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Neulasta Side Effects

Generic Name: pegfilgrastim

Note: This page contains side effects data for the generic drug pegfilgrastim. It is possible that some of the dosage forms included below may not apply to the brand name Neulasta.

In Summary

Common side effects of Neulasta include: ostealgia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pegfilgrastim: subcutaneous solution

As well as its needed effects, pegfilgrastim (the active ingredient contained in Neulasta) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking pegfilgrastim, check with your doctor immediately:

More common:
  • Chills
  • cough
  • fever
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • Bluish lips or skin
  • pain, left upper abdomen or shoulder
  • tightness in the chest
  • troubled breathing
Incidence not known:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • blisters in the skin
  • blood in the urine
  • cloudy urine
  • decrease in how much or how often you urinate
  • difficulty with swallowing
  • dizziness
  • fainting or lightheadedness
  • fast heartbeat
  • flushing or redness of the skin
  • hives or welts or skin rash
  • itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea
  • sores on the skin
  • stomach pain
  • swelling of the hands, ankles, feet, or lower legs
  • unusual tiredness or weakness
  • unusually warm skin

Minor Side Effects

Some pegfilgrastim side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Acid or sour stomach
  • belching
  • bone pain
  • change in sense of taste
  • constipation
  • cracked lips
  • diarrhea
  • hair loss or thinning of the hair
  • headache
  • heartburn
  • indigestion
  • joint pain
  • lack or loss of strength
  • loss of appetite
  • muscle soreness
  • swelling of the hands, ankles, feet, or lower legs
  • swelling or inflammation of the mouth
  • trouble sleeping
  • vomiting
  • weakness, generalized
  • weight loss
Incidence not known:
  • Body produces substance that can bind to drug making it less effective or cause side effects

For Healthcare Professionals

Applies to pegfilgrastim: subcutaneous solution


Uncommon (0.1% to 1%): Capillary leak syndrome[Ref]


Uncommon (0.1% to 1%): Acute febrile dermatosis (Sweet's syndrome), cutaneous vasculitis[Ref]


Very common (10% or more): Nausea[Ref]


Common (1% to 10%): Thrombocytopenia, leukocytosis
Uncommon (0.1% to 1%): Sickle cell crisis, splenomegaly, splenic rupture[Ref]


Uncommon (0.1% to 1%): Hypersensitivity reactions, anaphylaxis[Ref]


Common (1% to 10%): Injection site pain, noncardiac chest pain
Uncommon (0.1% to 1%): Injection site erythema[Ref]


Common (1% to 10%): Transient elevations in aspartate aminotransferase (AST) or alanine aminotransferase (ALT)[Ref]


Common (1% to 10%): Elevated uric acid
Uncommon (0.1% to 1%): Elevated lactate dehydrogenase, elevated alkaline phosphatase (ALP)[Ref]


Very common (10% or more): Bone pain (26%)
Common (1% to 10%): Myalgia, arthralgia, pain in extremity, back pain, musculoskeletal pain, neck pain[Ref]

Nervous system

Very common (10% or more): Headache[Ref]


Uncommon (0.1% to 1%): Acute respiratory distress syndrome, interstitial pneumonia, pulmonary edema, pulmonary infiltrates, pulmonary fibrosis[Ref]


Uncommon (0.1% to 1%): Glomerulonephritis[Ref]


1. "Product Information. Neulasta (pegfilgrastim)." Amgen, Thousand Oaks, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of Neulasta may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.