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Lomanate Side Effects

Generic Name: atropine / diphenoxylate

Note: This page contains information about the side effects of atropine / diphenoxylate. Some of the dosage forms included on this document may not apply to the brand name Lomanate.

For the Consumer

Applies to atropine / diphenoxylate: oral solution, oral tablet

In addition to its needed effects, some unwanted effects may be caused by atropine / diphenoxylate. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking atropine / diphenoxylate:

  • Bloating
  • constipation
  • loss of appetite
  • stomach pain (severe) with nausea and vomiting

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking atropine / diphenoxylate:

  • Blurred vision (continuing) or changes in near vision
  • drowsiness (severe)
  • dryness of mouth, nose, and throat (severe)
  • fast heartbeat
  • shortness of breath or troubled breathing (severe)
  • unusual excitement, nervousness, restlessness, or irritability
  • unusual warmth, dryness, and flushing of the skin

Minor Side Effects

Some of the side effects that can occur with atropine / diphenoxylate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common or rare:
  • Blurred vision
  • confusion
  • difficult urination
  • dizziness or light-headedness
  • drowsiness
  • dryness of skin and mouth
  • fever
  • headache
  • increased body temperature
  • mental depression
  • numbness of hands or feet
  • skin rash or itching
  • swelling of the gums

Side Effects: Post Treatment

After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

Rare
  • Increased sweating
  • muscle cramps
  • nausea or vomiting
  • shivering or trembling
  • stomach cramps

For Healthcare Professionals

Applies to atropine / diphenoxylate: oral liquid, oral tablet

Nervous system

Frequency not reported: Numbness of extremities, sedation/drowsiness, dizziness, headache, somnolence[Ref]

Gastrointestinal

Frequency not reported: Swelling of the gums, toxic megacolon, paralytic ileus, pancreatitis, vomiting, nausea, abdominal discomfort, constipation[Ref]

Cardiovascular

Frequency not reported: Tachycardia, cardiac irregularities (e.g. arrhythmias, bradycardia, palpitations)[Ref]

Ocular

Frequency not reported: Increased intraocular pressure, dilation of pupils with loss of accommodation, photophobia, angle closure glaucoma[Ref]

Genitourinary

Frequency not reported: Urinary retention, difficulty in micturition[Ref]

Psychiatric

Frequency not reported: Euphoria, depression, confusion, restlessness, hallucinations[Ref]

Dermatologic

Frequency not reported: Urticaria, pruritus, flushing[Ref]

Hypersensitivity

Frequency not reported: Anaphylaxis, angioneurotic edema[Ref]

Metabolic

Frequency not reported: Anorexia[Ref]

Respiratory

Frequency not reported: Respiratory depression in children[Ref]

Other

Frequency not reported: Malaise/lethargy, hyperthermia, dryness of the skin and mucous membranes[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Lomotil (diphenoxylate-atropine)." Searle, Skokie, IL.

Not all side effects for Lomanate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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