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Nelarabine Side Effects

In Summary

Commonly reported side effects of nelarabine include: febrile neutropenia, paresthesia, peripheral sensory neuropathy, anemia, leukopenia, neutropenia, and thrombocytopenia. Other side effects include: peripheral motor neuropathy. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to nelarabine: intravenous solution

As well as its needed effects, nelarabine may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking nelarabine, check with your doctor immediately:

More common:
  • Abdominal pain or cramps
  • anxiety
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • bloody nose
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in walking and balance
  • chest pain
  • chills
  • clumsiness or unsteadiness
  • cold sweats
  • coma
  • convulsions
  • cool, pale skin
  • cough or hoarseness
  • decreased or uncontrolled urination
  • difficulty with breathing
  • discouragement
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • drowsiness
  • dry mouth
  • fast or irregular heartbeat
  • feeling sad or empty
  • feeling unusually cold
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • incoordination
  • increased hunger
  • increased thirst
  • increased urination
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • lower back, side, or stomach pain
  • mood or mental changes
  • muscle cramps in hands, arms, feet, legs, or face
  • muscle pain
  • muscle spasms (tetany) or twitching seizures
  • muscle weakness
  • nausea or vomiting
  • nervousness
  • nightmares
  • numbness, tingling, pain, or weakness in hands, feet, fingertips, or mouth
  • pain or tenderness around the eyes and cheekbones
  • painful or difficult urination
  • paralysis or severe weakness of legs
  • rapid breathing
  • seizures
  • shakiness and unsteady walk
  • shivering
  • shortness of breath
  • sleepiness or unusual drowsiness
  • sleeplessness
  • slurred speech
  • small red or purple spots on skin
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stuffy or runny nose
  • sunken eyes
  • sweating
  • swelling of hands, ankles, feet, or lower legs
  • swollen glands
  • tightness in chest
  • trouble concentrating
  • trouble sleeping
  • troubled breathing with exertion
  • unable to sleep
  • uncontrolled bowel movements
  • unexplained weight loss
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wheezing
  • wrinkled skin
  • yellow eyes or skin
Less common:
  • Change in taste
  • loss of memory
  • loss of taste
  • problems with memory

Minor Side Effects

Some nelarabine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Back pain
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • full or bloated feeling
  • joint pain
  • lack or loss of strength
  • muscle aching or stiffness
  • pain in the arms or legs
  • pressure in the stomach
  • swelling of the abdomen or stomach area
  • swelling or inflammation of the mouth
  • swollen joints

For Healthcare Professionals

Applies to nelarabine: intravenous solution

Hematologic

Hematologic side effects including anemia (99%), thrombocytopenia (86%), neutropenia (81%), and febrile neutropenia (12%) have been reported. A case of biopsy confirmed multifocal leukoencephalopathy has also been reported.[Ref]

Nervous system

Nervous system side effects (64%) have been reported including somnolence (23%), dizziness (21%), peripheral neurologic disorders (21%), hypoesthesia (17%), headache (15%), paresthesia (15%), ataxia (9%), depressed level of consciousness (6%), tremor (5%), amnesia (3%), dysgeusia (3%), balance disorder (2%), and sensory loss (2%). Neurologic disorders have included peripheral sensory neuropathy (13%), peripheral motor neuropathy (7%), peripheral neuropathy (5%), neuropathy (4%), demyelination, and ascending peripheral neuropathies similar in appearance to Guillain-Barre syndrome.[Ref]

Other

There were four reported additional fatalities unrelated to treatment with nelarabine.[Ref]

Other side effects have included reports of sometimes fatal opportunistic infections in patients receiving nelarabine. A fatal case of cerebral hemorrhage/coma/leukoencephalopathy which was thought to be related to treatment with nelarabine has also been reported.[Ref]

Gastrointestinal

Gastrointestinal side effects including nausea (41%), diarrhea (22%), vomiting (22%), constipation (21%), abdominal pain (9%), anorexia (9%), stomatitis (8%), and abdominal distention (6%) have been reported.[Ref]

General

General side effects including fatigue (50%), pyrexia (23%), asthenia (17%), peripheral edema (15%), edema (11%), pain (11%), infection (9%), rigors (8%), dehydration (7%), abnormal gait (6%), chest pain (5%), and noncardiac chest pain (5%) have been reported.[Ref]

Respiratory

Respiratory side effects including cough (25%), dyspnea (20%), pleural effusion (10%), epistaxis (8%), pneumonia (8%), exertional dyspnea (7%), sinusitis (7%), and wheezing (5%) have been reported.[Ref]

Hepatic

Hepatic side effects including increased AST (6%) have been reported.[Ref]

Metabolic

Metabolic side effects including hyperglycemia (6%) and tumor lysis syndrome have been reported.[Ref]

Musculoskeletal

Musculoskeletal side effects including myalgia (13%), arthralgia (9%), back pain (8%), muscular weakness (8%), and pain in extremity (7%) have been reported. Postmarketing reports of rhabdomyolysis and increased blood creatine phosphokinase have been received.[Ref]

Psychiatric

Psychiatric side effects including confusional state (8%), insomnia (7%), and depression (6%) have been reported.[Ref]

Cardiovascular

Cardiovascular side effects including sinus tachycardia (8%) and hypotension (8%) have been reported.[Ref]

Dermatologic

Dermatologic side effects including petechiae (12%) have been reported.[Ref]

Ocular

Ocular side effects including blurred vision (4%) has been reported.[Ref]

References

1. "Product Information. Arranon (nelarabine)." GlaxoSmithKline, Research Triangle Park, NC.

It is possible that some side effects of nelarabine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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