Nallpen Side Effects
Generic name: nafcillin
Medically reviewed by Drugs.com. Last updated on Jul 22, 2022.
Note: This document contains side effect information about nafcillin. Some dosage forms listed on this page may not apply to the brand name Nallpen.
Applies to nafcillin: parenteral injection, parenteral powder for injection.
Side effects include:
Hypersensitivity reactions; local reactions (phlebitis, thrombophlebitis); renal, hepatic, or nervous system effects with high dosage.
For Healthcare Professionals
Applies to nafcillin: injectable powder for injection, intravenous solution, oral capsule.
Common (1% to 10%): Allergic reactions (included immediate and delayed reactions)
Very rare (less than 0.01%): Anaphylactic shock resulting in death
Frequency not reported: Immediate allergic reaction (included urticaria, pruritus, angioedema, laryngospasm, bronchospasm, hypotension, vascular collapse, death), anaphylaxis, accelerated immediate allergic reaction (included urticaria, pruritus, fever, laryngeal edema, laryngospasm, hypotension), delayed allergic reaction (included serum sickness-like reactions [i.e., fever, malaise, urticaria, myalgia, arthralgia, abdominal pain], various skin rashes)[Ref]
Immediate allergic reactions usually occurred within 20 minutes of administration and ranged in severity from urticaria and pruritus to angioedema, laryngospasm, bronchospasm, hypotension, vascular collapse, and death; such immediate anaphylactic reactions were very rare and usually occurred after parenteral therapy but have occurred with oral therapy. An accelerated immediate allergic reaction has occurred between 20 minutes and 48 hours after administration and has included urticaria, pruritus, and fever; although laryngeal edema, laryngospasm, and hypotension occasionally occurred, fatality was uncommon.
Delayed allergic reactions to penicillin therapy usually occurred after 48 hours and sometimes as late as 2 to 4 weeks after starting therapy. Manifestations of this reaction included serum sickness-like symptoms (i.e., fever, malaise, urticaria, myalgia, arthralgia, abdominal pain) and various skin rashes.[Ref]
Frequency not reported: Rash, urticaria, pruritus[Ref]
At least 3 cases of platelet dysfunction with prolonged bleeding times have been reported with this drug. All cases resolved after this drug was discontinued.[Ref]
Elevated liver transaminases and cholestasis have been reported, especially with high doses.[Ref]
Frequency not reported: Elevated liver transaminases, cholestasis, hepatotoxicity[Ref]
Frequency not reported: IV injection site pain, IV injection site swelling, IV injection site inflammation, IV injection site phlebitis, IV injection site thrombophlebitis, skin sloughing at IV injection site, severe tissue necrosis with sloughing (secondary to subcutaneous extravasation), pain at IM injection site[Ref]
Frequency not reported: Neurotoxic reactions, neurotoxicity[Ref]
Neurotoxic reactions (similar to those observed with penicillin G) have occurred with large IV or intraventricular doses, especially in patients with concurrent liver and renal dysfunction.[Ref]
Frequency not reported: Fever[Ref]
Frequency not reported: Hematuria, proteinuria[Ref]
More about Nallpen (nafcillin)
- Check interactions
- Dosage information
- During pregnancy
- Drug class: penicillinase resistant penicillins
Related treatment guides
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Some side effects may not be reported. You may report them to the FDA.