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Morphine liposomal Pregnancy and Breastfeeding Warnings

Morphine liposomal is also known as: DepoDur

Morphine liposomal Pregnancy Warnings

Morphine has been assigned to pregnancy category C by the FDA. No increased risk of congenital malformations in humans has been associated with use of morphine in pregnancy. There are no controlled data in human pregnancy. Morphine should only be given during pregnancy when benefit outweighs risk.

Morphine liposomal should not be administered for vaginal labor and delivery. Morphine liposomal has only been administered to women undergoing cesarean section following clamping of the umbilical cord. Chronic use of morphine in later pregnancy has been associated with neonatal withdrawal.

See references

Morphine liposomal Breastfeeding Warnings

Morphine is excreted into human milk in trace amounts. Adverse effects in the nursing infant are unlikely. Morphine is considered compatible with breast-feeding by the American Academy of Pediatrics.

See references

References for pregnancy information

  1. Koren G, Pastuszak A, Ito S "Drugs in pregnancy." N Engl J Med 338 (1998): 1128-37
  2. "Product Information. Roxanol (morphine)." Roxane Laboratories Inc, Columbus, OH.
  3. "Product Information. DepoDur (morphine liposomal)." Endo Laboratories LLC, Chadds Ford, PA.
  4. Way WL, Costley EC, Way EL "Respiratory sensitivity of the newborn infant to meperidine and morphine." Clin Pharmacol Ther 6 (1965): 454-61

References for breastfeeding information

  1. Spigset O "Anaesthetic agents and excretion in breast milk." Acta Anaesthesiol Scand 38 (1994): 94-103
  2. Way WL, Costley EC, Way EL "Respiratory sensitivity of the newborn infant to meperidine and morphine." Clin Pharmacol Ther 6 (1965): 454-61
  3. Benyhe S "Minireview: morphine: new aspects in the study of an ancient compound." Life Sci 55 (1994): 969-79
  4. "Product Information. Roxanol (morphine)." Roxane Laboratories Inc, Columbus, OH.
  5. "Product Information. DepoDur (morphine liposomal)." Endo Laboratories LLC, Chadds Ford, PA.

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