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Nexcede Side Effects

Generic Name: ketoprofen

Note: This page contains side effects data for the generic drug ketoprofen. It is possible that some of the dosage forms included below may not apply to the brand name Nexcede.

For the Consumer

Applies to ketoprofen: oral capsule, oral capsule extended release, oral solution, oral syrup, oral tablet, oral tablet enteric coated, oral tablet extended release

As well as its needed effects, ketoprofen (the active ingredient contained in Nexcede) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking ketoprofen, check with your doctor immediately:

More common:
  • Abdominal pain
  • bloody urine
  • decreased frequency or amount of urine
  • headache
  • increased blood pressure
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • nausea
  • swelling of face, fingers, feet, or lower legs
  • troubled breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain
Less common:
  • Bladder pain
  • cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • rash
  • swelling or inflammation of the mouth
Rare
  • Back pain
  • bleeding from rectum
  • bleeding gums
  • blistering, peeling, loosening of skin
  • blood in vomit
  • bloody nose
  • bloody, black, or tarry stools
  • blurred vision
  • body aches or pain
  • burning feeling in chest or stomach
  • burning, dry or itching eyes
  • change in color of eye
  • chest pain
  • chills
  • clay-colored stools
  • cold hands and feet
  • coma
  • confusion
  • congestion
  • constipation
  • convulsions
  • cough or hoarseness
  • coughing or spitting up blood
  • cracks in the skin
  • dark urine
  • decreased urination
  • decreased vision or other changes in vision
  • diarrhea
  • difficult or labored breathing
  • difficulty swallowing
  • dilated neck veins
  • discharge, excessive tearing
  • dryness or soreness of throat
  • extreme fatigue
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling faint, dizzy, or lightheadedness
  • feeling of warmth or heat
  • fever with or without chills
  • flushing or redness of skin, especially on face and neck
  • general tiredness and weakness
  • heartburn
  • hives or welts
  • increased sensitivity of skin to sunlight
  • indigestion
  • itching
  • joint or muscle pain
  • light-colored stools
  • loss of heat from the body
  • muscle pain or cramps
  • nervousness
  • noisy breathing
  • pale or blue lips, fingernails, or skin
  • pale skin
  • pinpoint red or purple spots on skin
  • pounding in the ears
  • problems with bleeding or clotting
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • redness or other discoloration of skin
  • redness or soreness around fingernails or loosening of the fingernails
  • redness, pain, swelling of eye, eyelid, or inner lining of eyelid
  • runny nose
  • scaly skin
  • severe abdominal cramping
  • severe or continuing stomach pain
  • severe sunburn
  • shortness of breath
  • skin rash, encrusted, scaly and oozing
  • slow heartbeat
  • slow or irregular breathing
  • sores, ulcers, or white spots on lips or in mouth
  • stomach pain or upset
  • sweating
  • swelling of face, ankles, or hands
  • tender, swollen glands in neck
  • tenderness in stomach area
  • tightness in chest
  • trouble in swallowing
  • troubled breathing with exertion
  • unpleasant breath odor
  • unusual bleeding or bruising
  • upper right abdominal pain
  • voice changes
  • vomiting of blood
  • vomiting of material that looks like coffee grounds, severe and continuing
  • wheezing
  • yellow eyes or skin
Symptoms of overdose:
  • Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fast or shallow breathing
  • pain or discomfort in chest, upper stomach, or throat
  • unusual drowsiness, dullness, tiredness, weakness or feeling of sluggishness

Minor Side Effects

Some ketoprofen side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Acid or sour stomach
  • belching
  • bloated
  • discouragement
  • dreams
  • excess air or gas in stomach or intestines
  • excitation
  • feeling sad or empty
  • full feeling
  • general feeling of discomfort or illness
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • passing gas
  • sleepiness
  • sleeplessness
  • trouble concentrating
  • trouble sleeping
  • unable to sleep
Less common:
  • Continuing ringing or buzzing or other unexplained noise in ears
  • disturbed color perception
  • double vision
  • halos around lights
  • hearing loss
  • loss of vision
  • night blindness
  • overbright appearance of lights
  • tunnel vision
  • weight loss

For Healthcare Professionals

Applies to ketoprofen: compounding powder, oral capsule, oral capsule extended release, oral tablet

General

The most frequently reported side effects were gastrointestinal in nature and included dyspepsia, abdominal pain, nausea, diarrhea, constipation, and flatulence.[Ref]

