around lights
  • itching skin
  • joint pain
  • lack of appetite
  • loss of vision
  • lower back or side pain
  • muscle aches and pains
  • night blindness
  • overbright appearance of lights
  • runny nose
  • shivering
  • sore throat
  • stools that float, are foul smelling, and fatty in appearance
  • trouble concentrating
  • trouble sleeping
  • tunnel vision

For Healthcare Professionals

Applies to octreotide: injectable solution, intramuscular powder for injection extended release

General

The most common adverse events were gastrointestinal disorders, nervous system disorders, hepatobiliary disorders, and metabolism and nutritional disorders.[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (57.9%), abdominal pain (43.9%), nausea (29.8%), flatulence (25.3%), constipation (18.8%), abdominal pain upper (10.5%), abdominal discomfort, loose stools
Common (1% to 10%): Fat malabsorption, vomiting, dyspepsia, steatorrhea, discoloration of feces, tenesmus, abdominal distension
Uncommon (0.1% to 1%): GI bleeding, hemorrhoids, appendicitis, gastric/peptic ulcer
Frequency not reported: Pancreatitis, vomiting, abnormal stools, severe epigastric pain, abdominal tenderness and guarding
Postmarketing reports: Intestinal obstruction[Ref]

Cardiovascular

Very common (10% or more): Bradycardia (25%), hypertension (12.6%), conduction abnormalities (10%)
Common (1% to 10%): Arrhythmias, flushing
Uncommon (0.1% to 1%): Chest pain, shortness of breath, thrombophlebitis, ischemia, congestive heart failure, palpitations, orthostatic blood pressure decrease, tachycardia[Ref]

Hepatic

Very common (10% or more): Gallstones (27%), sludge without stones (24%), cholelithiasis (38.2%), biliary duct dilatation (12%)
Common (1% to 10%): Transaminase increased
Uncommon (0.1% to 1%): Hepatitis, jaundice, increase in liver enzymes, gallbladder polyp
Rare (less than 0.1%): Acute pancreatitis
Frequency not reported: Acute cholecystitis, ascending cholangitis, biliary obstruction, cholestatic hepatitis, pancreatitis[Ref]

Nervous system

Very common (10% or more): Headache (30%), dizziness (20%)
Uncommon (0.1% to 1%): Syncope, tremor, seizure, vertigo, Bell's palsy, pituitary apoplexy, amnesia, neuritis[Ref]

Metabolic

Very common (10% or more): Hyperglycemia (16%)
Common (1% to 10%): Hypoglycemia, edema, anorexia
Uncommon (0.1% to 1%): Weight loss, dehydration
Frequency not reported: Depressed vitamin B12 levels, abnormal Schilling's test[Ref]

Hematologic

Very common (10% or more): Anemia (15.3%)
Uncommon (0.1% to 1%): Iron deficiency
Postmarketing reports: Thrombocytopenia[Ref]

Endocrine

Very common (10% or more): Biochemical hypothyroidism (12%)
Common (1% to 10%): Goiter, thyroid dysfunction (e.g. decreased TSH, decreased Total T4, and decreased Free T4)
Uncommon (0.1% to 1%): Galactorrhea, hypoadrenalism, diabetes insipidus[Ref]

Local

Very common (10% or more): Injection site pain (13.8%), injection site reactions
Common (1% to 10%): Injection site hematoma[Ref]

Dermatologic

Very common (10% or more): Alopecia (13.2%)
Common (1% to 10%): Pruritus, bruise, rash
Uncommon (0.1% to 1%): Cellulitis, petechiae, urticaria, basal cell carcinoma[Ref]

Musculoskeletal

Common (1% to 10%): Joint pain, backache
Uncommon (0.1% to 1%): Arthritis, joint effusion, muscle pain, Raynaud's phenomenon[Ref]

Psychiatric

Common (1% to 10%): Depression
Uncommon (0.1% to 1%): Anxiety, paranoia, libido decrease[Ref]

Other

Very common (10% or more): Fatigue (31.8%), generalized pain (15%)
Common (1% to 10%): Weakness
Uncommon (0.1% to 1%): Hearing loss, otitis[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infection (18.2%), sinusitis (12%)
Common (1% to 10%): Cold symptoms, flu symptoms, epistaxis
Uncommon (0.1% to 1%): Pneumonia, pulmonary nodule, status asthmaticus[Ref]

Renal

Uncommon (0.1% to 1%): Increased creatinine kinase[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Allergic reaction
Frequency not reported: Anaphylactic reaction[Ref]

Immunologic

Very common (10% or more): Antibodies to octreotide (25%)

Ocular

Common (1% to 10%): Blurred vision, visual disturbance
Uncommon (0.1% to 1%): Increased intraocular pressure[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection, pollakiuria
Uncommon (0.1% to 1%): Gynecomastia, amenorrhea, polymenorrhea, oligomenorrhea, vaginitis, nephrolithiasis, hematuria[Ref]

References

1. "Product Information. Octreotide Acetate (octreotide)." Teva SICOR Pharmaceuticals Inc, Irvine, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

4. "Product Information. Sandostatin (octreotide)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.

5. "Product Information. SandoSTATIN LAR Depot (octreotide)." Novartis Consumer Health, Parsippany, NJ.

It is possible that some side effects of octreotide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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