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Mozobil Dosage

Generic name: PLERIXAFOR 24mg in 1.2mL
Dosage form: subcutaneous injection
Drug classes: Hematopoietic stem cell mobilizer, Other immunostimulants

Medically reviewed by Drugs.com. Last updated on Oct 5, 2023.

Recommended Dosage and Administration

Begin treatment with Mozobil after the patient has received filgrastim once daily for 4 days. Administer Mozobil approximately 11 hours prior to initiation of each apheresis for up to 4 consecutive days.

The recommended dose of Mozobil by subcutaneous injection is based on body weight:

  • 20 mg fixed dose or 0.24 mg/kg of body weight for patients weighing less than or equal to 83 kg.
  • 0.24 mg/kg of body weight for patients weighing greater than 83 kg

Use the patient's actual body weight to calculate the volume of Mozobil to be administered. Each vial delivers 1.2 mL of 20 mg/mL solution, and the volume to be administered to patients should be calculated from the following equation:

0.012 × patient's actual body weight (in kg) = volume to be administered (in mL)

In clinical studies, Mozobil dose has been calculated based on actual body weight in patients up to 175% of ideal body weight. Mozobil dose and treatment of patients weighing more than 175% of ideal body weight have not been investigated.

Based on increasing exposure with increasing body weight, the Mozobil dose should not exceed 40 mg/day.

Vials should be inspected visually for particulate matter and discoloration prior to administration and should not be used if there is particulate matter or if the solution is discolored.

Discard unused portion.

Recommended Concomitant Medications

Administer daily morning doses of filgrastim 10 mcg/kg for 4 days prior to the first evening dose of Mozobil and on each day prior to apheresis.

Dose Modifications in Renal Impairment

In patients with moderate and severe renal impairment (estimated creatinine clearance (CLCR) less than or equal to 50 mL/min), reduce the dose of Mozobil by one-third based on body weight category as shown in Table 1. If CLCR is less than or equal to 50 mL/min the dose should not exceed 27 mg/day, as the mg/kg-based dosage results in increased plerixafor exposure with increasing body weight. Similar systemic exposure is predicted if the dose is reduced by one-third in patients with moderate and severe renal impairment compared with subjects with normal renal function.

Table 1: Recommended Dosage of Mozobil in Patients with Renal Impairment
Estimated Creatinine Clearance
(mL/min)
Dose
Body Weight less than or equal to 83 kg Body Weight greater than 83 kg and less than 160 kg
greater than 50 20 mg or 0.24 mg/kg once daily 0.24 mg/kg once daily (not to exceed 40 mg/day)
less than or equal to 50 13 mg or 0.16 mg/kg once daily 0.16 mg/kg once daily (not to exceed 27 mg/day)

The following (Cockcroft-Gault) formula may be used to estimate CLCR:

Males:
Creatinine clearance (mL/min) = weight (kg) × (140 – age in years)
72 × serum creatinine (mg/dL)

Females:
Creatinine clearance (mL/min) = 0.85 × value calculated for males

There is insufficient information to make dosage recommendations in patients on hemodialysis.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.