Morphine Liposomal Side Effects

Applies to morphine liposomal: injectable suspension extended release.

General adverse events

The more commonly reported side effects have included nausea, pruritus, pyrexia, vomiting, hypotension, anemia, headache, constipation, decreased oxygen saturation, urinary retention, and dizziness.^[Ref]

Respiratory

• Very common (10% or more): Decreased oxygen saturation
• Common (1% to 10%): Hypoxia, respiratory depression, hypercapnia, dyspnea
• Postmarketing reports: Severe respiratory depression, involving apnea or respiratory arrest, and cardiac arrest^[Ref]

Prolonged and serious respiratory depression was reported when administration was associated with subarachnoid puncture. In these cases, respiratory depression occurred following apparent recovery from anesthesia (within 12 hours of administration).

Four percent of patients receiving this drug in clinical trials required treatment with narcotic antagonists for respiratory depression; 90% of respiratory depression events were reported within the first 24 hours. Delayed respiratory depression (occurring up to 48 hours postdose) was reported in 2% of patients; 0.6% of patients reported respiratory depression after more than 48 hours. During the postmarketing period, severe respiratory depression involving apnea or respiratory arrest have been reported following administration of labeled doses.^[Ref]

Nervous system

• Postmarketing reports: Central nervous system depression, including obtunded feeling, non-arousable condition, unresponsiveness, confusion, and lethargy^[Ref]

CNS depression, including obtunded feeling, non-arousable condition, unresponsiveness, confusion, and lethargy, has been reported. In most cases, there was concomitant administration of different narcotics or hypnotic/sedative medications in the post-operative period.^[Ref]

Cardiovascular

• Very common (10% or more): Hypotension
• Common (1% to 10%): Tachycardia, hypertension, bradycardia^[Ref]

Gastrointestinal

• Very common (10% or more): Vomiting, constipation, nausea
• Common (1% to 10%): Flatulence, paralytic ileus, dyspepsia, abdominal distension^[Ref]

Dermatologic

• Very common (10% or more): Pruritus
• Common (1% to 10%): Hypoesthesia, increased sweating^[Ref]

Musculoskeletal

• Common (1% to 10%): Rigors^[Ref]

Metabolic

• Common (1% to 10%): Hypokalemia

Psychiatric

• Common (1% to 10%): Anxiety

Hematologic

• Very common (10% or more): Anemia
• Common (1% to 10%): Decreased hematocrit^[Ref]

Genitourinary

• Very common (10% or more): Urinary retention
• Common (1% to 10%): Bladder spasm, oliguria^[Ref]

Further information

Morphine liposomal side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer