Naltrexone / Oxycodone Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 17, 2024.

Applies to naltrexone / oxycodone: oral capsule extended release.

General adverse events

The most frequently reported adverse effects have included nausea, constipation, vomiting, headache, and somnolence.^[Ref]

Respiratory

• Common (1% to 10%): Oropharyngeal pain, cough
• Frequency not reported: Rhinorrhea, chronic bronchitis, dyspnea, dysphonia^[Ref]

Rhinorrhea, chronic bronchitis, dyspnea, and dysphonia were reported in less than 2% of patients.^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (up to 20.5%), constipation (up to 14.9%)
• Common (1% to 10%): Abdominal pain, diarrhea, dry mouth, nausea
• Frequency not reported: Dyspepsia^[Ref]

Dyspepsia was reported in less than 2% of patients.^[Ref]

Hypersensitivity

• Frequency not reported: Drug hypersensitivity
• Postmarketing reports: Anaphylaxis, pharyngeal edema^[Ref]

Drug hypersensitivity was reported in less than 2% of patients. Anaphylaxis and pharyngeal edema have been reported with ingredients contained in this drug.^[Ref]

Cardiovascular

• Common (1% to 10%): Peripheral edema
• Frequency not reported: Tachycardia, palpitations, bradycardia, chest pain, increased blood pressure
• Postmarketing reports: Myocardial ischemia, ventricular fibrillation (with oxycodone overdose)^[Ref]

Tachycardia, palpitations, bradycardia, chest pain, and increased blood pressure were reported in less than 2% of patients.^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia, depression, restlessness
• Frequency not reported: Irritability, abnormal dreams, confusional state, disorientation, decreased libido, drug abuse^[Ref]

Irritability, abnormal dreams, confusional state, disorientation, decreased libido, and drug abuse were reported in less than 2% of patients.^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache, hypoesthesia, somnolence, tremor
• Postmarketing reports: Serotonin syndrome^[Ref]

Postmarketing reports of serotonin syndrome have been received among patients with concomitant use of opioids and serotonergic drugs.^[Ref]

Dermatologic

• Common (1% to 10%): Hyperhidrosis, pruritus
• Frequency not reported: Rash, urticaria^[Ref]

Rash and urticaria were reported in less than 2% of patients.^[Ref]

Endocrine

• Frequency not reported: Decreased blood testosterone
• Postmarketing reports: Adrenal insufficiency, androgen deficiency^[Ref]

Decreased blood testosterone was reported in less than 2% of patients.^[Ref]

Genitourinary

• Frequency not reported: Dysuria, hematuria^[Ref]

Dysuria and hematuria were reported in less than 2% of patients.^[Ref]

Hematologic

• Frequency not reported: Anemia, lymphadenopathy^[Ref]

Anemia and lymphadenopathy were reported in less than 2% of patients.^[Ref]

Hepatic

• Frequency not reported: Abnormal liver function test^[Ref]

Abnormal liver function test was reported in less than 2% of patients.^[Ref]

Metabolic

• Frequency not reported: Decreased appetite, gout^[Ref]

Decreased appetite and gout were reported in less than 2% of patients.^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain, arthralgia, muscle spasms
• Frequency not reported: Myalgia, muscle twitching, musculoskeletal stiffness, arthritis^[Ref]

Myalgia, muscle twitching, musculoskeletal stiffness, and arthritis were reported in less than 2% of patients.^[Ref]

Ocular

• Frequency not reported: Increased lacrimation^[Ref]

Increased lacrimation was reported in less than 2% of patients.^[Ref]

Other

• Common (1% to 10%): Drug withdrawal syndrome, fatigue, hot flush
• Frequency not reported: Vertigo, tinnitus, chills, pain, influenza like illness, pyrexia, malaise, intentional surgical and medical procedure misuse^[Ref]

Vertigo, tinnitus, chills, pain, influenza like illness, pyrexia, malaise, and intentional surgical/medical procedure misuse were reported in less than 2% of patients.^[Ref]

Further information

Naltrexone/oxycodone side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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