Mezlocillin Side Effects
Applies to mezlocillin: injectable powder for injection
Mezlocillin is generally well-tolerated.[Ref]
Hypersensitivity reactions are usually mild. General skin reactions and eosinophilia occur in up to 3% of treated patients. As with other penicillins, hypersensitivity reactions may include urticarial rash, angioedema, pruritus, and, in rare cases, bronchospasm, hypotension, and anaphylaxis.[Ref]
Rare cases of interstitial nephritis related to mezlocillin are likely due to hypersensitivity. Intravenous administration may result in thrombophlebitis or vein irritation in rare cases.
Nausea, vomiting, and altered sensation of taste have been reported. Mild and transient elevations of liver function tests are rare. A rare case of cholestatic jaundice associated with mezlocillin has been reported.[Ref]
Elevations of BUN and serum creatinine have been reported, but may be related to underlying illness. Interstitial nephritis has been reported in rare cases.[Ref]
Mezlocillin may cause a false positive sulfosalicylic acid test for proteinuria.[Ref]
Hematologic side effects are uncommon. Leukopenia has been reported in less than 1% of patients. Leukopenia has been reported in 23% of patients with liver disease receiving beta-lactam antibiotics. Platelet dysfunction may occur in up to 25% of treated patients resulting in significantly prolonged bleeding times.[Ref]
Although not reported with mezlocillin, convulsions and neuromuscular hyperirritability may be potential side effects of penicillin derivatives.[Ref]
Rare cases of hypokalemia have been reported, but may have been due to factors other than mezlocillin therapy.[Ref]
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.