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Somatuline Depot

Generic Name: lanreotide (lan REE oh tide)
Brand Names: Somatuline Depot

Medically reviewed on Mar 1, 2018

What is Somatuline Depot?

Somatuline Depot (lanreotide) is a man-made protein similar to a hormone in the body called somatostatin. Lanreotide lowers many substances in the body such as insulin and glucagon (involved in regulating blood sugar), growth hormone, and chemicals that affect digestion.

Somatuline Depot is used in adults to treat:

  • acromegaly that cannot be treated with surgery or radiation;

  • carcinoid syndrome; or

  • a certain type of pancreatic or digestive tract tumor that may spread to other parts of the body.

Somatuline Depot is sometimes given after other treatments have failed.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Somatuline Depot if you are allergic to lanreotide.

To make sure Somatuline Depot is safe for you, tell your doctor if you have ever had:

  • gallbladder disease;

  • diabetes (your diabetes medicine may need to be adjusted);

  • liver or kidney disease;

  • heart disease; or

  • a thyroid disorder.

It is not known whether Somatuline Depot will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using lanreotide and for at least 6 months after your last dose.

How is Somatuline Depot given?

Somatuline Depot is injected under the skin.

You will receive a Somatuline Depot injection every 4 weeks in your healthcare provider's office.

Your healthcare provider may change your dose or the length of time between your injections. Your healthcare provider will tell you how long you need to receive Somatuline Depot.

Somatuline Depot is injected deep under the skin of the upper outer area of your buttock. Your injection site should change (alternate) between your right and left buttock from one injection to the next.

During your treatment with Somatuline Depot for acromegaly, your healthcare provider may do certain blood tests to see if this medicine is working.

Call your doctor if your symptoms do not improve, or if they get worse.

Somatuline Depot dosing information

Usual Adult Dose for Acromegaly:

Initial dose: 90 mg, by deep subcutaneous injection, every 4 weeks for 3 months

-The goal of treatment is to reduce growth hormone (GH) and insulin-like growth factor (IGF-1) levels to normal.
-Adjust dose after initial 3 months.
-No dose adjustment is required for elderly patients.

Use: Long-term treatment of acromegalic patients who have had an inadequate response to surgery and/or radiotherapy, or for whom surgery and/or radiotherapy is not an option.

Usual Adult Dose for Neuroendocrine Carcinoma:

120 mg, by deep subcutaneous (SC) injection, every 4 weeks

Comments: No dose adjustment is required for elderly patients.

Use: Treatment of patients with unresectable, well or moderately-differentiated, locally advanced, or metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) to improve progression-free survival.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Somatuline Depot injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Somatuline Depot?

Lanreotide can make it harder for your body to absorb other medicines you take by mouth. Ask your doctor about the best schedule for taking all of your needed medicines.

Somatuline Depot side effects

Get emergency medical help if you have signs of an allergic reaction to Somatuline Depot: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • slow heartbeats;

  • low blood sugar - headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky;

  • high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor, headache, blurred vision;

  • increased blood pressure - severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed; or

  • signs of a gallbladder problem - sudden severe pain in your upper stomach spreading to your back or shoulder (may occur after meals or at night), pain when breathing, nausea, vomiting, loss of appetite, fever, chills, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common Somatuline Depot side effects may include:

  • nausea, vomiting, stomach pain;

  • diarrhea, gas;

  • muscle or joint pain;

  • headache, dizziness; or

  • pain, itching, or a hard lump where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Somatuline Depot?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with lanreotide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this Somatuline Depot only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.