Octreotide use while Breastfeeding
Drugs containing Octreotide: Sandostatin, Sandostatin LAR Depot
Medically reviewed by Drugs.com. Last updated on Feb 21, 2019.
Octreotide Levels and Effects while Breastfeeding
Summary of Use during Lactation
The excretion of octreotide into breastmilk has not been studied. However, because it has a high molecular weight of 1019 daltons it is likely to be poorly excreted into breastmilk. It is poorly absorbed orally and has been safely administered directly to infants by injection, so it is unlikely to adversely affect the breastfed infant. One breastfed infant experienced no adverse effects during maternal use of octreotide. Until more data are available, octreotide should be used in nursing mothers with careful infant monitoring, especially if the infant is under 2 months of age.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
One mother was treated for acromegaly during pregnancy and postpartum with octreotide (dose not stated). She breastfed (extent not stated) her infant for 4 months with no apparent problems noted in the infant.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
1. van der Steen I, van Albada ME, Mohnike K et al. A multicenter experience with long-acting somatostatin analogues in patients with congenital hyperinsulinism. Horm Res Paediatr. 2018;89:82-9. PMID: 29241206
2. Colao A, Merola B, Ferone D, Lombardi G. Acromegaly. J Clin Endocrinol Metab. 1997;82:2777-81. PMID: 9284694
CAS Registry Number
Antineoplastic Agents, Hormonal
LactMed Record Number
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