Gastrointestinal

Very common (10% or more): Dyspepsia (up to 11.5%)
Common (1% to 10%): Abdominal pain, diarrhea, constipation, flatulence, anorexia, vomiting, stomatitis, nausea, gastralgia
Uncommon (0.1% to 1%): Gastritis
Rare (0.01% to 0.1%): Peptic ulcer
Very rare (less than 0.01%): Pancreatitis
Frequency not reported: Dry mouth, eructation, gastritis, rectal hemorrhage, melena, fecal occult blood, salivation, gastrointestinal (GI) perforation, hematemesis, intestinal ulceration, buccal necrosis, ulcerative colitis, microvesicular steatosis, ulcerative colitis exacerbated, Crohn's disease exacerbated, GI bleeding, mouth ulcer, sore tongue, GI hemorrhage[Ref]

Nervous system

Common (1% to 10%): Headache, central nervous system (CNS) inhibition, CNS excitation, somnolence, dizziness
Rare (less than 0.1%): Paresthesia
Frequency not reported: Amnesia, migraine, taste perversion, convulsions, drowsiness, dysgeusia, optic neuritis[Ref]

Cardiovascular

Frequency not reported: Hypertension, palpitation, tachycardia, congestive heart failure, peripheral vascular disease, vasodilation, shock, arrhythmia, myocardial infarction, heart failure exacerbated, atrial fibrillation, flushing, vasculitis[Ref]

Hepatic

Rare (less than 0.1%): Hepatitis, transaminases increased, bilirubin elevated
Frequency not reported: Hepatic dysfunction, hepatitis, cholestatic hepatitis, jaundice, liver function abnormal[Ref]

Renal

Frequency not reported: Renal failure/acute renal failure, interstitial nephritis, nephrotic syndrome, renal function tests abnormal, acute tubulopathy[Ref]

Psychiatric

Common (1% to 10%): Depression, insomnia, nervousness
Frequency not reported: Confusion, dysphoria, hallucination, libido disturbance, nightmares, personality disorder, tension, anxiety, mood altered[Ref]

Dermatologic

Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Pruritus
Frequency not reported: Purpura, alopecia, eczema, purpuric rash, sweating, urticaria, bullous rash, exfoliative dermatitis, photosensitivity, skin discoloration, onycholysis, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome, angioedema, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, bruising[Ref]

Ocular

Common (1% to 10%): Visual disturbance
Frequency not reported: Conjunctivitis, conjunctivitis sicca, eye pain, retinal hemorrhage, retinal pigmentation change[Ref]

Genitourinary

Common (1% to 10%): Urinary tract irritated
Frequency not reported: Impotence, menometrorrhagia, hematuria, gynecomastia[Ref]

Hematologic

Rare (less than 0.1%): Anemia, hemorrhagic anemia
Frequency not reported: Hypocoagulability, agranulocytosis, hemolysis, thrombocytopenia, neutropenia, bone marrow failure, bone marrow aplasia, hemolytic anemia, leukopenia[Ref]

Respiratory

Rare (less than 0.1%): Asthma/asthma attack
Frequency not reported: Dyspnea, hemoptysis, epistaxis, pharyngitis, rhinitis, bronchospasm, laryngeal edema[Ref]

Metabolic

Frequency not reported: Appetite increased, hyponatremia, diabetes mellitus aggravated, hyperkalemia[Ref]

Musculoskeletal

Frequency not reported: Myalgia[Ref]

Immunologic

Rare (less than 0.1%): Anaphylaxis
Frequency not reported: Allergic reaction[Ref]

Local

Frequency not reported: Rectal bleeding, rectal pain, rectal burning, rectal pruritus, rectal tenesmus[Ref]

Other

Common (1% to 10%): Malaise, tinnitus, edema, BUN increased
Uncommon (0.1% to 1%): Fatigue
Rare (less than 0.1%): Weight gain
Frequency not reported: Infection, pain, facial edema, chills, weight loss, thirst, vertigo, hearing impaired, septicemia, aseptic meningitis[Ref]

References

1. "Product Information. Ketoprofen ER (ketoprofen)." Mylan Pharmaceuticals Inc, Morgantown, WV.

2. "Product Information. Ketoprofen (ketoprofen)." Teva Pharmaceuticals USA, North Wales, PA.

3. MHRA. Medicines and Health Regulatory Agency "MHRA Drug Safety Update. Available from: URL: http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate."

4. Cerner Multum, Inc. "Australian Product Information." O 0

5. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of Nexcede may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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