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Mozobil Side Effects

Generic Name: plerixafor

Note: This page contains information about the side effects of plerixafor. Some of the dosage forms included on this document may not apply to the brand name Mozobil.

In Summary

Common side effects of Mozobil include: dizziness, diarrhea, nausea, injection site reaction, headache, fatigue, arthralgia, and vomiting. Other side effects include: flatulence. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to plerixafor: subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by plerixafor (the active ingredient contained in Mozobil). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking plerixafor:

More common:
  • Bleeding gums
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • collection of blood under skin
  • coughing up blood
  • deep, dark purple bruise
  • difficulty in breathing or swallowing
  • dizziness
  • feeling of heat
  • flushing, redness of the skin
  • hard lump
  • headache
  • hives or welts
  • increased menstrual flow or vaginal bleeding
  • irritation
  • itching skin
  • nosebleeds
  • pain
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • redness of the skin
  • shortness of breath
  • skin rash
  • swelling
  • unusually warm skin
  • Chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • fainting
  • fast heartbeat
  • swelling around the eyes
  • tightness in the chest
  • weakness
  • wheezing

Minor Side Effects

Some of the side effects that can occur with plerixafor may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Bloated
  • diarrhea
  • difficulty in moving
  • excess air or gas in stomach or intestines
  • full feeling
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • passing gas
  • sleeplessness
  • trouble sleeping
  • unable to sleep
  • unusual tiredness or weakness
  • vomiting
Less common:
  • Acid or sour stomach
  • belching
  • difficulty having a bowel movement (stool)
  • dry mouth
  • general feeling of discomfort or illness
  • heartburn
  • increased sweating
  • indigestion
  • muscle or bone pain
  • pressure in the stomach
  • stomach discomfort, upset, or pain
  • swelling of abdominal or stomach area

For Healthcare Professionals

Applies to plerixafor: subcutaneous solution


Very common (10% or more): Diarrhea (up to 37%), nausea (up to 34%), vomiting (up to 10%)
Common (1% to 10%): Flatulence, abdominal pain, abdominal distension, dry mouth, stomach discomfort, hypoesthesia oral, constipation, dyspepsia[Ref]


Very common (10% or more): Injection site reactions (up to 34%)[Ref]


Very common (10% or more): Fatigue (up to 27%)
Common (1% to 10%): Malaise[Ref]

Nervous system

Very common (10% or more): Headache (up to 22%), paresthesia (up to 20.6%), dizziness (up to 11%)
Uncommon (0.1% to 1%): Vasovagal reactions[Ref]


Very common (10% or more): Arthralgia (up to 13%)
Common (1% to 10%): Musculoskeletal pain[Ref]


Common (1% to 10%): Hyperhidrosis, erythema[Ref]


Common (1% to 10%): Hyperleukocytosis
Frequency not reported: Thrombocytopenia[Ref]


Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Abnormal dreams, nightmares[Ref]


Uncommon (0.1% to 1%): Allergic reactions
Postmarketing reports: Anaphylactic reactions including anaphylactic shock[Ref]


Rare (less than 0.1%): Myocardial infarction[Ref]


1. "Product Information. Mozobil (plerixafor)." Genzyme Corporation, Cambridge, MA.

Not all side effects for Mozobil may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.