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Nexcede Side Effects

Generic name: ketoprofen

Medically reviewed by Last updated on Jan 12, 2024.

Note: This document contains side effect information about ketoprofen. Some dosage forms listed on this page may not apply to the brand name Nexcede.

Applies to ketoprofen: oral capsule, oral capsule extended release.


Oral route (Tablet; Capsule; Capsule, Extended Release)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Ketoprofen is contraindicated for the treatment of perioperative pain in the setting of CABG surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.

Serious side effects of Nexcede

Along with its needed effects, ketoprofen (the active ingredient contained in Nexcede) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ketoprofen:

More common

Less common


Symptoms of overdose

Other side effects of Nexcede

Some side effects of ketoprofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to ketoprofen: compounding powder, oral capsule, oral capsule extended release, oral tablet.


The most frequently reported side effects were gastrointestinal in nature and included dyspepsia, abdominal pain, nausea, diarrhea, constipation, and flatulence.[Ref]


Very common (10% or more): Dyspepsia (up to 11.5%)

Common (1% to 10%): Abdominal pain, diarrhea, constipation, flatulence, anorexia, vomiting, stomatitis, nausea, gastralgia

Uncommon (0.1% to 1%): Gastritis

Rare (0.01% to 0.1%): Peptic ulcer

Very rare (less than 0.01%): Pancreatitis

Frequency not reported: Dry mouth, eructation, gastritis, rectal hemorrhage, melena, fecal occult blood, salivation, gastrointestinal (GI) perforation, hematemesis, intestinal ulceration, buccal necrosis, ulcerative colitis, microvesicular steatosis, ulcerative colitis exacerbated, Crohn's disease exacerbated, GI bleeding, mouth ulcer, sore tongue, GI hemorrhage[Ref]

Nervous system

Common (1% to 10%): Headache, central nervous system (CNS) inhibition, CNS excitation, somnolence, dizziness

Rare (less than 0.1%): Paresthesia

Frequency not reported: Amnesia, migraine, taste perversion, convulsions, drowsiness, dysgeusia, optic neuritis[Ref]


Frequency not reported: Hypertension, palpitation, tachycardia, congestive heart failure, peripheral vascular disease, vasodilation, shock, arrhythmia, myocardial infarction, heart failure exacerbated, atrial fibrillation, flushing, vasculitis[Ref]


Rare (less than 0.1%): Hepatitis, transaminases increased, bilirubin elevated

Frequency not reported: Hepatic dysfunction, hepatitis, cholestatic hepatitis, jaundice, liver function abnormal[Ref]


Frequency not reported: Renal failure/acute renal failure, interstitial nephritis, nephrotic syndrome, renal function tests abnormal, acute tubulopathy[Ref]


Common (1% to 10%): Depression, insomnia, nervousness

Frequency not reported: Confusion, dysphoria, hallucination, libido disturbance, nightmares, personality disorder, tension, anxiety, mood altered[Ref]


Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Pruritus

Frequency not reported: Purpura, alopecia, eczema, purpuric rash, sweating, urticaria, bullous rash, exfoliative dermatitis, photosensitivity, skin discoloration, onycholysis, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome, angioedema, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, bruising[Ref]


Common (1% to 10%): Visual disturbance

Frequency not reported: Conjunctivitis, conjunctivitis sicca, eye pain, retinal hemorrhage, retinal pigmentation change[Ref]


Common (1% to 10%): Urinary tract irritated

Frequency not reported: Impotence, menometrorrhagia, hematuria, gynecomastia[Ref]


Rare (less than 0.1%): Anemia, hemorrhagic anemia

Frequency not reported: Hypocoagulability, agranulocytosis, hemolysis, thrombocytopenia, neutropenia, bone marrow failure, bone marrow aplasia, hemolytic anemia, leukopenia[Ref]


Rare (less than 0.1%): Asthma/asthma attack

Frequency not reported: Dyspnea, hemoptysis, epistaxis, pharyngitis, rhinitis, bronchospasm, laryngeal edema[Ref]


Frequency not reported: Appetite increased, hyponatremia, diabetes mellitus aggravated, hyperkalemia[Ref]


Frequency not reported: Myalgia[Ref]


Rare (less than 0.1%): Anaphylaxis

Frequency not reported: Allergic reaction[Ref]


Frequency not reported: Rectal bleeding, rectal pain, rectal burning, rectal pruritus, rectal tenesmus[Ref]


Common (1% to 10%): Malaise, tinnitus, edema, BUN increased

Uncommon (0.1% to 1%): Fatigue

Rare (less than 0.1%): Weight gain

Frequency not reported: Infection, pain, facial edema, chills, weight loss, thirst, vertigo, hearing impaired, septicemia, aseptic meningitis[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. Cerner Multum, Inc. "Australian Product Information."

3. MHRA. Medicines and Health Regulatory Agency (2013) MHRA Drug Safety Update.

4. (2016) "Product Information. Ketoprofen ER (ketoprofen)." Mylan Pharmaceuticals Inc

5. (2016) "Product Information. Ketoprofen (ketoprofen)." Teva Pharmaceuticals USA

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.