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Loteprednol / tobramycin ophthalmic Side Effects

Medically reviewed by Last updated on Nov 29, 2023.

Applies to loteprednol/tobramycin ophthalmic: ophthalmic suspension.

Serious side effects

Along with its needed effects, loteprednol/tobramycin ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking loteprednol / tobramycin ophthalmic:

More common

Less common

Incidence not known

Other side effects

Some side effects of loteprednol / tobramycin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to loteprednol / tobramycin ophthalmic: ophthalmic suspension.


Very common (10% or more): Injection (20%), superficial punctuate keratitis (15%), intraocular pressure increased (10%)

Frequency not reported: Vision disorder, discharge, itching, lacrimation disorder, photophobia, corneal deposit, ocular discomfort, eyelid disorder, unspecified eye disorder

Loteprednol etabonate:

Frequency not reported: Intraocular pressure increased, visual acuity defect, field defect, posterior subcapsular cataract formation, delayed wound healing, secondary ocular infection


Frequency not reported: Lid itching, conjunctival erythema, lid swelling[Ref]

Nervous system

Very common (10% or more): Headache (14%)[Ref]



Frequency not reported: Hypersensitivity[Ref]


The most frequently reported side effects were injections and superficial punctate keratitis, increased intraocular pressure, and burning and stinging upon instillation.[Ref]


Common (1% to 10%): Burning, stinging


Frequency not reported: Localized ocular toxicity[Ref]


1. (2005) "Product Information. Zylet (loteprednol-tobramycin ophthalmic)." Bausch and Lomb Americas, Inc.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.