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Neratinib Side Effects

For the Consumer

Applies to neratinib: oral tablet

Along with its needed effects, neratinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking neratinib:

More common Less common
  • Confusion
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • increase in heart rate
  • lightheadedness
  • rapid breathing
  • sunken eyes
  • thirst
  • unusual tiredness or weakness
  • wrinkled skin
Rare
  • Bloody urine
  • increased blood pressure
  • increased thirst
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • loss of appetite
  • lower back or side pain
  • nausea
  • raised, firm, bright red patches of skin on the arm or leg
  • stomach pain
  • swelling of the face, fingers, or lower legs
  • troubled breathing
  • vomiting
  • weight gain

Some side effects of neratinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Belching
  • bladder pain
  • bloody nose
  • bloody or cloudy urine
  • decreased appetite
  • decreased weight
  • difficult, burning, or painful urination
  • discoloration of the fingernails or toenails
  • dry skin
  • frequent urge to urinate
  • heartburn
  • indigestion
  • muscle spasms
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth
Less common
  • Deep cracks, grooves, or lines in the skin
  • dry mouth

For Healthcare Professionals

Applies to neratinib: oral tablet

General

The most common adverse reactions (more than 5%) were diarrhea, nausea, abdominal pain, fatigue, vomiting, rash, stomatitis, decreased appetite, muscle spasms, dyspepsia, increased AST or ALT, nail disorder, dry skin, abdominal distention, decreased weight, and urinary tract infection.[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (95%), nausea (43%), abdominal pain (36%), vomiting (26%), stomatitis (14%), dyspepsia (10%)
Common (1% to 10%): Abdominal distention, dry mouth[Ref]

Other

Very common (10% or more): Fatigue (27%)[Ref]

Dermatologic

Very common (10% or more): Rash (18%)
Common (1% to 10%): Nail disorder, rash, skin fissures[Ref]

Metabolic

Very common (10% or more): Decreased appetite (12%)
Common (1% to 10%): Decreased weight, dehydration[Ref]

Musculoskeletal

Very common (10% or more): Muscle spasms (11%)[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Hepatic

Common (1% to 10%): Increased ALT, increased AST[Ref]

Respiratory

Common (1% to 10%): Epistaxis[Ref]

Cardiovascular

Frequency not reported: Hypotension[Ref]

Renal

Frequency not reported: Renal failure[Ref]

References

1. "Product Information. Nerlynx (neratinib)." Puma Biotechnology, Inc., Los Angeles, CA.

Some side effects of neratinib may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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