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Isoflurane Side Effects

Medically reviewed by Last updated on Aug 26, 2023.

Applies to isoflurane: inhalation liquid, inhalation solution.

Serious side effects of Isoflurane

Along with its needed effects, isoflurane may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking isoflurane:

More common

Less common


Incidence not known

Other side effects of Isoflurane

Some side effects of isoflurane may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common


Incidence not known

For Healthcare Professionals

Applies to isoflurane: inhalation liquid.


Frequency not reported: Hepatocellular injury, blood bilirubin increased, hepatic enzymes increased

Postmarketing reports: Hepatic necrosis, hepatic failure[Ref]


Frequency not reported: Nausea, vomiting, ileus[Ref]


Very common (10% or more): Coughing

Common (1% to 10%): Laryngospasm

Uncommon (0.1% to 1%): Secretions

Rare (less than 0.1%): Bronchospasm, dyspnea, wheezing, chest discomfort

Frequency not reported: Respiratory depression[Ref]


Frequency not reported: Hyperkalemia, blood glucose increased[Ref]


Frequency not reported: Carboxyhemoglobinemia, hemorrhage, white blood cell count increased[Ref]


Frequency not reported: Anaphylactic reaction, hypersensitivity[Ref]


Frequency not reported: Shivering, chills, myoglobinuria, rhabdomyolysis[Ref]


Frequency not reported: Agitation, delirium, altered mood, mental impairment[Ref]


Frequency not reported: Malignant hyperthermia, fluoride increased, blood cholesterol decreased, blood alkaline phosphatase decreased[Ref]

Nervous system

Frequency not reported: Convulsion[Ref]


Frequency not reported: Blood creatinine increased, blood urea decreased[Ref]


Uncommon (0.1% to 1%): Postoperative hypotension

Rare (less than 0.1%): Postoperative hypertension

Frequency not reported: Hypotension, arrhythmia, bradycardia, cardiac arrest, QT prolonged, tachycardia, torsade de pointes

Postmarketing reports: Cardiac arrest[Ref]


Frequency not reported: Swelling face, contact dermatitis, rash[Ref]


1. (2009) "Product Information. Forane (isoflurane)." Baxter Pharmaceutical Products, Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.