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Maxalt-MLT Side Effects

Generic name: rizatriptan

Medically reviewed by Last updated on Dec 27, 2023.

Note: This document contains side effect information about rizatriptan. Some dosage forms listed on this page may not apply to the brand name Maxalt-MLT.

Applies to rizatriptan: oral tablet, oral tablet disintegrating.

Serious side effects of Maxalt-MLT

Along with its needed effects, rizatriptan (the active ingredient contained in Maxalt-MLT) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rizatriptan:

More common

Less common

Incidence not known

Other side effects of Maxalt-MLT

Some side effects of rizatriptan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Incidence not known

For Healthcare Professionals

Applies to rizatriptan: oral film, oral tablet, oral tablet disintegrating.


The most commonly reported adverse reactions include pain/pressure sensation, asthenia/fatigue, somnolence, and dizziness.[Ref]


Rarely, patients with and without a history of hypertension have experienced significant blood pressure elevations including hypertensive crisis with the use of triptans including this drug. Increases of approximately 2 to 3 mmHg have been observed in healthy subjects receiving 10 mg of this drug every 2 hours for 3 doses.[Ref]

Common (1% to 10%): Palpitation, chest pain (tightness/pressure and/or heaviness), flushing

Uncommon (0.1% to 1%): Tachycardia, cold extremities, bradycardia, arrhythmia, ECG abnormalities

Rare (less than 0.1%): Syncope, edema/swelling

Frequency not reported: Acute myocardial infarction, blood pressure elevations

Postmarketing reports: Peripheral vascular ischemia[Ref]


Common (1% to 10%): Dry mouth, nausea

Uncommon (0.1% to 1%): Vomiting, diarrhea, dyspepsia, tongue edema, abdominal distention, thirst

Frequency not reported: Ischemic colitis[Ref]

Nervous system

Very common (10% or more): Dizziness (14%)

Common (1% to 10%): Paresthesia, headache, somnolence, tremor

Uncommon (0.1% to 1%): Vertigo, confusion/disorientation, gait abnormality, memory impairment, abnormal coordination

Frequency not reported: Serotonin syndrome

Postmarketing reports: Seizure, dysgeusia[Ref]


Postmarketing reports: Allergic conditions including anaphylaxis/anaphylactoid reaction, angioedema, wheezing, and toxic epidermal necrolysis[Ref]


Common (1% to 10%): Asthenia/fatigue, neck/throat/jaw pain/tightness/pressure, warm sensation

Uncommon (0.1% to 1%): Tinnitus

Rare (less than 0.1%): Hypoacusis[Ref]


Uncommon (0.1% to 1%): Facial edema, sweating, pruritus, rash, urticaria

Rare (less than 0.1%): Erythema

Frequency not reported: Toxic epidermal necrolysis[Ref]


Uncommon (0.1% to 1%): Muscle weakness, stiffness, myalgia, muscle cramp/spasm

Postmarketing reports: Facial pain[Ref]


Uncommon (0.1% to 1%): Blurred vision

Rare (less than 0.1%): Eye swelling[Ref]


Common (1% to 10%): Euphoria, insomnia

Uncommon (0.1% to 1%): Agitation, hallucination[Ref]


Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Pharyngeal edema[Ref]

Frequently asked questions


1. Product Information. Maxalt (rizatriptan). Merck & Co., Inc. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.