Skip to Content

Octreotide use while Breastfeeding

Drugs containing Octreotide: Sandostatin, Sandostatin LAR Depot

Medically reviewed by Last updated on Feb 21, 2019.

Octreotide Levels and Effects while Breastfeeding

Summary of Use during Lactation

The excretion of octreotide into breastmilk has not been studied. However, because it has a high molecular weight of 1019 daltons it is likely to be poorly excreted into breastmilk. It is poorly absorbed orally and has been safely administered directly to infants by injection, so it is unlikely to adversely affect the breastfed infant.[1] One breastfed infant experienced no adverse effects during maternal use of octreotide. Until more data are available, octreotide should be used in nursing mothers with careful infant monitoring, especially if the infant is under 2 months of age.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

One mother was treated for acromegaly during pregnancy and postpartum with octreotide (dose not stated). She breastfed (extent not stated) her infant for 4 months with no apparent problems noted in the infant.[2]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


1. van der Steen I, van Albada ME, Mohnike K et al. A multicenter experience with long-acting somatostatin analogues in patients with congenital hyperinsulinism. Horm Res Paediatr. 2018;89:82-9. PMID: 29241206

2. Colao A, Merola B, Ferone D, Lombardi G. Acromegaly. J Clin Endocrinol Metab. 1997;82:2777-81. PMID: 9284694

Octreotide Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Antineoplastic Agents, Hormonal

Gastrointestinal Agents

Somatostatin Analogs

Administrative Information

LactMed Record Number



Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.