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Neulasta Side Effects

Generic Name: pegfilgrastim

Note: This document contains side effect information about pegfilgrastim. Some of the dosage forms listed on this page may not apply to the brand name Neulasta.

In Summary

Common side effects of Neulasta include: ostealgia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pegfilgrastim: subcutaneous solution

Along with its needed effects, pegfilgrastim (the active ingredient contained in Neulasta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pegfilgrastim:

More Common

  • Chills
  • cough
  • fever
  • sore throat
  • ulcers, sores, or white spots in the mouth


  • Bluish lips or skin
  • pain, left upper abdomen or shoulder
  • tightness in the chest
  • troubled breathing

Incidence Not Known

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • blisters in the skin
  • blood in the urine
  • cloudy urine
  • decrease in how much or how often you urinate
  • difficulty with swallowing
  • dizziness
  • fainting or lightheadedness
  • fast heartbeat
  • flushing or redness of the skin
  • hives or welts, skin rash
  • itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea
  • sores on the skin
  • stomach pain
  • swelling of the hands, ankles, feet, or lower legs
  • unusual tiredness or weakness
  • unusually warm skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking pegfilgrastim:

Symptoms of Overdose

  • Bone pain
  • chest pain
  • difficult or labored breathing
  • eye pain
  • general feeling of illness
  • headache

Some side effects of pegfilgrastim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Incidence Not Known

  • Body produces substance that can bind to drug making it less effective or cause side effects

For Healthcare Professionals

Applies to pegfilgrastim: subcutaneous solution


Uncommon (0.1% to 1%): Capillary leak syndrome[Ref]


Uncommon (0.1% to 1%): Acute febrile dermatosis (Sweet's syndrome), cutaneous vasculitis[Ref]


Very common (10% or more): Nausea[Ref]


Common (1% to 10%): Thrombocytopenia, leukocytosis

Uncommon (0.1% to 1%): Sickle cell crisis, splenomegaly, splenic rupture[Ref]


Uncommon (0.1% to 1%): Hypersensitivity reactions, anaphylaxis[Ref]


Common (1% to 10%): Injection site pain, noncardiac chest pain

Uncommon (0.1% to 1%): Injection site erythema[Ref]


Common (1% to 10%): Transient elevations in aspartate aminotransferase (AST) or alanine aminotransferase (ALT)[Ref]


Common (1% to 10%): Elevated uric acid

Uncommon (0.1% to 1%): Elevated lactate dehydrogenase, elevated alkaline phosphatase (ALP)[Ref]


Very common (10% or more): Bone pain (26%)

Common (1% to 10%): Myalgia, arthralgia, pain in extremity, back pain, musculoskeletal pain, neck pain[Ref]

Nervous system

Very common (10% or more): Headache[Ref]


Uncommon (0.1% to 1%): Acute respiratory distress syndrome, interstitial pneumonia, pulmonary edema, pulmonary infiltrates, pulmonary fibrosis[Ref]


Uncommon (0.1% to 1%): Glomerulonephritis[Ref]


Common (1% to 10%): Preexisting binding antibodies


1. "Product Information. Neulasta (pegfilgrastim)." Amgen, Thousand Oaks, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.