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Neulasta Side Effects

Generic Name: pegfilgrastim

Note: This document contains side effect information about pegfilgrastim. Some of the dosage forms listed on this page may not apply to the brand name Neulasta.

In Summary

Common side effects of Neulasta include: ostealgia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pegfilgrastim: subcutaneous solution

Along with its needed effects, pegfilgrastim (the active ingredient contained in Neulasta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pegfilgrastim:

More common
  • Chills
  • cough
  • fever
  • sore throat
  • ulcers, sores, or white spots in the mouth
Rare
  • Bluish lips or skin
  • pain, left upper abdomen or shoulder
  • tightness in the chest
  • troubled breathing
Incidence not known
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • blisters in the skin
  • blood in the urine
  • cloudy urine
  • decrease in how much or how often you urinate
  • difficulty with swallowing
  • dizziness
  • fainting or lightheadedness
  • fast heartbeat
  • flushing or redness of the skin
  • hives or welts or skin rash
  • itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea
  • sores on the skin
  • stomach pain
  • swelling of the hands, ankles, feet, or lower legs
  • unusual tiredness or weakness
  • unusually warm skin

Some side effects of pegfilgrastim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • belching
  • bone pain
  • change in sense of taste
  • constipation
  • cracked lips
  • diarrhea
  • hair loss or thinning of the hair
  • headache
  • heartburn
  • indigestion
  • joint pain
  • lack or loss of strength
  • loss of appetite
  • muscle soreness
  • swelling of the hands, ankles, feet, or lower legs
  • swelling or inflammation of the mouth
  • trouble sleeping
  • vomiting
  • weakness, generalized
  • weight loss
Incidence not known
  • Body produces substance that can bind to drug making it less effective or cause side effects

For Healthcare Professionals

Applies to pegfilgrastim: subcutaneous solution

Cardiovascular

Uncommon (0.1% to 1%): Capillary leak syndrome[Ref]

Dermatologic

Uncommon (0.1% to 1%): Acute febrile dermatosis (Sweet's syndrome), cutaneous vasculitis[Ref]

Gastrointestinal

Very common (10% or more): Nausea[Ref]

Hematologic

Common (1% to 10%): Thrombocytopenia, leukocytosis
Uncommon (0.1% to 1%): Sickle cell crisis, splenomegaly, splenic rupture[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity reactions, anaphylaxis[Ref]

Local

Common (1% to 10%): Injection site pain, noncardiac chest pain
Uncommon (0.1% to 1%): Injection site erythema[Ref]

Hepatic

Common (1% to 10%): Transient elevations in aspartate aminotransferase (AST) or alanine aminotransferase (ALT)[Ref]

Metabolic

Common (1% to 10%): Elevated uric acid
Uncommon (0.1% to 1%): Elevated lactate dehydrogenase, elevated alkaline phosphatase (ALP)[Ref]

Musculoskeletal

Very common (10% or more): Bone pain (26%)
Common (1% to 10%): Myalgia, arthralgia, pain in extremity, back pain, musculoskeletal pain, neck pain[Ref]

Nervous system

Very common (10% or more): Headache[Ref]

Respiratory

Uncommon (0.1% to 1%): Acute respiratory distress syndrome, interstitial pneumonia, pulmonary edema, pulmonary infiltrates, pulmonary fibrosis[Ref]

Renal

Uncommon (0.1% to 1%): Glomerulonephritis[Ref]

References

1. "Product Information. Neulasta (pegfilgrastim)." Amgen, Thousand Oaks, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Some side effects of Neulasta may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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