Somatuline Depot Side Effects

Generic name: lanreotide

Medically reviewed by Drugs.com. Last updated on Jul 15, 2024.

Note: This document provides detailed information about Somatuline Depot.

Applies to lanreotide: subcutaneous solution Side Effects associated with lanreotide. Some dosage forms listed on this page may not apply specifically to the brand name Somatuline Depot.

Applies to lanreotide: subcutaneous solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may increase your risk of having gallstones, which may lead to swelling of the gallbladder (cholecystitis), bile ducts (cholangitis), or pancreas (pancreatitis). Check with your doctor right away if you have severe stomach pain with nausea and vomiting, indigestion, fever, chills, pains in the stomach, side, or abdomen, possibly radiating to the back, fast heartbeat, dark urine, bloating, or yellow eyes or skin.

This medicine may cause your blood sugar levels to rise or fall. This medicine may cover up signs of hypoglycemia (low blood sugar), such as a change in your pulse rate. If you notice a change in the results of your blood sugar test or urine sugar test, check with your doctor.

This medicine may increase your risk for heart and blood vessel problems, including hypertension and a slow heartbeat. This may cause chest pain or discomfort, headaches, dizziness, or blurred vision. You might need to measure your blood pressure at home. If you think your blood pressure is too high or if your heartbeat is too slow, call your doctor right away.

This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

If you plan to have children, talk with your doctor before using this medicine. Some women using this medicine have become infertile (unable to have children).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Somatuline Depot

Along with its needed effects, lanreotide (the active ingredient contained in Somatuline Depot) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lanreotide:

Other side effects of Somatuline Depot

Some side effects of lanreotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to lanreotide: subcutaneous solution.

General adverse events

The most common adverse events were gastrointestinal disorders, cholelithiasis, and injection site reactions.^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 65%), abdominal pain (34%), vomiting (19%), flatulence (14%), nausea (11%), loose stools
• Common (1% to 10%): Constipation, flatulence, abdominal distension, abdominal discomfort, dyspepsia
• Uncommon (0.1% to 1%): Pancreatitis, feces discolored
• Frequency not reported: Steatorrhea^[Ref]

In one of the studies, diarrhea, abdominal pain, and flatulence increased as the dose increased.^[Ref]

Hepatic

• Very common (10% or more): Cholelithiasis (27%), bladder sludge (20%), new cholelithiasis
• Common (1% to 10%): ALT increased, AST abnormal, ALT abnormal, blood bilirubin increased, biliary dilatation
• Uncommon (0.1% to 1%): AST increased, blood alkaline phosphatase increased, blood bilirubin abnormal
• Frequency not reported: Cholecystitis
• Postmarketing reports: Steatorrhea, pancreatitis^[Ref]

Cardiovascular

• Very common (10% or more): Bradycardia (18%), hypertension (14%)
• Common (1% to 10%): Sinus bradycardia
• Uncommon (0.1% to 1%): Other cardiac adverse drug reactions^[Ref]

Local

• Very common (10% or more): Application site disorder (injection site mass/pain/reaction/inflammation/ nodule/pruritus, 30%)
• Postmarketing reports: Persisting induration, injection site abscess^[Ref]

Metabolic

• Very common (10% or more): Dysglycemia (hypoglycemia, hyperglycemia, diabetes, 14%), weight decrease (11%)
• Common (1% to 10%): Blood glucose increased, glycosylated hemoglobin increased
• Uncommon (0.1% to 1%): Blood sodium decreased, diabetes mellitus aggravated^[Ref]

Hematologic

• Very common (10% or more): Anemia (14%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (19%), arthralgia (11%)^[Ref]

Nervous system

• Very common (10% or more): Headache (16%)
• Common (1% to 10%): Dizziness
• Postmarketing reports: Dysautonomia^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea^[Ref]

Psychiatric

• Common (1% to 10%): Depression
• Uncommon (0.1% to 1%): Insomnia^[Ref]

Other

• Common (1% to 10%): Fatigue
• Uncommon (0.1% to 1%): Hot flush, asthenia
• Postmarketing reports: Malaise^[Ref]

Immunologic

• Common (1% to 10%): Anti-lanreotide (the active ingredient contained in Somatuline Depot) antibodies^[Ref]

Hypersensitivity

• Frequency not reported: Allergic reactions (including angioedema, anaphylaxis, and hypersensitivity)^[Ref]

Dermatologic

• Common (1% to 10%): Alopecia, hypotrichosis^[Ref]

Endocrine

• Rare (less than 0.1%): Clinical hypothyroidism
• Frequency not reported: Slight decreases in thyroid function^[Ref]

See also:

Further information

Somatuline Depot side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer