Morphine liposomal Side Effects
Applies to morphine liposomal: injectable suspension extended release
The more commonly reported side effects have included nausea, pruritus, pyrexia, vomiting, hypotension, anemia, headache, constipation, decreased oxygen saturation, urinary retention, and dizziness.[Ref]
Very common (10% or more): Decreased oxygen saturation
Prolonged and serious respiratory depression was reported when administration was associated with subarachnoid puncture. In these cases, respiratory depression occurred following apparent recovery from anesthesia (within 12 hours of administration).
Four percent of patients receiving this drug in clinical trials required treatment with narcotic antagonists for respiratory depression; 90% of respiratory depression events were reported within the first 24 hours. Delayed respiratory depression (occurring up to 48 hours postdose) was reported in 2% of patients; 0.6% of patients reported respiratory depression after more than 48 hours. During the postmarketing period, severe respiratory depression involving apnea or respiratory arrest have been reported following administration of labeled doses.[Ref]
CNS depression, including obtunded feeling, non-arousable condition, unresponsiveness, confusion, and lethargy, has been reported. In most cases, there was concomitant administration of different narcotics or hypnotic/sedative medications in the post-operative period.[Ref]
Very common (10% or more): Hypotension
Very common (10% or more): Vomiting, constipation, nausea
Very common (10% or more): Pruritus
Common (1% to 10%): Hypoesthesia, increased sweating[Ref]
Common (1% to 10%): Rigors[Ref]
Common (1% to 10%): Hypokalemia
Common (1% to 10%): Anxiety
Very common (10% or more): Anemia
Common (1% to 10%): Decreased hematocrit[Ref]
Very common (10% or more): Urinary retention
Common (1% to 10%): Bladder spasm, oliguria[Ref]
1. "Product Information. DepoDur (morphine liposomal)." Endo Laboratories LLC, Chadds Ford, PA.
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Some side effects may not be reported. You may report them to the FDA.