Applies to the following strengths: 1 g; 2 g; 3 g; 4 g; 20 g
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Urinary Tract Infection
Uncomplicated: 100 to 125 mg/kg/day. Usual dose 1.5 to 2 g IV or intramuscularly every 6 hours.
Complicated: 150 to 200 mg/kg/day. Usual dose 3 g IV every 6 hours.
Usual Adult Dose for Gonococcal Infection - Uncomplicated
1 to 2 g IV or intramuscularly for one dose. Probenecid 1 g may be given orally at the time of dosing or up to 30 minutes before.
Usual Adult Dose for Surgical Prophylaxis
4 g IV given 30 to 90 minutes prior to the start of surgery.
4 g IV given 6 hours and 12 hours later.
Usual Adult Dose for Cesarean Section
4 g IV as soon as the umbilical cord is clamped.
The second and third doses of 4 g should be given IV 4 and 8 hours after the first dose.
Renal Dose Adjustments
CrCl < 10 mL/min: Uncomplicated UTI: 1.5 g IV every 8 hours.
Complicated UTI: 1.5 g IV every 8 hours.
Severe systemic infection: 2 g IV every 8 hours.
Life-threatening infection: 2 g IV every 6 hours.
CrCl 10 to 30 mL/min: Uncomplicated UTI: 1.5 g IV every 8 hours.
Complicated UTI: 1.5 g IV every 6 hours.
Severe systemic infection: 3 g IV every 8 hours.
Life-threatening infection: 3 g IV every 6 hours.
Liver Dose Adjustments
No adjustment required
For patients with renal failure and hepatic insufficiency, measurement of serum levels of mezlocillin will provide additional guidance for adjusting dosage.
Use caution when administering to patients with biliary obstruction. Doses should be reduced in patients with renal dysfunction.
For patients with serious systemic infection undergoing hemodialysis, 3 to 4 g may be given after each dialysis and then every 12 hours. Patients undergoing peritoneal dialysis may receive 3 g every 12 hours.
Mezlocillin may be given by the IV or intramuscular route of administration. For serious infections, the IV route should be used. Intramuscular doses should not exceed 2 g/injection.
Antibiotic therapy for Group A Beta-hemolytic streptococcal infections should be maintained for at least 10 days to reduce the risk of rheumatic fever or glomerulonephritis.
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