Skip to Content

Maxalt-MLT Side Effects

Generic Name: rizatriptan

Note: This page contains information about the side effects of rizatriptan. Some of the dosage forms included on this document may not apply to the brand name Maxalt-MLT.

In Summary

More frequent side effects include: dizziness, weakness, drowsiness, fatigue, paresthesia, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to rizatriptan: oral tablet, oral tablet disintegrating

In addition to its needed effects, some unwanted effects may be caused by rizatriptan (the active ingredient contained in Maxalt-MLT). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking rizatriptan:

More common:
  • Chest pain
  • heaviness, tightness, or pressure in the chest and/or neck
  • pounding heartbeat
  • sensation of burning, warmth, heat, numbness, tightness, or tingling
  • shortness of breath
Less common:
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • increased heartbeat
  • irregular heartbeat
  • pain, tightness, or pressure in the neck, jaw, or throat
  • slow heartbeat

Minor Side Effects

Some of the side effects that can occur with rizatriptan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Dizziness
  • dry mouth
  • hot flashes
  • lack or loss of strength
  • nausea or vomiting
  • sleepiness or unusual drowsiness
  • unusual tiredness or weakness
Less common:
  • Agitation
  • anxiety
  • blurred vision
  • chills
  • confusion
  • constipation
  • depression
  • diarrhea
  • difficulty with swallowing
  • dry eyes
  • eye irritation
  • feeling of constant movement of self or surroundings
  • gas
  • headache
  • heartburn
  • heat sensitivity
  • inability to sleep
  • increased sweating
  • increased thirst
  • irritability
  • itching of the skin
  • muscle or joint stiffness, tightness, or rigidity
  • muscle pain or spasms
  • ringing or buzzing in the ears
  • sudden, large increase in the frequency or quantity of urine
  • trembling of the hands or feet
  • unusual feeling of well-being
  • warm or cold sensations

For Healthcare Professionals

Applies to rizatriptan: oral tablet, oral tablet disintegrating

General

The most commonly reported adverse reactions include pain/pressure sensation, asthenia/fatigue, somnolence, and dizziness.[Ref]

Cardiovascular

Common (1% to 10%): Palpitation, chest pain (tightness/pressure and/or heaviness), flushing
Uncommon (0.1% to 1%): Tachycardia, cold extremities, bradycardia, arrhythmia, ECG abnormalities
Rare (less than 0.1%): Syncope, edema/swelling
Frequency not reported: Acute myocardial infarction, blood pressure elevations
Postmarketing reports: Peripheral vascular ischemia[Ref]

Rarely, patients with and without a history of hypertension have experienced significant blood pressure elevations including hypertensive crisis with the use of triptans including this drug. Increases of approximately 2 to 3 mmHg have been observed in healthy subjects receiving 10 mg of this drug every 2 hours for 3 doses.[Ref]

Gastrointestinal

Common (1% to 10%): Dry mouth, nausea
Uncommon (0.1% to 1%): Vomiting, diarrhea, dyspepsia, tongue edema, abdominal distention, thirst
Frequency not reported: Ischemic colitis[Ref]

Nervous system

Very common (10% or more): Dizziness (14%)
Common (1% to 10%): Paresthesia, headache, somnolence, tremor
Uncommon (0.1% to 1%): Vertigo, confusion/disorientation, gait abnormality, memory impairment, abnormal coordination
Frequency not reported: Serotonin syndrome
Postmarketing reports: Seizure, dysgeusia[Ref]

Hypersensitivity

Postmarketing reports: Allergic conditions including anaphylaxis/anaphylactoid reaction, angioedema, wheezing, and toxic epidermal necrolysis[Ref]

Other

Common (1% to 10%): Asthenia/fatigue, neck/throat/jaw pain/tightness/pressure, warm sensation
Uncommon (0.1% to 1%): Tinnitus
Rare (less than 0.1%): Hypoacusis[Ref]

Dermatologic

Uncommon (0.1% to 1%): Facial edema, sweating, pruritus, rash, urticaria
Rare (less than 0.1%): Erythema
Frequency not reported: Toxic epidermal necrolysis[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Muscle weakness, stiffness, myalgia, muscle cramp/spasm
Postmarketing reports: Facial pain[Ref]

Ocular

Uncommon (0.1% to 1%): Blurred vision
Rare (less than 0.1%): Eye swelling[Ref]

Psychiatric

Common (1% to 10%): Euphoria, insomnia
Uncommon (0.1% to 1%): Agitation, hallucination[Ref]

Respiratory

Common (1% to 10%): Dyspnea
Uncommon (0.1% to 1%): Pharyngeal edema[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Maxalt (rizatriptan)." Merck & Co, Inc, West Point, PA.

Not all side effects for Maxalt-MLT may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide