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Nonoxynol-9 use while Breastfeeding

Medically reviewed by Last updated on Sep 26, 2023.

Drugs containing Nonoxynol-9: Advantage 24 Contraceptive, VCF Vaginal Contraceptive, Shur-Seal Gel, Encare, Koromex, Delfen Foam, Emko, Ramses Crystal Clear, Conceptrol, Ramses Personal, Show all 16 »Semicid Contraceptive Suppositories, Koromex Contraceptive, Koromex Crystal Clear Gel, Gynol II Jelly with Applicator, K-Y Plus Nonoxynol 9, Advantage-S

Nonoxynol-9 Levels and Effects while Breastfeeding

Summary of Use during Lactation

Nonoxynol-9 is a relatively nontoxic nonionic surfactant and only trivial amounts of the drug have been found in the milk of animals after vaginal administration.[1] Limited information indicates that breastfed infants of mothers using vaginal nonoxynol-9 experienced no adverse effects. Vaginal use of nonoxynol-9 is acceptable in nursing mothers.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In a study comparing various methods of contraception, the breastfed infants of women who used a nonoxynol-9-containing foam had no observable adverse effects.[2]

Effects on Lactation and Breastmilk

Compared with a combination contraceptive containing ethinyl estradiol 30 mcg and levonorgestrel 150 mcg, women who used either nonoxynol-9 foam or copper-T IUD had less inhibition of lactation than the combined oral contraceptive.[2]


Johnson W Jr. Final report on the safety assessment of octoxynol-1, octoxynol-3, octoxynol-5, octoxynol-6, octoxynol-7, octoxynol-8, octoxynol-9, octoxynol-10, octoxynol-11, octoxynol-12, octoxynol-13, octoxynol-16, octoxynol-20, octoxynol-25, octoxynol-30, octoxynol-33, octoxynol-40, octoxynol-70, octoxynol-9 carboxylic acid, octoxynol-20 carboxylic acid, potassium octoxynol-12 phosphate, sodium octoxynol-2 ethane sulfonate, sodium octoxynol-2 sulfate, sodium octoxynol-6 sulfate, and sodium octoxynol-9 sulfate. Int J Toxicol. 2004;23 (Suppl 1):59-111. [PubMed: 15162838]
Peralta O, Diaz S, Juez G et al. Fertility regulation in nursing women: V. Long-term influence of a low-dose combined oral contraceptive initiated at day 90 postpartum on lactation and infant growth. Contraception. 1983;27:27-38. [PubMed: 6404597]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

  • Breast Feeding
  • Lactation
  • Contraceptive Agents
  • Spermatocidal Agents

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Further information

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