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Lidex Side Effects

Generic name: fluocinonide topical

Medically reviewed by Last updated on Feb 1, 2024.

Note: This document contains side effect information about fluocinonide topical. Some dosage forms listed on this page may not apply to the brand name Lidex.

Applies to fluocinonide topical: topical application cream, topical application emollient cream, topical application gel/jelly, topical application ointment, topical application solution.

Serious side effects of Lidex

Along with its needed effects, fluocinonide topical (the active ingredient contained in Lidex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluocinonide topical:

Incidence not known

Other side effects of Lidex

Some side effects of fluocinonide topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

For Healthcare Professionals

Applies to fluocinonide topical: compounding powder, topical cream, topical gel, topical kit, topical ointment, topical solution.


The most commonly reported side effects were burning, itching, irritation, and dryness.


Postmarketing reports: Hypersensitivity[Ref]


Frequency not reported: Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome[Ref]


Common (1% to 10%): Application site burning

Frequency not reported: Itching, dryness

Postmarketing reports: Discoloration, erythema, pruritus, swelling, pain, condition aggravated[Ref]

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Intracranial hypertension (including bulging fontanelles, bilateral papilledema)

Postmarketing reports: Dizziness[Ref]


Frequency not reported: Irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria

Postmarketing reports: Acne, dry skin, rash, skin exfoliation, skin tightness[Ref]


Frequency not reported: Hyperglycemia, glucosuria[Ref]


Common (1% to 10%) Nasopharyngitis, nasal congestion[Ref]

Frequently asked questions


1. Product Information. Lidex (fluocinonide topical). Syntex Laboratories Inc. 2022.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.