Lutetium Lu 177 Dotatate Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 16, 2024.

Applies to lutetium lu 177 dotatate: intravenous solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Receiving this medicine while you are pregnant can harm your unborn baby. It may also cause birth defects if the father is receiving it when his sexual partner becomes pregnant. Female patients should use effective birth control during treatment with this medicine and for at least 7 months after the last dose. Male patients who have female partners should use effective birth control during treatment with this medicine and for at least 4 months after the last dose. If you think you have become pregnant while using this medicine, tell your doctor right away.

If you are a woman who can get pregnant, you must have a negative pregnancy test before you will be allowed to receive this medicine. If you miss a period while you are receiving this medicine, tell your doctor right away.

If you plan to have children, talk with your doctor before using this medicine. Some men and women using this medicine have become infertile (unable to have children).

This medicine may increase your risk of having cancer (eg, secondary myelodysplastic syndrome, leukemia). Talk to your doctor if you have concerns.

You will be exposed to radiation when you receive this medicine and can be detected in your urine for up to 30 days. Talk with your doctor about the ways to lessen the exposure of radiation in your household and if you have concerns.

Lutetium Lu 177 dotatate may lower the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem. Drink plenty of fluids and urinate as often as possible during and after receiving this medicine.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. This is more likely if you have liver metastasis (cancer that has spread).

Serious side effects

Along with its needed effects, lutetium lu 177 dotatate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lutetium lu 177 dotatate:

Other side effects

Some side effects of lutetium lu 177 dotatate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to lutetium lu 177 dotatate: intravenous solution.

Hematologic adverse events

• Common (1% to 10%): Lymphopenia, leukopenia, neutropenia, thrombocytopenia, anemia^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain, pain in extremity, myalgia, neck pain^[Ref]

Metabolic

• Common (1% to 10%): Decreased appetite, hyperglycemia, hypocalcemia, hypokalemia, hyperkalemia, hypernatremia, hypoglycemia^[Ref]

Psychiatric

• Common (1% to 10%): Anxiety^[Ref]

Hepatic

• Common (1% to 10%): GGT increased, alkaline phosphatase increased, AST increased, ALT increased, blood bilirubin increased^[Ref]

Respiratory

• Common (1% to 10%): Cough^[Ref]

Other

• Common (1% to 10%): Fatigue, peripheral edema, pyrexia^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness, dysgeusia^[Ref]

Renal

• Common (1% to 10%): Renal failure (glomerular filtration rate decreased, acute kidney injury, acute prerenal failure, azotemia, renal disorder, renal failure, renal impairment); hyperuricemia; creatinine increased^[Ref]

Cardiovascular

• Common (1% to 10%): Atrial fibrillation, flushing, hypertension^[Ref]

Dermatologic

• Common (1% to 10%): Alopecia

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting abdominal pain, diarrhea, constipation^[Ref]

Genitourinary

• Common (1% to 10%): Radiation related urinary tract toxicity (dysuria, micturition urgency, nocturia, pollakiuria, renal colic, renal pain, urinary tract pain and urinary incontinence)

See also:

Further information

Lutetium lu 177 dotatate side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer