Somatuline Depot Side Effects

Generic name: lanreotide

Medically reviewed by Drugs.com. Last updated on Jul 15, 2024.

Note: This document provides detailed information about Somatuline Depot Side Effects associated with lanreotide. Some dosage forms listed on this page may not apply specifically to the brand name Somatuline Depot.

Applies to lanreotide: subcutaneous solution.

Serious side effects of Somatuline Depot

Along with its needed effects, lanreotide (the active ingredient contained in Somatuline Depot) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lanreotide:

Other side effects of Somatuline Depot

Some side effects of lanreotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to lanreotide: subcutaneous solution.

General adverse events

The most common adverse events were gastrointestinal disorders, cholelithiasis, and injection site reactions.^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 65%), abdominal pain (34%), vomiting (19%), flatulence (14%), nausea (11%), loose stools
• Common (1% to 10%): Constipation, flatulence, abdominal distension, abdominal discomfort, dyspepsia
• Uncommon (0.1% to 1%): Pancreatitis, feces discolored
• Frequency not reported: Steatorrhea^[Ref]

In one of the studies, diarrhea, abdominal pain, and flatulence increased as the dose increased.^[Ref]

Hepatic

• Very common (10% or more): Cholelithiasis (27%), bladder sludge (20%), new cholelithiasis
• Common (1% to 10%): ALT increased, AST abnormal, ALT abnormal, blood bilirubin increased, biliary dilatation
• Uncommon (0.1% to 1%): AST increased, blood alkaline phosphatase increased, blood bilirubin abnormal
• Frequency not reported: Cholecystitis
• Postmarketing reports: Steatorrhea, pancreatitis^[Ref]

Cardiovascular

• Very common (10% or more): Bradycardia (18%), hypertension (14%)
• Common (1% to 10%): Sinus bradycardia
• Uncommon (0.1% to 1%): Other cardiac adverse drug reactions^[Ref]

Local

• Very common (10% or more): Application site disorder (injection site mass/pain/reaction/inflammation/ nodule/pruritus, 30%)
• Postmarketing reports: Persisting induration, injection site abscess^[Ref]

Metabolic

• Very common (10% or more): Dysglycemia (hypoglycemia, hyperglycemia, diabetes, 14%), weight decrease (11%)
• Common (1% to 10%): Blood glucose increased, glycosylated hemoglobin increased
• Uncommon (0.1% to 1%): Blood sodium decreased, diabetes mellitus aggravated^[Ref]

Hematologic

• Very common (10% or more): Anemia (14%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (19%), arthralgia (11%)^[Ref]

Nervous system

• Very common (10% or more): Headache (16%)
• Common (1% to 10%): Dizziness
• Postmarketing reports: Dysautonomia^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea^[Ref]

Psychiatric

• Common (1% to 10%): Depression
• Uncommon (0.1% to 1%): Insomnia^[Ref]

Other

• Common (1% to 10%): Fatigue
• Uncommon (0.1% to 1%): Hot flush, asthenia
• Postmarketing reports: Malaise^[Ref]

Immunologic

• Common (1% to 10%): Anti-lanreotide (the active ingredient contained in Somatuline Depot) antibodies^[Ref]

Hypersensitivity

• Frequency not reported: Allergic reactions (including angioedema, anaphylaxis, and hypersensitivity)^[Ref]

Dermatologic

• Common (1% to 10%): Alopecia, hypotrichosis^[Ref]

Endocrine

• Rare (less than 0.1%): Clinical hypothyroidism
• Frequency not reported: Slight decreases in thyroid function^[Ref]

See also:

Further information

Somatuline Depot side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer