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Nonoxynol 9 topical Side Effects

Medically reviewed by Last updated on Mar 28, 2024.

Applies to nonoxynol 9 topical: vaginal film, vaginal gel, vaginal suppository. Other dosage forms:

Serious side effects of Nonoxynol 9 topical

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects of Nonoxynol 9 topical

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to nonoxynol 9 topical: vaginal cream with applicator, vaginal device, vaginal film, vaginal foam, vaginal foam with applicator, vaginal gel, vaginal gel with applicator, vaginal suppository.


Frequency not reported: Epithelial damage[Ref]


Frequency not reported: Increased risk of human immunodeficiency virus infection[Ref]


Frequency not reported: Application site reactions (irritation, pain, discomfort, burning sensation, itching, dryness, rash, and redness of the vulva, vagina or penis)[Ref]


Frequency not reported: Hypersensitivity[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.