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Monistat 1-Day Pre-Filled Applicator Side Effects

Generic Name: tioconazole topical

Note: This page contains information about the side effects of tioconazole topical. Some of the dosage forms included on this document may not apply to the brand name Monistat 1-Day Pre-Filled Applicator.

For the Consumer

Applies to tioconazole topical: topical cream

In addition to its needed effects, some unwanted effects may be caused by tioconazole topical (the active ingredient contained in Monistat 1-Day Pre-Filled Applicator). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking tioconazole topical, check with your doctor or nurse as soon as possible:

Less common:
  • Burning
  • itching
  • redness
  • skin rash
  • swelling
  • or other signs of skin irritation not present before use of this medicine

For Healthcare Professionals

Applies to tioconazole topical: vaginal ointment w/applicator


Local side effects have been commonly reported. These have involved the genitourinary area (occurring in up to 7% of treated patients), and have included burning, itching, and, less commonly, pain, irritation, and dryness.[Ref]


Hypersensitivity side effects have included contact dermatitis in patients using a topical nail solution (not available in the US). Most patients had been using the product for several weeks when dermatitis developed. Cross-sensitivity to other imidazoles has been reported.[Ref]


1. Clissold SP, Heel RC "Tioconazole. A review of its antimicrobial activity and therapeutic use in superficial mycoses." Drugs 31 (1986): 29-51

2. "Product Information. Vagistat-1 (tioconazole)." Bristol-Myers Squibb, Princeton, NJ.

3. Stein GE, Gurwith D, Mummaw N, Gurwith M "Single-dose tioconazole compared with 3-day clotrimazole treatment in vulvovaginal candidiasis." Antimicrob Agents Chemother 29 (1986): 969-71

4. Onayemi O, Aldridge RD, Shaw S "Allergic contact dermatitis from tioconazole. A report of 2 cases." Contact Dermatitis 26 (1992): 193-4

5. Brunelli D, Vincenzi C, Morelli R, Tosti A "Contact dermatitis from tioconazole." Contact Dermatitis 27 (1992): 120

6. Piletta P, Pasche-Koo F, Saurat JH "Contact dermatitis from tioconazole mimicking "one hand two feet syndrome"." Contact Dermatitis 28 (1993): 308

7. Jones SK, Kennedy CT "Contact dermatitis from tioconazole." Contact Dermatitis 22 (1990): 122-3

8. Marren P, Powell S "Contact sensitivity to tioconazole and other imidazoles." Contact Dermatitis 27 (1992): 129-30

9. Faria A, Goncalo S, Goncalo M, Freitas C, Baptista PP "Allergic contact dermatitis from tioconazole." Contact Dermatitis 35 (1996): 250-2

10. Gibson G, Buckley A, Murphy GM "Allergic contact dermatitis from tioconazole without cross- sensitivity to other imidazoles." Contact Dermatitis 30 (1994): 308

11. Stubb S, Heikkila H, Reitamo S, Forstrom L "Contact allergy to tioconazole." Contact Dermatitis 26 (1992): 155-8

12. Quirino AP, Barros MA "Contact dermatitis from tioconazole." Contact Dermatitis 30 (1994): 240-1

13. Izu R, Aguirre A, Gonzalez M, Diaz-Perez JL "Contact dermatitis from tioconazole with cross-sensitivity to other imidazoles." Contact Dermatitis 26 (1992): 130-1

Not all side effects for Monistat 1-Day Pre-Filled Applicator may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

More about Monistat 1-Day Pre-Filled Applicator (tioconazole topical)

Consumer resources

Other brands: Tioconazole 1 Day, Vagistat-1

Professional resources

Other Formulations

Related treatment guides

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