Nafcillin Side Effects
For the Consumer
Applies to nafcillin: injectable powder for injection, intravenous solution
Get emergency medical help if you have signs of an allergic reaction: hives, itching; fever, stomach pain, muscle or joint pain; difficulty breathing; swelling of your face, lips, tongue, or throat.
A delayed allergic reaction to nafcillin can occur as few as 2 days to as many as 4 weeks after you use the medication.
Call your doctor at once if you have:
severe stomach pain, diarrhea that is watery or bloody;
fever, swollen glands, joint pain, general ill feeling;
blood in your urine, urinating less than usual or not at all;
skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or
pain, swelling, bruising, or skin changes where the medicine was injected.
Common side effects may include:
nausea, vomiting, diarrhea;
black or "hairy" tongue; or
tenderness or irritation around the IV needle.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to nafcillin: injectable powder for injection, intravenous solution, oral capsule
Gastrointestinal side effects have included nausea, vomiting, diarrhea, stomatitis, black or hairy tongue, gastrointestinal irritation, and pseudomembranous colitis.[Ref]
Local side effects have included pain, swelling, phlebitis, thrombophlebitis, and skin sloughing after intravenous administration. Intramuscular injections may cause pain at the injection site. Extravasation may result in severe chemical irritation. Subcutaneous extravasation has been associated with severe tissue necrosis.[Ref]
Hypersensitivity reactions have included urticaria, pruritus, angioneurotic edema, laryngeal edema, laryngospasm, bronchospasm, hypotension, vascular collapse, anaphylaxis, serum sickness-like reactions, fever, and death.[Ref]
Hematologic side effects have included agranulocytosis, neutropenia, bone marrow depression, and platelet dysfunction. These reactions are usually reversible upon discontinuation of nafcillin.[Ref]
At least three cases of platelet dysfunction with prolonged bleeding times have been reported with nafcillin therapy. All cases resolved following discontinuation of nafcillin.[Ref]
Renal side effects have included renal tubular damage and interstitial nephritis. Symptoms may include rash, fever, eosinophilia, hematuria, proteinuria, and renal insufficiency.[Ref]
Hepatic adverse effects are rare, but cases of hepatotoxicity associated with nafcillin therapy have been reported.[Ref]
Nervous system side effects have included neurotoxicity with high intravenous or intraventricular doses, especially in patients with both hepatic and renal impairment.[Ref]
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11. Alexander DP, Russo ME, Fohrman DE, Rothstein G "Nafcillin-induced platelet dysfunction and bleeding." Antimicrob Agents Chemother 23 (1983): 59-62
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13. Couchonnal GJ, Hinthorn DR, Hodges GR, Liu C "Nafcillin-associated granulocytopenia." South Med J 71 (1978): 1356-8
14. Andreoli SP, Kleiman MB, Glick MR, Bergstein JM "Nafcillin, pseudoproteinuria, and hypokalemic alkalosis." J Pediatr 97 (1980): 841-2
15. Bodendorfer TW "Nafcillin-induced interstitial nephritis." JAMA 244 (1980): 2609
16. Whitman CB, Wike MJ "Possible case of nafcillin-induced acute interstitial nephritis." Am J Health Syst Pharm 69 (2012): 1049-53
17. Mohr JA, Clark RM, Waack TC, Whang R "Nafcillin-associated hypokalemia." JAMA 242 (1979): 544
18. Barriere SL, Conte JE Jr "Absence of nafcillin-associated nephritis." West J Med 133 (1980): 472-7
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It is possible that some side effects of nafcillin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
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